Fredrick M. Wigley – författare

This essential resource presents the most up-to-date information on scleroderma. A clear and concise synthesis of current concepts in pathogenesis and modern approaches to management, this book is comprised of the authoritative work of international experts. With an integrated multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. It is a valuable resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

Raynaud’s Phenomenon: A Guide to Pathogenesis and Treatment comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists alike. In the last decade, there have been important advances not only in understanding the pathophysiology of Raynaud’s Phenomenon (RP), but also in developing diagnostic methods and effective drug and non-drug therapies. Thoroughly discussing the various manifestations of RP, including childhood RP, RP secondary to connective tissue disease, and a variety of other associated disorders that include vascular perturbation that mimics RP, this title provides a wealth of new information available on normal and abnormal thermoregulation and helps physicians identify the best therapeutic approaches to treating RP. The work offers differential diagnosis options, reviews potential causes such as autoimmune disease, industrial trauma, drugs, and metabolic causes and provides clear recommendations for therapy. Engaging readers with case vignettes and a plethora of visual aids, Raynaud’s Phenomenon: A Guide to Pathogenesis and Treatment is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to physicians, patients, and individuals dealing with these disease processes.

This book comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists. Raynaud’s phenomenon is an inappropriate and exaggerated response of the digital and cutaneous circulation to cold environmental temperatures. It is common, often causing significant morbidity and it is a major challenge for physicians at every level and specialty. A comprehensive review of Raynaud’s is now timely because of the incredible progress in understanding the molecular mechanisms of the normal regulation of cutaneous blood flow and how disease can disrupt the function of these specialized vessels. Likewise, the clinical implications of Raynaud’s phenomenon are better appreciated with studies defining its prevalence, the associated diseases, and new treatment approaches for patients suffering from it. The nomenclature used to classify cases has changed over the years and is important to understand these terms both for clinical care andresearch.

This fully updated second edition comprehensively discusses various causes of Raynaud’s phenomenon including childhood Raynaud’s phenomenon, Raynaud’s phenomenon secondary to connective tissue disease, occupational causes, and a variety of other associated disorders. Careful consideration is given to the diagnosis of Raynaud’s phenomenon with state of the art discussion of nailfold capillary examination, non-invasive imaging, angiography, and appropriate serological testing. The concept that Raynaud’s phenomenon is associated with systemic disease or can be the manifestation of a systemic vasospastic disorder is also presented. In addition to reviewing both non-drug and drug therapy for patients with Raynaud’s phenomenon, this volume provides a practical approach in specific clinical situations by presenting problematic cases and the authors’ expert opinions on therapy. It also discusses mechanisms contributing to the vascular dysfunctionof primary Raynaud’s phenomenon and the vascular disease of secondary Raynaud’s phenomenon.

Engaging readers with case vignettes and a plethora of visual aids, Raynaud’s Phenomenon: From Pathogenesis to Management is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to adult and pediatric physicians, rheumatologists, and clinical and basic researchers.

Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.