Edward Bullmore - Böcker

”Den inflammerade hjärnan är humanistisk, inspirerande måste-läsning. Edward Bullmore visar hur själ och kropp hänger ihop, och en länk går via immunsystemet. Det här är revolution på riktigt.”Maria Borelius, vetenskapsjournalist och författare till Hälsorevolutionen

Depression hör snart till de vanligaste sjukdomarna i världen. Trots det har behandlingen inte förändrats nämnvärt de senaste decennierna. Men det finns hopp. I den här omvälvande boken avslöjar den framstående forskaren Edward Bullmore den banbrytande vetenskapen om sambandet mellan depression och inflammation i kroppen. Det här innebär helt nya möjligheter att bekämpa psykisk ohälsa.

"På ett imponerande sätt berättar författaren om sin forskning och förklarar komplexa teorier på ett förståeligt sättför en bred krets av läsare. Hans förklaringsmodell ger hopp inför framtida nya behandlingar."BTJ

Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. Winner of the 2017 PROSE Award in Biomedicine & Neuroscience and the 2017 British Medical Association (BMA) Award in Neurology Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain

The rapidly growing field of immunopsychiatry combines expertise and insights from immunology, psychiatry and neuroscience to understand the role of inflammation and other immune processes in causing and treating mental illness. This represents a major shift in mental health science, traditionally focused on psychological and neuronal mechanisms of depression, psychosis and dementia. This book provides the first comprehensive overview of recent, inter-disciplinary research linking disordered function of the immune system to the brain and mental illness. It offers a broad and deep perspective on the implications of immune system involvement in psychiatric disorders, including a balanced focus on basic science and clinical applications. Chapters cover the scientific evidence linking immune processes to major mental illnesses such as schizophrenia, depression, anxiety and dementia. An invaluable guide for graduate students, doctors in training, scientific researchers and others interested in the link between the immune system and mental health.

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping.Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping.Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

Worldwide, depression will be the single biggest cause of disability in the next 20 years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still... until now. In this game-changing book, University of Cambridge Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress, inflammation and depression.The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into the story of Western medicine, how we have got it wrong as well as right in the past, and how we could start getting to grips with depression and other mental disorders much more effectively in the future.'Suddenly an expert who wants to stop and question everything we thought we knew... This is a lesson in the workings of the brain far too important to ignore.' - Jeremy Vine, BBC 'Professor Bullmore explores how the current division between Psychiatry and the rest of medicine has developed and how we might change that. He puts forward a fascinating theory that attributes depression to inflammation rather than serotonin imbalance as has traditionally been thought. Whatever the truth, this book is a stimulating and interesting read.' - Wendy Burn, President Royal College of Psychiatrists'A great read, this thought provoking book presents inflammation as the major driver of depression. A real page turner that raises important questions for us all, including, how we should practise medicine going forwards and can we restart Research and Development using this paradigm? Highly recommended. - Dame Sally Davies, Chief Medical Officer for England

"A brilliant history of psychiatric ideas which suggests we are on the cusp of a transformation in our understanding of severe mental illness." The GuardianFor centuries, mental and physical health have been divided, and disorders of the mind and body have been treated as if they were poles apart. But what if this mind/body split is not only outdated - but dangerously misleading?In this groundbreaking book, psychiatrist and neuroscientist Edward Bullmore confronts one of medicine's most enduring assumptions. Through the lens of schizophrenia - perhaps the most misunderstood of all psychiatric disorders - he lifts the lid on psychiatry's dark past. He highlights how the horror of the Nazi eugenics programme magnified a split between brain and mind theories which persists to this day.Illuminated by his personal experiences and the latest scientific research, The Divided Mind builds the case for a radical rethink of how we understand, and treat, so-called "mental" illness in the 21st century.

"A brilliant history of psychiatric ideas which suggests we are on the cusp of a transformation in our understanding of severe mental illness." The GuardianFor centuries, mental and physical health have been divided, and disorders of the mind and body have been treated as if they were poles apart. But what if this mind/body split is not only outdated - but dangerously misleading?In this groundbreaking book, psychiatrist and neuroscientist Edward Bullmore confronts one of medicine's most enduring assumptions. Through the lens of schizophrenia - perhaps the most misunderstood of all psychiatric disorders - he lifts the lid on psychiatry's dark past. He highlights how the horror of the Nazi eugenics programme magnified a split between brain and mind theories which persists to this day.Illuminated by his personal experiences and the latest scientific research, The Divided Mind builds the case for a radical rethink of how we understand, and treat, so-called "mental" illness in the 21st century.