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44 produkter
44 produkter
Simultaneous Global New Drug Development
Multi-Regional Clinical Trials after ICH E17
Inbunden, Engelska, 2021
2 398 kr
Skickas inom 10-15 vardagar
Global simultaneous development is becoming more necessary as the cost of developing medical products continues to grow. The strategy of using multiregional clinical trials (MRCTs) has become the preferred method for developing new medicines. Implementing the same protocol to include subjects from many geographical regions around the world, MRCTs can speed up the patient enrolment, thus resulting in quicker drug development and obtaining faster approval of the drug globally.After the publication of the editors’ first volume on this topic, there have been new developments on MRCTs. The International Council for Harmonisation (ICH) issued ICH E17, a guideline document on MRCTs, in November 2017, laying out principles on MRCTs. Beyond E17, new methodologies have been developed as well.Simultaneous Global New Drug Development: Multi-Regional Clinical Trials after ICH E17 collects chapters providing interpretations of principles in ICH E17 and new ideas of implementing MRCTs. Authors are from different regions, and from academia and industry. In addition, in contrast to the first book, new perspectives are brought to MRCT from regulatory agencies. This book will be of particular interest to biostatisticians working in late stage clinical development of medical products. It will also be especially helpful for statisticians in regulatory agencies, and medical research institutes.This book is comprehensive across the MRCT topic spectrum, includingIssues regarding ICH E17 ImplementationMRCT Design and Analysis MethodologiesPerspectives from authorities in regulatory agencies, as well as statisticians practicing in the medical product industryMany examples of real-life applications based on actual MRCTs
753 kr
Skickas inom 10-15 vardagar
Longitudinal studies often incur several problems that challenge standard statistical methods for data analysis. These problems include non-ignorable missing data in longitudinal measurements of one or more response variables, informative observation times of longitudinal data, and survival analysis with intermittently measured time-dependent covariates that are subject to measurement error and/or substantial biological variation. Joint modeling of longitudinal and time-to-event data has emerged as a novel approach to handle these issues.Joint Modeling of Longitudinal and Time-to-Event Data provides a systematic introduction and review of state-of-the-art statistical methodology in this active research field. The methods are illustrated by real data examples from a wide range of clinical research topics. A collection of data sets and software for practical implementation of the joint modeling methodologies are available through the book website.This book serves as a reference book for scientific investigators who need to analyze longitudinal and/or survival data, as well as researchers developing methodology in this field. It may also be used as a textbook for a graduate level course in biostatistics or statistics.
Simultaneous Global New Drug Development
Multi-Regional Clinical Trials after ICH E17
Häftad, Engelska, 2024
1 118 kr
Skickas inom 10-15 vardagar
Global simultaneous development is becoming more necessary as the cost of developing medical products continues to grow. The strategy of using multiregional clinical trials (MRCTs) has become the preferred method for developing new medicines. Implementing the same protocol to include subjects from many geographical regions around the world, MRCTs can speed up the patient enrolment, thus resulting in quicker drug development and obtaining faster approval of the drug globally.After the publication of the editors’ first volume on this topic, there have been new developments on MRCTs. The International Council for Harmonisation (ICH) issued ICH E17, a guideline document on MRCTs, in November 2017, laying out principles on MRCTs. Beyond E17, new methodologies have been developed as well.Simultaneous Global New Drug Development: Multi-Regional Clinical Trials after ICH E17 collects chapters providing interpretations of principles in ICH E17 and new ideas of implementing MRCTs. Authors are from different regions, and from academia and industry. In addition, in contrast to the first book, new perspectives are brought to MRCT from regulatory agencies. This book will be of particular interest to biostatisticians working in late stage clinical development of medical products. It will also be especially helpful for statisticians in regulatory agencies, and medical research institutes.This book is comprehensive across the MRCT topic spectrum, includingIssues regarding ICH E17 ImplementationMRCT Design and Analysis MethodologiesPerspectives from authorities in regulatory agencies, as well as statisticians practicing in the medical product industryMany examples of real-life applications based on actual MRCTs
647 kr
Skickas inom 10-15 vardagar
Tourism demand is the foundation on which all tourism-related business decisions ultimately rest. Governments and companies such as airlines, tour operators, hotels, cruise ship lines, and recreation facility providers are interested in the demand for their products by tourists. The success of many businesses depends largely or totally on the state of tourism demand, and ultimate management failure is quite often due to the failure to meet market demand. This book introduces students, researchers and practitioners to the modern developments in advanced econometric methodology within the context of tourism demand analysis, and illustrates these developments with actual tourism applications. The concepts and computations of modern advanced econometric modelling methodologies are introduced at a level that is accessible to specialists and non-specialists alike. The methodologies introduced include general-to-specific modelling, cointegration, vector autoregression, time varying parameter modelling, panel data analysis and the almost ideal demand system (AIDS). In order to help the reader understand the various methodologies, extensive tourism demand examples are provided throughout the volume.
