Efraim Racker – författare

Cell Biology and Immunology of Leukocyte Function is a collection of papers presented at the 12th International Leukocyte Culture Conference, held in Beersheba, Israel on June 1978. This book is organized into seven parts encompassing 111 chapters. The contributors cover the different aspects of cell biology and immunology and the unique leukocyte function. Part I describes the mechanism of lymphocyte activation, the structure and function of the plasma membrane, and the macromolecular synthesis during lymphocyte activation. This part also deals with the interaction of lymphocytes with mitogenic lectins, the comparison of the mitogenic and nonmitogenic lectin binding, and the role of macrophages in the response of lymphocytes to lectins. Part II explores the thymic factors and the development of characteristic markers, antigens, and receptors. This part particularly emphasizes lymphocyte differentiation. Parts III and IV examine the genetic control and intercellular interactions involved in leukocyte function and the parameters of the immune response under in vitro conditions. Chapters on cytotoxicity, the mechanisms of phagocytic killing, autoimmunity, and the responses of leukocytes to tumor cells are included in these parts. Part V discusses the interactions of viruses and leukocytes and provides data on the physical mapping and analysis of sarcoma and leukemia viruses, while Part VI considers the application of leukocyte culture to problems of clinical medicine. Part VII involves the study of radiation effects, with an emphasis on the application of total lymphoid irradiation to the induction of transplantation tolerance. This part also looks into the role of the DNA repair process. Cell biologists, immunologists, and biomedical scientists and researchers will greatly benefit from this book.

Reconstitutions of Transporters, Receptors, and Pathological States presents 12 lectures on the resolution and reconstitution of transporters, receptors, and pathological states. Lecture 1 discusses the reconstitution of soluble pathways, and the resolution and reconstitution of membrane complexes. Lecture 2 covers the solubilization and purification of membrane proteins. Lecture 3 explains the functions of protein and phospholipid components; the role of asymmetry; and measurement of scrambling during reconstitution. Lecture 4 presents analyses of reconstituted vesicles while Lectures 5 and 6 examine the properties of F1 and E1E2 pumps, respectively. Lecture 7 focuses on ATP-driven H+ fluxes in organelles and ATP-driven ion pumps of microorganisms and plants. Lecture 8 covers the reconstitution of the mitochondrial electron transport chain; reconstitution of photosynthetic electron transport pathways; and bacteriorhodopsin and halorhodopsin. Lecture 9 discusses the transporters of plasma membranes, mithchondria, and organelles. Lecture 10 deals with plasma membrane receptors. Lecture 11 focuses on the malignant transformation of cells while Lecture 12 speculates on the future of reconstitutions.

A New Look at Mechanisms in Bioenergetics features eight lectures based on the Robbins Lectures given at Pomona College in April 1973. These lectures are based mainly on the author''s own laboratory work and are intended for students of biology and biochemistry who want to devote their lives to research. Lecture 1 presents some of the general lessons learned from research in the field of bioenergetics. It also discusses methods for measuring oxidative phosphorylation and the resolution of soluble multienzyme systems. Lecture 2 explains the biochemical approach to the problem of photophosphorylation. Lecture 3 considers the intersection of oxidative phosphorylation and membranology. Lecture 4 discusses the coupling device and its partial reactions. Lecture 5 focuses on the oxidation chain in mitochondria. Lecture 6 discusses the resolution and reconstitution of oxidative phosphorylation. Lecture 7 examines the reconstitution of ion pumps. Finally, Lecture 8 covers oxidation control in glycolysis; the high aerobic glycolysis of tumor cells; ATPases in tumor cells; and the repair of ion pumps in tumor cells.

In the informal language of letters to public officials, Efraim Racker argues in favor of basic research as the most effective path to the treatment of disease. He contends that knowledge of the fundamentals of biological and biochemical processes is essential if we are to gain an understanding of disease processes. He then shows how this understanding is necessary for a rational approach to the prevention and cure of disease. Originally published in 1979. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

In the informal language of letters to public officials, Efraim Racker argues in favor of basic research as the most effective path to the treatment of disease. He contends that knowledge of the fundamentals of biological and biochemical processes is essential if we are to gain an understanding of disease processes. He then shows how this understanding is necessary for a rational approach to the prevention and cure of disease. Originally published in 1979. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

In the informal language of letters to public officials, Efraim Racker argues in favor of basic research as the most effective path to the treatment of disease. He contends that knowledge of the fundamentals of biological and biochemical processes is essential if we are to gain an understanding of disease processes. He then shows how this understanding is necessary for a rational approach to the prevention and cure of disease.Originally published in 1979.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Reconstitutions of Transporters, Receptors, and Pathological States presents lectures about the reconstitutions of transporters, receptors, and pathological states. The book discusses the principles and strategies of the resolution and reconstitution of soluble pathways and membrane complexes; and lessons in the resolution and reconstitution after the natural structure of the membrane has been destroyed. The text then describes the analyses of reconstituted vesicles; the ATP synthetase of oxidative phosphorylation; and the Ε1Ε2 pumps of plasma membranes. The ATP-driven ion pumps in organelles, microorganisms, and plants; the proton motive force generators, electron transport chains, and bacteriorhodopsin; and facilitated diffusion, symporters, and antiporters are also considered. The book further tackles plasma membrane receptors, as well as the reconstitutions of pathological states. Biochemists, molecular biologists, and cell biologists will find the book invaluable.

A New Look at Mechanisms in Bioenergetics is a collection of lectures given at the Robbins Lectures at Pomona College in April, 1973. The lectures contained in the book are based on laboratory works on oxidative phosphorylation. The text starts by defining oxidative phosphorylation, and after which, began a series of discussions on the biochemical approach to the problem of photophosphorylation; functions and structure of membranes and the mechanism of phosphorylation coupled to electron transport; and the basic principle of the control that governs both glycolysis and oxidation. Biochemists and biologists will find the book interesting and amusing.