Francis Ali-Osman - Böcker

A comprehensive guide for both scientists and clinicians to recent advances in our understanding of the cellular and molecular processes involved in the initiation, progression, and clinical and biological behavior of brain tumors. The authors review the latest findings on the molecular biology, genetics, epidemiology, and pathology of brain tumors, detailing new knowledge about molecular profiling, molecular pathology and classification, in vitro and in vivo brain tumor models, brain metastasis, and progenitor cell biology. They also discuss in depth the cellular and genetic pathways involved in brain oncogenesis, malignant progression, and therapeutic response, highlighting oncogenes and tumor suppressor genes, DNA damage and repair, invasion and migration, cell cycle, growth factors, signaling, apoptosis, and developmental biology. The discussion of brain tumor therapy focuses on advances in pharmacological thinking, therapeutic modalities, novel therapeutic targets, rational drug design, gene and viral therapies, drug delivery and the blood brain barrier, immunotherapy, and brain imaging.

The text presents the major scientific advances and developments in brain tumor research of the last two decades. What sets Brain Tumors apart from other existing texts is that it focuses on recent research advances, instead of addressing preexisting material. The first section is devoted to molecular genetics, molecular epidemiology, pathology, and immunology of brain tumors, while the second section focuses on the cellular and genetic pathways involved in brain oncogenes, malignant progression and therapeutic response. The third section cover therapeutic approaches to brain tumors. Topics discussed include DNA damage and repair, invasion and migration, signaling, and apoptosis, as well as areas relevant to brain tumor therapy, advances in pharmacological concepts and therapeutic modalities. This volume provides the established brain tumor scientist and clinician, as well as the new investigator, graduate, or undergraduate student, a comprehensive up-to-date guide to the critical research topics in the ever-evolving area of neuro-oncology.