Ellen Rothenberg – författare

This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and receptors that mediate interactions between progenitor and cells comprising the stromal microenvironment, and demonstrate which are the triggering receptors, signaling pathways, and the developmental checkpoints controlling correct development of B- and T-cells. There is also a comparison of the vital roles of transcription factor combinations in establishing cell identity in the erythroid, myeloid, B, and T lineages. By juxtaposing the insights and approaches normally confined to either immunology or hematology, this important book will help spark the growth of new research initiatives at the intersection of these two fields.

Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.