Enno Freye – Författare

In spite of today's increasing body of knowledge in regard to central nervous func­ tion and/or the mode of action of centrally active compounds, little is done to monitor those patients which are at risk of cerebral lesions either in the OR or in the ICU. Due to the inconsistency of reports regarding the application and the benefits computerized EEG and/or evoked potential monitoring will bring to the clinician, physicians still are reluctant to get involved with a technique, which they think, will have little or no effect on the outcome of a patients well being. However, due to the development in computer technology, data acquisition and comprehension, it now is possible to monitor such a viable organ as the Central Nervous System (CNS) on a routine base without being a specialist in neurology or electroencephalography. Thus, the book is intended to guide the clinician to use BEG and evoked potential monitoring in a day to day situation, without going too deep into technical details. As an improvement of cerebral care is needed, various representative cases underline the interpretation of EEG power spectra and evoked potential changes in regard to the underlying clinical situation. It is hoped that this book will serve as a guide to anyone who considers cerebral monitoring a necessity in today's patient care. This may be the anesthesiologist, the intensive care therapist, the nurse anesthetist as well as the medical personnel in the lCU setting.

This comprehensive volume will serve as a complete guide to the clinical application of computer assisted systems in monitoring central nervous functions both in the OR and ICU. It presents practical guidelines and therapeutic indications for computerized EEG and Somatosensory Evoked Potential (SSEP) monitoring for the experienced user as well as the novice, leading the newcomer step-by-step to a level of advanced monitoring. Basic procedures and data handling are explained in a user-friendly and practical way.The book also describes what cerebral monitoring can do and what its limitations are. In addition, proper selection of the available monitoring devices, set-up procedures, the technique of electrode placement, trouble shooting and data interpretation are fully covered. Various typical cases underline how EEG power spectra and evoked potential changes are interpreted, how they are used in the light of other variables being measured how they can serve to get a deeper insight into the underlying clinical situation. In this respect representative and color illustrated examples further emphasize the link between this book and clinical practice.

Provides a review of the theoretical knowledge and scope of opioid pharmacotherapy in pain medicine.

Mehr als 80?% aller chronischen Erkrankungen sind vermeidbar, wenn der Patient hinreichend darauf hingewiesen und an die Hand genommen wird, dagegen auch selber etwas zu unternehmen. Zellul�ren Organellen, die Mitochondrien, werden durch Umweltgifte und chemische Zusatzstoffe in Nahrungsmitteln beeintr�chtigt und k�nnen durch pr�ventive Ma�nahmen und� Strategien Erkrankungen wie Krebs, Diabetes, Depression, Bluthochdruck, Alzheimer, Parkinson und viele weitere neurodegenerativen Krankheitsformen verhindern helfen.

Der urs�chlich gest�rte Stickoxid-Peroxynitrit-Zyklus (NO/ONOO-) und die daraus entstehenden Effekte auf die mitochondriale Energieproduktion werden� im Detail dargestellt und evidenzbasierte Ergebnisse erl�utert.

Ziel ist, die Bedeutung dieser ver�nderten Vorg�nge in den Mitochondrien bewusst zu machen, das Augenmerk auf die Ursache einer Erkrankung zu richten, sowie das Verst�ndnis f�r alle Mitochondriopathie-bedingten Erkrankungen dem Arzt und seinem Patienten n�her zu bringen.

Finally - a book that covers all aspects of the illicit use of cocaine, amphetamines, ecstasy and/or designer drugs such as GHB, written by two experts in their field. The use of these drugs remains a continuous threat in health and medical care delivery, and this book will be an essential asset to the physician who may have to face the evaluation of patients whose use of these drugs compromises an effective treatment plan for other health issues.The book has been conceived to fill the void in existing physician reference materials, and provides a comprehensive review of the theoretical knowledge and scope of pharmacotherapy in individuals who are hooked on a psychoactive substance.While detailed scientific information is obtainable in other major articles, the book's straightforward format and style, along with its illustrations, will make for easy reading as emphasis is put on information specifically related to drugs that occur most abused in today’s society. The information provided is based on clinical practice rather than pure experimental data, which will give the physician more effective tools useful in their daily practice. Many mechanisms of action of abuse are described in detail and references are provided to direct the reader to further sources for additional information.As a special feature, the book incorporates uncluttered tables and charts, which result in immediate clarification of the mode of action on the central nervous system and the reason for misuse, thus avoiding usual long and fatiguing text in common reference books. The book aims to give the reader a clear and concise plan on what to do when being faced with an overdose situation.A well-organized Table of Contents rapidly leads the reader from general pharmacological issues to the specific overdose syndrome and its management. Additionally, significant emphasis is placed on the practical do's and don’ts for physicians, with special reference to thepredictive signs of aberrant drug-related behavior and the identification of the drug diverter by using urine drug screening.