2 119 kr
Skickas inom 10-15 vardagar
Tourism demand is the foundation on which all tourism-related business decisions ultimately rest. Governments and companies such as airlines, tour operators, hotels, cruise ship lines, and recreation facility providers are interested in the demand for their products by tourists. The success of many businesses depends largely or totally on the state of tourism demand, and ultimate management failure is quite often due to the failure to meet market demand. This book introduces students, researchers and practitioners to the modern developments in advanced econometric methodology within the context of tourism demand analysis, and illustrates these developments with actual tourism applications. The concepts and computations of modern advanced econometric modelling methodologies are introduced at a level that is accessible to specialists and non-specialists alike. The methodologies introduced include general-to-specific modelling, cointegration, vector autoregression, time varying parameter modelling, panel data analysis and the almost ideal demand system (AIDS). In order to help the reader understand the various methodologies, extensive tourism demand examples are provided throughout the volume.
Econometric Modelling and Forecasting of Tourism Demand
Methods and Applications
Häftad, Engelska, 2022
570 kr
Skickas inom 10-15 vardagar
This insightful and timely volume provides a succinct, expert-led introduction to the latest developments in advanced econometric methodologies in the context of tourism demand modelling and forecasting.Written by a plethora of worldwide experts on this topic, this book offers a comprehensive approach to tourism econometrics. Accurate demand forecasts are crucial to decision-making in the tourism industry and this book provides real-life tourism applications and the corresponding R code alongside theoretical foundations, in order to enhance understanding and practice amongst its readers. The methodologies introduced include general to specific modelling, cointegration, vector autoregression, time-varying parameter modelling, spatiotemporal econometric models, mixed-frequency forecasting, hybrid forecasting models, forecasting combination techniques, density forecasting, judgemental forecasting, scenario forecasting under crisis, and web-based tourism forecasting.Embellished with insightful figures and tables throughout, this book is an invaluable resource for those using advanced econometric methodologies in their studies and research, including both undergraduate and postgraduate students, researchers, and practitioners.
Econometric Modelling and Forecasting of Tourism Demand
Methods and Applications
Inbunden, Engelska, 2022
1 976 kr
Skickas inom 10-15 vardagar
This insightful and timely volume provides a succinct, expert-led introduction to the latest developments in advanced econometric methodologies in the context of tourism demand modelling and forecasting.Written by a plethora of worldwide experts on this topic, this book offers a comprehensive approach to tourism econometrics. Accurate demand forecasts are crucial to decision-making in the tourism industry and this book provides real-life tourism applications and the corresponding R code alongside theoretical foundations, in order to enhance understanding and practice amongst its readers. The methodologies introduced include general to specific modelling, cointegration, vector autoregression, time-varying parameter modelling, spatiotemporal econometric models, mixed-frequency forecasting, hybrid forecasting models, forecasting combination techniques, density forecasting, judgemental forecasting, scenario forecasting under crisis, and web-based tourism forecasting.Embellished with insightful figures and tables throughout, this book is an invaluable resource for those using advanced econometric methodologies in their studies and research, including both undergraduate and postgraduate students, researchers, and practitioners.
