Ebru Emekli-Alturfan – författare

Advancing our understanding of neurodegenerative diseases demands innovative tools and approaches. Zebrafish Models in Neurodegenerative Disorders offers a comprehensive examination of zebrafish as a translational model for studying the molecular and cellular mechanisms of diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Beginning with the first section informing about the basic molecular mechanisms of neurodegenerative disorders, biomarkers, and therapeutic approaches, the book continues with the detailed exploration of zebrafish physiology, genetics, and behavioural phenotypes as they pertain to neurodegenerative pathologies; insight into cutting-edge technologies, including CRISPR/Cas9 genome editing; and in-depth analysis of zebrafish models, highlighting their strengths in modelling disease progression and therapeutic testing.

Zebrafish are becoming a fascinating new animal model for a variety of neurodegenerative diseases such as Parkinson’s disease, Alzheimer‘s disease, multiple sclerosis and other demyelinating diseases. Zebrafish produce a lot of embryos, grow quickly, are optically clear, and are receptive to genetic modification. They are therefore superior to current in vivo models in that they may be used to study neurological illnesses and create high-throughput drug screens. This book presents information on the use of zebrafish as a model organism in the modeling of neurodegenerative diseases with contributions from experts in the field. The general characteristics of zebrafish as a model organism are reviewed and neurogenesis and its regulation in zebrafish embryos is explained. Information about the use of zebrafish in NGS diseases such as Parkinson''s, Alzheimer''s and multiple sclerosis is presented. It is aimed to explain both toxin-induced and genetic models of separately.