Synthesis and Operability Strategies for Computer-Aided Modular Process intensification presents state-of-the-art methodological developments and real-world applications for computer-aided process modeling, optimization and control, with a particular interest on process intensification systems. Each chapter consists of basic principles, model formulation, solution algorithm, and step-by-step implementation guidance on key procedures. Sections cover an overview on the current status of process intensification technologies, including challenges and opportunities, detail process synthesis, design and optimization, the operation of intensified processes under uncertainty, and the integration of design, operability and control.

Advanced operability analysis, inherent safety analysis, and model-based control strategies developed in the community of process systems engineering are also introduced to assess process operational performance at the early design stage.

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems 

This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients.

Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more.

This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems 

This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients.

Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more.

This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

Recent developments in multi-parametric optimization and control

Multi-Parametric Optimization and Control provides comprehensive coverage of recent methodological developments for optimal model-based control through parametric optimization. It also shares real-world research applications to support deeper understanding of the material.

Researchers and practitioners can use the book as reference. It is also suitable as a primary or a supplementary textbook. Each chapter looks at the theories related to a topic along with a relevant case study. Topic complexity increases gradually as readers progress through the chapters. The first part of the book presents an overview of the state-of-the-art multi-parametric optimization theory and algorithms in multi-parametric programming. The second examines the connection between multi-parametric programming and model-predictive control—from the linear quadratic regulator over hybrid systems to periodic systems and robust control.

The third part of the book addresses multi-parametric optimization in process systems engineering. A step-by-step procedure is introduced for embedding the programming within the system engineering, which leads the reader into the topic of the PAROC framework and software platform. PAROC is an integrated framework and platform for the optimization and advanced model-based control of process systems.

An appendix summarizes the history of multi-parametric optimization algorithms. It also covers the use of the parametric optimization toolbox (POP), which is comprehensive software for efficiently solving multi-parametric programming problems.

Recent developments in multi-parametric optimization and control

Multi-Parametric Optimization and Control provides comprehensive coverage of recent methodological developments for optimal model-based control through parametric optimization. It also shares real-world research applications to support deeper understanding of the material.

Researchers and practitioners can use the book as reference. It is also suitable as a primary or a supplementary textbook. Each chapter looks at the theories related to a topic along with a relevant case study. Topic complexity increases gradually as readers progress through the chapters. The first part of the book presents an overview of the state-of-the-art multi-parametric optimization theory and algorithms in multi-parametric programming. The second examines the connection between multi-parametric programming and model-predictive control—from the linear quadratic regulator over hybrid systems to periodic systems and robust control.

The third part of the book addresses multi-parametric optimization in process systems engineering. A step-by-step procedure is introduced for embedding the programming within the system engineering, which leads the reader into the topic of the PAROC framework and software platform. PAROC is an integrated framework and platform for the optimization and advanced model-based control of process systems.

An appendix summarizes the history of multi-parametric optimization algorithms. It also covers the use of the parametric optimization toolbox (POP), which is comprehensive software for efficiently solving multi-parametric programming problems.

Optimization, simulation and control play an increasingly important role in science and industry. Because of their numerous applications in various disciplines, research in these areas is accelerating at a rapid pace.

This volume brings together the latest developments in these areas of research as well as presents applications of these results to a wide range of real-world problems. The book is composed of invited contributions by experts from around the world who work to develop and apply new optimization, simulation and control techniques either at a theoretical level or in practice. Some key topics presented include: equilibrium problems, multi-objective optimization, variational inequalities, stochastic processes, numerical analysis, optimization in signal processing, and various other interdisciplinary applications.

This volume can serve as a useful resource for researchers, practitioners, and advanced graduate students of mathematics and engineering working in research areas where results in optimization, simulation and control can be applied.

This book presents a comprehensive optimization-based theory and framework that exploits the synergistic interactions and tradeoffs between process design and operational decisions that span different time scales. Conventional methods in the process industry often isolate decision making mechanisms with a hierarchical information flow to achieve tractable problems, risking suboptimal, even infeasible operations. In this book, foundations of a systematic model-based strategy for simultaneous process design, scheduling, and control optimization is detailed to achieve reduced cost and improved energy consumption in process systems. The material covered in this book is well suited for the use of industrial practitioners, academics, and researchers.

In Chapter 1, a historical perspective on the milestones in model-based design optimization techniques is presented along with an overview of the state-of-the-art mathematical tools to solve the resulting complex problems. Chapters 2 and 3 discuss two fundamental concepts that are essential for the reader. These concepts are (i) mixed integer dynamic optimization problems and two algorithms to solve this class of optimization problems, and (ii) developing a model based multiparametric programming model predictive control. These tools are used to systematically evaluate the tradeoffs between different time-scale decisions based on a single high-fidelity model, as demonstrated on (i) design and control, (ii) scheduling and control, and (iii) design, scheduling, and control problems. We present illustrative examples on chemical processing units, including continuous stirred tank reactors, distillation columns, and combined heat and power regeneration units, along with discussions of other relevant work in the literature for each class of problems.

