Edgar Pick – författare

Lymphokines: A Forum for Immunoregulatory Cell Products deals with immunoregulatory cell products that produce lymphokines. Topics covered include the purification and characterization of transfer factor; activation of cytotoxicity and/or suppressor activity in murine macrophages by lymphokines, lipopolysaccharide, and polyinosinic-polycytidylic acid; and the role of clotting processes in the action of lymphokines on macrophages. A comparison of the immune-modulating effects of interferon and interferon inducers is also presented. Comprised of 13 chapters, this volume begins with a discussion on transfer factor and its ability to react specifically with antigens. The clinical uses of transfer factor are considered with special emphasis on its value as a prophylactic agent. The reader is then introduced to the subject of T cell regulation of the immunoglobulin E (IgE) response via potentiating and suppressor lymphokines, together with the possible clinical application of IgE suppressive factors in the treatment of atopic diseases. Subsequent chapters examine the evidence in favor of the existence of T cell-derived polyclonal B cell activator (PBA) playing a role in both normal antibody responses and autoimmune diseases; the role of suppressor T cells and the associated lymphokines in contact sensitivity in mice; and lymphokine action on macrophages. The book also analyzes the genetics of the response of human and mouse cells to interferons. This monograph will be helpful to practitioners and researchers in the fields of microbiology and immunology.

Lymphokines: A Forum for Immunoregulatory Cell Products, Volume 14, reviews the state of knowledge on lymphokines. The book opens with an integrative view of the role of lymphokines in the generation of fever. It stresses that pirogenicity is the attribute of more than one lymphokine: interleukin 1 (IL-1), interferon α, and tumor necrosis factor (TNF) all possess this quality. This is followed by separate chapters on the chemistry of IL-1 molecules and cloning of the gene for human monocyte IL-1; the production of lymphokine by cells of the central nervous system; the acute phase plasma protein response studied at the level of gene structure and expression; and the involvement of calcium and calcium-linked enzymes in T cell proliferation. Subsequent chapters deal with the involvement of pteridines in T cell activation; the discovery of cachectin and the establishment of its identity with TNF; the effect of IFN-γ and several cytotoxic cytokines on the proliferation, differentiation, and function of normal and leukemic myeloid cells; and the cytotoxic lymphokines produced by effector T cells. The final chapter discusses the ways in which chemically defined changes in cell membranes affect cell division.

Biology of the Lymphokines discusses the scope and diversity of lymphokine research. This book focuses on the studies on lymphokines, such as those involving cellular source, chemical nature, purification strategies, and bioassay limitations. The mechanism of lymphokine action, lymphokines in vivo, and value of lymphokine quantitations are also covered. This text describes the repertoire of lymphokines produced by various lymphoblastoid cell lines and its significance for coping with the problem of large scale lymphokine production. The anti-viral and general immunoregulatory properties of interferons and rationale developed for integrating interferons with the family of lymphokines are likewise deliberated. This publication is a good source for students and researchers conducting work on lymphokines.

This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field.The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research.Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.

This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field.The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research.Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.

This book provides an up‑to‑date overview of the multiple roles of NADPH oxidases (Noxes) in human health and disease. Building on the earlier volume NADPH Oxidases Revisited: From Function to Structure, it shifts the focus toward the involvement of Nox enzymes in pathogenic mechanisms and their emerging relevance for therapeutic strategies.The book highlights the biochemistry, structure, and function of Noxes, with emphasis on structural similarities, regulation of Nox expression, the molecular basis of conversion from resting to activated state, de novo cytochrome design, and their relation to voltage gated proton channels. The book contains a detailed description of Nox products serving as effectors of the microbicidal action of phagocytes (superoxide, peroxynitrite, heme peroxidases) and of the role of NADPH oxidases in inducing ferroptosis. It also places emphasis on the role of Nox-derived reactive oxygen species (ROS), in signaling pathways, with hydrogen peroxide acting as a second messenger. Facing the Nox-derived cytotoxic effectors, the book offers several chapters focused on molecules responsible for antioxidative defense, namely, superoxide dismutases, thioredoxin reductases, and peroxiredoxins. The whole cell aspects of Nox action are addressed in chapters focused on the phagosome and on extracellular traps. A major part of the book deals, as expected from its title, with the contribution of Nox enzymes to the pathogenesis of a broad range of diseases, comprising Nox-related immunodeficiencies, liver fibrosis and cancer, pulmonary fibrosis, inflammatory bowel disease, neurodegenerative diseases, epilepsy, cardiovascular disease, and infertility — and discusses the therapeutic potential of targeting Nox‑mediated pathogenic pathways.Two essays, a recollection by and a homage to scientists who were active from the infancy of Nox research, serve as an introduction to the book, providing historical context and personal perspectives on the development of Nox research.Advances in NADPH Oxidases Research: From Molecules to Diseases brings together cellular, molecular, structural, and translational insights, offering a concise yet comprehensive resource for researchers and clinicians interested in the biology and medical relevance of NADPH oxidases.