Domenico Piccolo – författare

Adipose tissue (also known as fat tissue) is a human tissue with a high concentration of adult mesenchymal stem cells (ADSCs), the proven regenerative capacities of which have now applications in various medical fields as reconstructive surgery, dermatology, scar therapy, orthopedics, vascular surgery, cardiology, gynecology, otolaryngology, proctology, as well as in antiaging therapies in cosmetic surgery or aesthetic medicine. Regenerative therapy has proven very promising in face rejuvenation, where skin atrophy and volume loss, the main factors beyond facial aging, cause facial rhytids, laxity, skeletonization, and pseudo-descent of the midface. This handy guide offers a new standardized, guided procedure, the Superficial Enhanced Fluid Fat Injection (or S.E.F.F.I.), that will enable professionals dealing in an outpatient setting to perform safe, effective tissue rejuvenation, increasing the patient’s compliance, guaranteeing effectiveness, reducing risks and costs. Harvesting subcutaneous adipose tissue is a critical process without a specific training, exposing the patient to possible complications related to incorrect harvesting maneuvers. The guided SEFFI procedure allows to perform harvesting at a safe plane and 1.5mm depth, explains how to restore volume and regenerate the skin injecting viable adipocytes, by adhering to a rigorous clinical protocol, following steps in images and videos. In particular, chapters deal with making tissue harvesting less traumatic, collecting cells in the most superficial plane to gain a richer tissue in terms of Stromal Vascular Fraction Cells (SVFCs) and mesenchymal stem cells (ADSCs), and harvesting the cell clusters containing adipocytes, SVFCs and ADSCs of reduced size, avoiding fragmentation devices and unnecessary manipulation. Associated treatments (controlled deep peeling, trichloroacetic acid) for combination with the SEFFI procedure, and it application in reconstructive hair transplantation and remodelingafter injury. This guide to safe and effective rejuvenation treatments through the SEFFI protocol will enable dermatologists and aesthetic medicine practitioners to offer safe, simple, effective, and standardized regenerative therapy to their patients.

This quick guide demonstrates the value of dermoscopy before, during, and after the treatment of a wide variety of vascular and other skin lesions with laser and/or intense pulsed light (IPL). The coverage includes the treatment of benign pigmented pathologies, melanocytic nevi, seborrheic dermatoses, solar lentigines, telangiectasias, flat angiomas, port-wine scars, other vascular pathologies, keloids and hypertrophic scars, acne and post-traumatic scars, and tattoos. Practically oriented information is also supplied on the dermoscopic technique, the principles of use of lasers and IPL in dermatology, laser–tissue interactions, and types of laser. This will help the reader to comprehend the importance of lasers and IPL in clinical practice and provide excellent preparation for the use of dermoscopy to visualize the targets to be hit with laser or IPL. The inclusion of more than 100 color photos stored before, during, and after dermoscopy-aided laser or IPL treatment documents the results that can be achieved even in pathologies that were very difficult to cure until several years ago.

The growing capabilities in generating and collecting data has risen an urgent need of new techniques and tools in order to analyze, classify and summarize statistical information, as well as to discover and characterize trends, and to automatically bag anomalies. This volume provides the latest advances in data analysis methods for multidimensional data which can present a complex structure: The book offers a selection of papers presented at the first Joint Meeting of the Société Francophone de Classification and the Classification and Data Analysis Group of the Italian Statistical Society. Special attention is paid to new methodological contributions from both the theoretical and the applicative point of views, in the fields of Clustering, Classification, Time Series Analysis, Multidimensional Data Analysis, Knowledge Discovery from Large Datasets, Spatial Statistics.

The book presents statistical methods and models that can usefully support the ev- uation of educational services and quality of products. The contributions collected in this book summarize the work of several researchers from the universities of Bologna, Firenze, Napoli and Padova. The contributions are written with a cons- tent notation and a uni?ed view, and concern methodological advances developed mostly with reference to speci?c problems of evaluation using real data sets. The evaluation of educational services, as well as the analysis of judgements and preferences, poses severe methodological challenges because of the presence of one or more of the following aspects: the observational (non experimental) nature of the context, which is associated with the well-known problems of selection bias and presence of nuisance factors; the hierarchical structure of the data, that entails c- related observations and consideration of effects at different levels of the hierarchy and their interactions (multilevel analysis); the multivariate and qualitative nature of the dependent variable, that requires the use of ad hoc statistical methodologies; the presence of non observable factors, e. g. the satisfaction, calling for the use of latent variables models; the simultaneous presence of components of pleasure and components of uncertainty in the explication of the judgments, that asks for the speci?cation and estimation of mixture models. The ?rst part of the book deals with latent variable models.