Francesco Paolucci – författare

This book introduces the reader in the fast-developing, fascinating field of Electrochemiluminescence (ECL) imaging and ECL microscopy (ECLM) with its outstanding ability to visualize micro-objects, such as bio-conjugated magnetic beads, cellular membranes, subcellular components, tissues, polypeptide interactions and nucleic acid structures, with unprecedented sensitivity and spatial and temporal resolution. The reader is provided with the most recent fundamental and instrumental aspects of ECLM, including the strategies for signal enhancement and approaches to super-resolution and mechanistic investigations aimed at highlighting hidden ECL which may eventually facilitate the enhancement of its bioanalytical performance. By including contributions from the principal authors worldwide in the field of ECLM and ECL imaging, this book offers a breadth of coverage and depth of treatment to this new exciting field. It provides a comprehensive view of ECLM as a reference text for advanced researchers. At the same time, the fundamentals of ECL are also described so as to make it fully accessible to beginners and students. In doing this, the authors put their best efforts to describe the processes in the most straightforward way while never neglecting the rigor that distinguish the physical-chemistry of the electrogenerated chemiluminescence phenomena. The final result is a multidisciplinary resource that encompasses electrochemistry, material chemistry, physics, chemistry and biology that sets the reference, from fundamentals to application, for a wide range of scientist in an effort to foster this fascinating research into new and creative pathways.

This book introduces the reader in the fast-developing, fascinating field of Electrochemiluminescence (ECL) imaging and ECL microscopy (ECLM) with its outstanding ability to visualize micro-objects, such as bio-conjugated magnetic beads, cellular membranes, subcellular components, tissues, polypeptide interactions and nucleic acid structures, with unprecedented sensitivity and spatial and temporal resolution. The reader is provided with the most recent fundamental and instrumental aspects of ECLM, including the strategies for signal enhancement and approaches to super-resolution and mechanistic investigations aimed at highlighting hidden ECL which may eventually facilitate the enhancement of its bioanalytical performance. By including contributions from the principal authors worldwide in the field of ECLM and ECL imaging, this book offers a breadth of coverage and depth of treatment to this new exciting field. It provides a comprehensive view of ECLM as a reference text for advanced researchers. At the same time, the fundamentals of ECL are also described so as to make it fully accessible to beginners and students. In doing this, the authors put their best efforts to describe the processes in the most straightforward way while never neglecting the rigor that distinguish the physical-chemistry of the electrogenerated chemiluminescence phenomena. The final result is a multidisciplinary resource that encompasses electrochemistry, material chemistry, physics, chemistry and biology that sets the reference, from fundamentals to application, for a wide range of scientist in an effort to foster this fascinating research into new and creative pathways.

As a contribution to the search for suitable and sustainable solutions to finance rising medical care expenditures, the book proposes a typology of healthcare financing and insurance schemes, based on the dimensions of basic vs. supplementary services and mandatory vs. voluntary coverage, to analyse the design and the complex interactions between various financing and insurance arrangements in several OECD countries. This study provides a better understanding of the strengths and weaknesses of the financial and organisational structures of different countries’ healthcare financing and insurance schemes. Its main contributions are the development of a novel and rigorous theoretical framework analysing the economic rationales for the optimal design of healthcare financing and insurance schemes, and an empirical and institutional analysis investigating the consequences for efficiency and affordability of the complex interactions between basic and supplementary sources of financing.

As a contribution to the search for suitable and sustainable solutions to finance rising medical care expenditures, the book proposes a typology of healthcare financing and insurance schemes, based on the dimensions of basic vs. supplementary services and mandatory vs. voluntary coverage, to analyse the design and the complex interactions between various financing and insurance arrangements in several OECD countries. This study provides a better understanding of the strengths and weaknesses of the financial and organisational structures of different countries’ healthcare financing and insurance schemes. Its main contributions are the development of a novel and rigorous theoretical framework analysing the economic rationales for the optimal design of healthcare financing and insurance schemes, and an empirical and institutional analysis investigating the consequences for efficiency and affordability of the complex interactions between basic and supplementary sources of financing.

The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science.The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.

The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science.The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.