Animal cell technology is a discipline of growing importance, which aims not merely at understanding structure, function and behaviour of differentiated animal cells, but especially at the development of their abilities useful for clinical application. Topics of interest in this regard include: viral vaccines, pharmaceutical proteins and novel applications such as gene therapy and organ culture. Undoubtedly, these Proceedings of the joint Meeting of the European Society for Animal Cell Technology and the Japanese Association for Animal Cell Technology (Veldhoven, The Netherlands, September 1994) review the most recent status of the field, and will be most valuable to anyone actively involved in the culture of animal cells and its applications. The contributions to this volume were strictly selected on the basis of quality and novelty of contents. Kluwer is honoured to be able to add this work to its strongly developing publication programme in cell and tissue culture, which now has its connections to all major Societies in this field worldwide. Audience: Cell biologists, biochemists, molecular biologists, immunologists, virologists and all other disciplines related to animal cell technology, working in an academic environment, as well as in (biotechnology or pharmaceutical) industry.

Animal cell technology is a discipline of growing importance, which aims not merely at understanding structure, function and behaviour of differentiated animal cells, but especially at the development of their abilities useful for clinical application. Topics of interest in this regard include: viral vaccines, pharmaceutical proteins and novel applications such as gene therapy and organ culture. Undoubtedly, these Proceedings of the joint Meeting of the European Society for Animal Cell Technology and the Japanese Association for Animal Cell Technology (Veldhoven, The Netherlands, September 1994) review the most recent status of the field, and will be most valuable to anyone actively involved in the culture of animal cells and its applications. The contributions to this volume were strictly selected on the basis of quality and novelty of contents. Kluwer is honoured to be able to add this work to its strongly developing publication programme in cell and tissue culture, which now has its connections to all major Societies in this field worldwide. Audience: Cell biologists, biochemists, molecular biologists, immunologists, virologists and all other disciplines related to animal cell technology, working in an academic environment, as well as in (biotechnology or pharmaceutical) industry.

The 5th Pathogenic Neisseriae Conference was held in Noordwijkerhout, The Netherlands, on 15-18 September 1986. It followed San Francisco - USA (1978), Hemavan - Sweden (1980), Montreal - Canada (1982), Asilomar - USA (1984). These conferences will continue to be held in the foreseeing future. The reason for this is because studying pathogenic Neisseriae enables research workers to look at many aspects of bacterial infectious diseases. These aspects include: - Epidemiology and vaccination (section 1) - Genetic aspects of antigenic diversity (section 2) - Outer membrane proteins and IgA-protease (section 3) - Lipopolysaccharides, H8 antigen and peptidoglycan (section ~) - The application of all this knowledge to study pathogenesis (section 5) N. gonorrhoeae has become an important model organism to study mucosal bacterial infectious diseases. Basic knowledge about the bacterial surface, gene- tics and physiology is linked to pathogenic mechanisms such as adhesion to and invasion of epithelial cells, interaction with complement and phagocytic cells and mucosal immune mechanisms. This will continue to be an important research field in the near future. N. meningitidis has become an important model organism to study the epide- miology of potentially epidemic bacterial diseases and against which new type of vaccines are being developed such as outer membrane protein vaccines.The above mentioned topics are covered by papers presented at The 5th Path- ogenic Neisseriae Conference, 1986. I would like to thank Marijke van de Nadort without whom it would have been much harder or even impossible to organize such a meeting.

Animal cell technology is a discipline of growing importance, which aims not merely at understanding structure, function and behaviour of differentiated animal cells, but especially at the development of their abilities useful for clinical application. Topics of interest in this regard include: viral vaccines, pharmaceutical proteins and novel applications such as gene therapy and organ culture. Undoubtedly, these Proceedings of the joint Meeting of the European Society for Animal Cell Technology and the Japanese Association for Animal Cell Technology (Veldhoven, The Netherlands, September 1994) review the most recent status of the field, and will be most valuable to anyone actively involved in the culture of animal cells and its applications. The contributions to this volume were strictly selected on the basis of quality and novelty of contents. Kluwer is honoured to be able to add this work to its strongly developing publication programme in cell and tissue culture, which now has its connections to all major Societies in this field worldwide. Audience: Cell biologists, biochemists, molecular biologists, immunologists, virologists and all other disciplines related to animal cell technology, working in an academic environment, as well as in (biotechnology or pharmaceutical) industry.

Animal cell technology is a discipline of growing importance, which aims not merely at understanding structure, function and behaviour of differentiated animal cells, but especially at the development of their abilities useful for clinical application. Topics of interest in this regard include: viral vaccines, pharmaceutical proteins and novel applications such as gene therapy and organ culture. Undoubtedly, these Proceedings of the joint Meeting of the European Society for Animal Cell Technology and the Japanese Association for Animal Cell Technology (Veldhoven, The Netherlands, September 1994) review the most recent status of the field, and will be most valuable to anyone actively involved in the culture of animal cells and its applications. The contributions to this volume were strictly selected on the basis of quality and novelty of contents. Kluwer is honoured to be able to add this work to its strongly developing publication programme in cell and tissue culture, which now has its connections to all major Societies in this field worldwide. Audience: Cell biologists, biochemists, molecular biologists, immunologists, virologists and all other disciplines related to animal cell technology, working in an academic environment, as well as in (biotechnology or pharmaceutical) industry.

The 5th Pathogenic Neisseriae Conference was held in Noordwijkerhout, The Netherlands, on 15-18 September 1986. It followed San Francisco - USA (1978), Hemavan - Sweden (1980), Montreal - Canada (1982), Asilomar - USA (1984). These conferences will continue to be held in the foreseeing future. The reason for this is because studying pathogenic Neisseriae enables research workers to look at many aspects of bacterial infectious diseases. These aspects include: - Epidemiology and vaccination (section 1) - Genetic aspects of antigenic diversity (section 2) - Outer membrane proteins and IgA-protease (section 3) - Lipopolysaccharides, H8 antigen and peptidoglycan (section ~) - The application of all this knowledge to study pathogenesis (section 5) N. gonorrhoeae has become an important model organism to study mucosal bacterial infectious diseases. Basic knowledge about the bacterial surface, gene- tics and physiology is linked to pathogenic mechanisms such as adhesion to and invasion of epithelial cells, interaction with complement and phagocytic cells and mucosal immune mechanisms. This will continue to be an important research field in the near future. N. meningitidis has become an important model organism to study the epide- miology of potentially epidemic bacterial diseases and against which new type of vaccines are being developed such as outer membrane protein vaccines.The above mentioned topics are covered by papers presented at The 5th Path- ogenic Neisseriae Conference, 1986. I would like to thank Marijke van de Nadort without whom it would have been much harder or even impossible to organize such a meeting.