Frederick O. Stephens – författare

This book provides an easily understood and general overview of the basic medical, scientific, and clinical aspects of cancer. The reader will acquire a clear understanding of how and why people develop cancer, how the body reacts to cancer, what can be done to prevent the disease, and how the various cancers are best diagnosed and treated.

This book presents the full range of management techniques and practices used in induction chemotherapy – both systemic and locoregional - by experienced international groups within one accessible volume. It provides the latest information on the pioneering and cutting-edge practices employed in different institutions and documents the advantages of integrated treatment schedules. All those responsible for treating patients with locally advanced cancers may find new, interesting aspects of locoregional cancer management and will find this book to be an invaluable source of up-to-date information.Throughout the world, induction chemotherapy is being used as part of an integrated plan of management for locally advanced, solid tumors, while systemic chemotherapy is most commonly used to shrink primarily non-operable tumors. In cases of poorly or nonresponsive tumors, attempts have been made to administer chemotherapeutics via the arterial route in order to achieve higher localized drug exposure and response rates. Such therapies are being practiced worldwide in independent, remote departments in universities, teaching hospitals and clinical schools. Frequently, however, these teams remain relatively unaware of the work being done in other institutions, which may slow further progress.

This book presents the full range of management techniques and practices used in induction chemotherapy – both systemic and locoregional - by experienced international groups within one accessible volume. It provides the latest information on the pioneering and cutting-edge practices employed in different institutions and documents the advantages of integrated treatment schedules. All those responsible for treating patients with locally advanced cancers may find new, interesting aspects of locoregional cancer management and will find this book to be an invaluable source of up-to-date information.Throughout the world, induction chemotherapy is being used as part of an integrated plan of management for locally advanced, solid tumors, while systemic chemotherapy is most commonly used to shrink primarily non-operable tumors. In cases of poorly or nonresponsive tumors, attempts have been made to administer chemotherapeutics via the arterial route in order to achieve higher localized drug exposure and response rates. Such therapies are being practiced worldwide in independent, remote departments in universities, teaching hospitals and clinical schools. Frequently, however, these teams remain relatively unaware of the work being done in other institutions, which may slow further progress.

Die regionale Chemotherapie (RCT), eine örtlich auf den Tumor begrenzte Chemotherapie, kann teilweise der erste Schritt innerhalb eines umfassenden Therapieplans sein. Hier wird dem soliden Tumor das Medikament über die versorgende Arterie zugeführt mit dem Ziel, den Tumor vor der Operation zu verkleinern. Die Herausgeber und Autoren sind national und international renommierte Spezialisten auf dem Gebiet der RCT und beschäftigen sich seit vielen Jahren mit dieser Technik. Sie stellen die ganze Bandbreite der Behandlungsmöglichkeiten vor und zeigen sowohl die Vorteile als auch die Grenzen des Behandlungskonzeptes und der RCT auf: Begrenzung auf eine kleine Körperregionen; geringe Nebenwirkungen; hohe Konzentrationen des Zytostatikums lokal erreichbar; in vielen Fällen Überlegenheit der RCT gegenüber der systemischen Therapie hinsichtlich Überlebenszeit und Lebensqualität; hohe Ansprechrate vieler häufig vorkommender Krebsarten auf RCT.Vorgestellt werden alle Tumorentitäten mit guter Ansprechrate auf die RCT. Das praktische Vorgehen der Therapie wird beschrieben. Teilweise befinden sich die Therapien in der Erprobung, in diesen Fällen wird die aktuelle Studienlage diskutiert.Das Buch bietet für alle Ärzte, die Patienten mit fortgeschrittenen lokalen Tumoren betreuen, wertvolle und praxisnahe Informationen.