Dileep Francis - Böcker

This book comprehensively reviews the diverse potential of microbial enzymes with therapeutic applications, covering their production, purification, and utilization. It examines their roles in combating various diseases, including inflammation, bacterial infections, cardiovascular conditions, and thrombotic disorders. The book highlights their pharmaceutical applications in drug formulation and bioactive compound production, with the aim of enhancing drug bioavailability, stability, and efficacy. Furthermore, the book explores the potential of microbial fibrinolytic enzymes to revolutionize treatments for thrombotic disorders. It also outlines the applications of microbial enzymes in targeting cancer cells, emphasizing their pivotal role in innovative treatment modalities. Additionally, the book presents the therapeutic applications of microbial lipases, from their use in lipid-lowering medications to the creation of lipase-based pharmaceuticals.The chapters discuss the potential of microbial uricases in managing uric-acid-related disorders and the contribution of microbial enzymes in enhancing digestion and alleviating digestive disorders. Finally, the book delves into the vital role of regulatory authorities and intellectual property rights (IPR) in the commercialization of therapeutic microbial enzymes. As such, this book serves as a valuable resource for researchers, professionals, and students of microbiology, biotechnology, and pharmaceutical sciences.Key Features:Reviews the therapeutic potential of microbial enzymes and their production and purificationExamines the roles of microbial enzymes in combating a wide range of diseases, including inflammation, bacterial infections, cardiovascular conditions, and thrombotic disordersHighlights the pharmaceutical applications of microbial enzymes, focusing on drug formulation and the production of bioactive compounds to enhance drug bioavailability, stability, and efficacyExplores the therapeutic applications of microbial lipases, from lipid-lowering medications to the creation of lipase-based pharmaceuticalsPresents the vital role of regulatory authorities and intellectual property rights (IPR) in the commercialization of therapeutic microbial enzymes

This book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery.Focusing on the drug targets blocked/altered by natural/nature-inspired molecules, it covers how potential drug leads are screened and identified using appropriate assay systems, and the current status of drugs identified using such approaches. State-of-the-art approaches in target identification, assay development, and lead identification have also been discussed in detail. Other topics included are targets and leads in inflammation, cancer, reproductive medicine, cardiovascular and neuromuscular ailments, and infectious diseases as well as the challenges in translating drug leads into clinically viable drugs.This volume serves as a handbook for researchers in phytochemistry and drug discovery, and as a reference for researchers and students of applied biology.