The book centers on the treatment of pain using the appropriate opioid and a suitable co-medication whenever necessary. While many physicians or health care providers either subscribe or advocate analgesics in response to a painful situation, their basic knowledge when and how to apply them frequently is scarce. And often there is a lack of sufficient knowledge on their potential side-effects, their mode of action, 2+ their possible interactions with other agents such as ß-blockers, Ca -antagonists, ACE inhibitors and/or benzodiazepines. In addition, not all analgesics are equivalent or equally proficient at alleviating certain painful ailments. Although there have been many of articles and books written on the subject of effective pain treatment, very few have centered on the rational use of opioids. In fact opiophobia is still around with some caregivers who consider an opioid not to be the first-line drug in severe pain. On the contrary, the myth is still around that an opioid is potentially dangerous even when used in serious painful situations, and although the WHO has stated that opioids are elementary in therapeutic strategy taking into account that they are used by mouth, by the ladder, at fixed time intervals and advocating a time consistent release formulation, they are not available in every country.

Finally - a book that covers all aspects of the illicit use of cocaine, amphetamines, ecstasy and/or designer drugs such as GHB, written by two experts in their field. The use of these drugs remains a continuous threat in health and medical care delivery, and this book will be an essential asset to the physician who may have to face the evaluation of patients whose use of these drugs compromises an effective treatment plan for other health issues.The book has been conceived to fill the void in existing physician reference materials, and provides a comprehensive review of the theoretical knowledge and scope of pharmacotherapy in individuals who are hooked on a psychoactive substance.While detailed scientific information is obtainable in other major articles, the book's straightforward format and style, along with its illustrations, will make for easy reading as emphasis is put on information specifically related to drugs that occur most abused in today’s society. The information provided is based on clinical practice rather than pure experimental data, which will give the physician more effective tools useful in their daily practice. Many mechanisms of action of abuse are described in detail and references are provided to direct the reader to further sources for additional information.As a special feature, the book incorporates uncluttered tables and charts, which result in immediate clarification of the mode of action on the central nervous system and the reason for misuse, thus avoiding usual long and fatiguing text in common reference books. The book aims to give the reader a clear and concise plan on what to do when being faced with an overdose situation.A well-organized Table of Contents rapidly leads the reader from general pharmacological issues to the specific overdose syndrome and its management. Additionally, significant emphasis is placed on the practical do's and don’ts for physicians, with special reference to thepredictive signs of aberrant drug-related behavior and the identification of the drug diverter by using urine drug screening.

This comprehensive volume will serve as a complete guide to the clinical application of computer assisted systems in monitoring central nervous functions both in the OR and ICU. It presents practical guidelines and therapeutic indications for computerized EEG and Somatosensory Evoked Potential (SSEP) monitoring for the experienced user as well as the novice, leading the newcomer step-by-step to a level of advanced monitoring. Basic procedures and data handling are explained in a user-friendly and practical way.The book also describes what cerebral monitoring can do and what its limitations are. In addition, proper selection of the available monitoring devices, set-up procedures, the technique of electrode placement, trouble shooting and data interpretation are fully covered. Various typical cases underline how EEG power spectra and evoked potential changes are interpreted, how they are used in the light of other variables being measured how they can serve to get a deeper insight into the underlying clinical situation. In this respect representative and color illustrated examples further emphasize the link between this book and clinical practice.