Synthesis and Operability Strategies for Computer-Aided Modular Process intensification presents state-of-the-art methodological developments and real-world applications for computer-aided process modeling, optimization and control, with a particular interest on process intensification systems. Each chapter consists of basic principles, model formulation, solution algorithm, and step-by-step implementation guidance on key procedures. Sections cover an overview on the current status of process intensification technologies, including challenges and opportunities, detail process synthesis, design and optimization, the operation of intensified processes under uncertainty, and the integration of design, operability and control.

Advanced operability analysis, inherent safety analysis, and model-based control strategies developed in the community of process systems engineering are also introduced to assess process operational performance at the early design stage.

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems 

This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients.

Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more.

This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems 

This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients.

Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more.

This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

Recent developments in multi-parametric optimization and control

Multi-Parametric Optimization and Control provides comprehensive coverage of recent methodological developments for optimal model-based control through parametric optimization. It also shares real-world research applications to support deeper understanding of the material.

Researchers and practitioners can use the book as reference. It is also suitable as a primary or a supplementary textbook. Each chapter looks at the theories related to a topic along with a relevant case study. Topic complexity increases gradually as readers progress through the chapters. The first part of the book presents an overview of the state-of-the-art multi-parametric optimization theory and algorithms in multi-parametric programming. The second examines the connection between multi-parametric programming and model-predictive control—from the linear quadratic regulator over hybrid systems to periodic systems and robust control.

The third part of the book addresses multi-parametric optimization in process systems engineering. A step-by-step procedure is introduced for embedding the programming within the system engineering, which leads the reader into the topic of the PAROC framework and software platform. PAROC is an integrated framework and platform for the optimization and advanced model-based control of process systems.

An appendix summarizes the history of multi-parametric optimization algorithms. It also covers the use of the parametric optimization toolbox (POP), which is comprehensive software for efficiently solving multi-parametric programming problems.

Recent developments in multi-parametric optimization and control

Multi-Parametric Optimization and Control provides comprehensive coverage of recent methodological developments for optimal model-based control through parametric optimization. It also shares real-world research applications to support deeper understanding of the material.

Researchers and practitioners can use the book as reference. It is also suitable as a primary or a supplementary textbook. Each chapter looks at the theories related to a topic along with a relevant case study. Topic complexity increases gradually as readers progress through the chapters. The first part of the book presents an overview of the state-of-the-art multi-parametric optimization theory and algorithms in multi-parametric programming. The second examines the connection between multi-parametric programming and model-predictive control—from the linear quadratic regulator over hybrid systems to periodic systems and robust control.

The third part of the book addresses multi-parametric optimization in process systems engineering. A step-by-step procedure is introduced for embedding the programming within the system engineering, which leads the reader into the topic of the PAROC framework and software platform. PAROC is an integrated framework and platform for the optimization and advanced model-based control of process systems.

An appendix summarizes the history of multi-parametric optimization algorithms. It also covers the use of the parametric optimization toolbox (POP), which is comprehensive software for efficiently solving multi-parametric programming problems.

Optimization, simulation and control play an increasingly important role in science and industry. Because of their numerous applications in various disciplines, research in these areas is accelerating at a rapid pace.

This volume brings together the latest developments in these areas of research as well as presents applications of these results to a wide range of real-world problems. The book is composed of invited contributions by experts from around the world who work to develop and apply new optimization, simulation and control techniques either at a theoretical level or in practice. Some key topics presented include: equilibrium problems, multi-objective optimization, variational inequalities, stochastic processes, numerical analysis, optimization in signal processing, and various other interdisciplinary applications.

This volume can serve as a useful resource for researchers, practitioners, and advanced graduate students of mathematics and engineering working in research areas where results in optimization, simulation and control can be applied.

This book presents a comprehensive optimization-based theory and framework that exploits the synergistic interactions and tradeoffs between process design and operational decisions that span different time scales. Conventional methods in the process industry often isolate decision making mechanisms with a hierarchical information flow to achieve tractable problems, risking suboptimal, even infeasible operations. In this book, foundations of a systematic model-based strategy for simultaneous process design, scheduling, and control optimization is detailed to achieve reduced cost and improved energy consumption in process systems. The material covered in this book is well suited for the use of industrial practitioners, academics, and researchers.

In Chapter 1, a historical perspective on the milestones in model-based design optimization techniques is presented along with an overview of the state-of-the-art mathematical tools to solve the resulting complex problems. Chapters 2 and 3 discuss two fundamental concepts that are essential for the reader. These concepts are (i) mixed integer dynamic optimization problems and two algorithms to solve this class of optimization problems, and (ii) developing a model based multiparametric programming model predictive control. These tools are used to systematically evaluate the tradeoffs between different time-scale decisions based on a single high-fidelity model, as demonstrated on (i) design and control, (ii) scheduling and control, and (iii) design, scheduling, and control problems. We present illustrative examples on chemical processing units, including continuous stirred tank reactors, distillation columns, and combined heat and power regeneration units, along with discussions of other relevant work in the literature for each class of problems.