Francis Ali-Osman – författare
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3 produkter
3 produkter
Inbunden, Engelska, 2004
2 238 kr
Skickas inom 10-15 vardagar
A comprehensive guide for both scientists and clinicians to recent advances in our understanding of the cellular and molecular processes involved in the initiation, progression, and clinical and biological behavior of brain tumors. The authors review the latest findings on the molecular biology, genetics, epidemiology, and pathology of brain tumors, detailing new knowledge about molecular profiling, molecular pathology and classification, in vitro and in vivo brain tumor models, brain metastasis, and progenitor cell biology. They also discuss in depth the cellular and genetic pathways involved in brain oncogenesis, malignant progression, and therapeutic response, highlighting oncogenes and tumor suppressor genes, DNA damage and repair, invasion and migration, cell cycle, growth factors, signaling, apoptosis, and developmental biology. The discussion of brain tumor therapy focuses on advances in pharmacological thinking, therapeutic modalities, novel therapeutic targets, rational drug design, gene and viral therapies, drug delivery and the blood brain barrier, immunotherapy, and brain imaging.
3 328 kr
Skickas
The text presents the major scientific advances and developments in brain tumor research of the last two decades. What sets Brain Tumors apart from other existing texts is that it focuses on recent research advances, instead of addressing preexisting material. The first section is devoted to molecular genetics, molecular epidemiology, pathology, and immunology of brain tumors, while the second section focuses on the cellular and genetic pathways involved in brain oncogenes, malignant progression and therapeutic response. The third section cover therapeutic approaches to brain tumors. Topics discussed include DNA damage and repair, invasion and migration, signaling, and apoptosis, as well as areas relevant to brain tumor therapy, advances in pharmacological concepts and therapeutic modalities. This volume provides the established brain tumor scientist and clinician, as well as the new investigator, graduate, or undergraduate student, a comprehensive up-to-date guide to the critical research topics in the ever-evolving area of neuro-oncology.
Häftad, Engelska, 2010
2 238 kr
Skickas inom 10-15 vardagar
Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.