Frank Joachim - Böcker
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2 produkter
2 produkter
Del 10 - Series in Structural Biology
Single-particle Cryo-electron Microscopy: The Path Toward Atomic Resolution/ Selected Papers Of Joachim Frank With Commentaries
Inbunden, Engelska, 2018
2 844 kr
Skickas inom 3-6 vardagar
The book reproduces 55 of more than 300 articles written by the author, representing milestones in methods development of single-particle cryo-EM as well as important results obtained by this technique in the study of biological macromolecules and their interactions. Importantly, neither symmetries nor ordered arrangements (as in two-dimensional crystals, helical assemblies, icosahedral viruses) are required. Although the biological applications are mainly in the area of ribosome structure and function, the elucidation of membrane channel structures and their activation and gating mechanisms are represented, as well. The book is introduced by a commentary that explains the original development of concepts, describes the contributions of the author's colleagues and students, and shows how challenges were overcome as the technique matured. Along the way, the ribosome served as an example for a macromolecule with intricate structure and conformational dynamics that pose challenges for three-dimensional visualization. Toward the end of the book — bringing us to the present time — molecular structures with near-atomic resolution are presented, and a novel type of computational analysis, manifold embedding, is introduced.Single-particle cryo-EM is currently revolutionizing structural biology, presenting a powerful alternative to X-ray crystallography as a means to solve the structure of biological macromolecules. The book presents in one place a number of articles containing key advances in mathematical and computational methods leading up to the present time. Secondly, the development of the technique over the years is reflected by ever-expanding discoveries in the field of ribosome structure and function. Thirdly, as all histories of ideas, the history of concepts pertaining to this new method of visualization is fascinating all in itself.
Del 2 - Series in Structural Biology
Found In Translation: Collection Of Original Articles On Single-particle Reconstruction And The Structural Basis Of Protein Synthesis
Inbunden, Engelska, 2014
2 040 kr
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The aim of this book is to make available, to students and experts, a compendium of important articles covering (1) the development of single-article reconstruction techniques, and (2) the progress in the exploration of structural basis of translation in bacteria and eukaryotes by cryo-EM and single-particle reconstruction.For novice and expert alike, a good overview of the development of tools and the ensuing discoveries spanning almost half a century has been lacking. Review articles attempting such an endeavor normally a very limited scope. The purpose of this book is to give the reader access to a selection of original articles spanning this period, from which he or she can form his or her opinion, the introductory text serving as a guide.There is no competing book. The author has made pioneering contributions both in the development of the technique, which is now on the verge of attaining atomic resolution, and to the exploration of ribosome structure and function.Selected reprints of key papers in the development of single-particle reconstruction methods, and in the research of ribosome structure and dynamics making use of these new methods. The reprints cover the period of 1969-2013.