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This book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the zona pellucida domain protein family, which impact pathologies such as infertility, deafness, and cancer. Furthermore it: Details information about the structure and function of the ZP domain in ZPDC-proteinsProvides illustrations of the organization of ZPDC-proteins, the genes that encode the proteins, and examples of mutations in the ZP domain that cause diseasesSpeculates as to the evolution of the ZP domain and potential therapeutics for diseases stemming from ZP domain mutationsAddresses mammalian and non-mammalian systems