1 129 kr
Skickas inom 7-10 vardagar
Connecting theory with numerical techniques using MATLAB®, this practical textbook equips students with the tools required to solve finite element problems. This hands-on guide covers a wide range of engineering problems through nine well-structured chapters including solid mechanics, heat transfer and fluid dynamics; equilibrium, steady state and transient; and 1-D, 2-D and 3-D problems. Engineering problems are discussed using case study examples, which are solved using a systematic approach, both by examining the steps manually and by implementing a complete MATLAB®code. This topical coverage is supplemented by discourse on meshing with a detailed explanation and implementation of 2-D meshing algorithms. Introducing theory and numerical techniques alongside comprehensive examples this text increases engagement and provides students with the confidence needed to implement their own computer codes to solve given problems.
Theory of Nonlinear Structural Analysis
The Force Analogy Method for Earthquake Engineering
Inbunden, Engelska, 2014
1 726 kr
Skickas inom 5-8 vardagar
A comprehensive book focusing on the Force Analogy Method, a novel method for nonlinear dynamic analysis and simulationThis book focusses on the Force Analogy Method, a novel method for nonlinear dynamic analysis and simulation. A review of the current nonlinear analysis method for earthquake engineering will be summarized and explained. Additionally, how the force analogy method can be used in nonlinear static analysis will be discussed through several nonlinear static examples. The emphasis of this book is to extend and develop the force analogy method to performing dynamic analysis on structures under earthquake excitations, where the force analogy method is incorporated in the flexural element, axial element, shearing element and so on will be exhibited. Moreover, the geometric nonlinearity into nonlinear dynamic analysis algorithm based on the force analogy method is included. The application of the force analogy method in seismic design for buildings and structural control area is discussed and combined with practical engineering.
1 332 kr
Skickas inom 10-15 vardagar
Longitudinal studies often incur several problems that challenge standard statistical methods for data analysis. These problems include non-ignorable missing data in longitudinal measurements of one or more response variables, informative observation times of longitudinal data, and survival analysis with intermittently measured time-dependent covariates that are subject to measurement error and/or substantial biological variation. Joint modeling of longitudinal and time-to-event data has emerged as a novel approach to handle these issues.Joint Modeling of Longitudinal and Time-to-Event Data provides a systematic introduction and review of state-of-the-art statistical methodology in this active research field. The methods are illustrated by real data examples from a wide range of clinical research topics. A collection of data sets and software for practical implementation of the joint modeling methodologies are available through the book website.This book serves as a reference book for scientific investigators who need to analyze longitudinal and/or survival data, as well as researchers developing methodology in this field. It may also be used as a textbook for a graduate level course in biostatistics or statistics.
Parametrizations in Control, Estimation and Filtering Problems: Accuracy Aspects
Häftad, Engelska, 2011
1 064 kr
Skickas inom 10-15 vardagar
This book is all about finite wordlength errors in digital filters, con trollers and estimators, and how to minimize the deleterious effects of these errors on the performance of these devices. This does by no means imply that all about finite wordlength errors in filters, controllers and estimators is to be found in this book. We first ventured into the world of finite wordlength effects in 1987 when Gang Li began his PhD thesis in this area. Our more experienced readers might well say 'This shows', but we believe that the extent of our new contributions largely offsets our relative inexperience about the subject that might surface here and there in the book. Our naive view on the subject of finite wordlength errors in 1987 could probably be summarized as follows: • numerical errors due to finite wordlength encoding and roundoff are something that one has to live with, and there is probably not much that can be done about them except to increase the wordlength by improvements on the hardware; • these errors are as old as finite arithmetic and numerical analysis and they must therefore be well understood by now; • thus, if something can be done to minimize their effects, it must have been analysed and put into practice a long time ago. It is almost fair to say that we were wrong on all counts.
355 kr
Skickas inom 3-6 vardagar
1 577 kr
Skickas inom 3-6 vardagar
This book introduces advanced sparsity-driven models and methods and their applications in radar tasks such as detection, imaging and classification. Compressed sensing (CS) is one of the most active topics in the signal processing area. By exploiting and promoting the sparsity of the signals of interest, CS offers a new framework for reducing data without compromising the performance of signal recovery, or for enhancing resolution without increasing measurements.An introductory chapter outlines the fundamentals of sparse signal recovery. The following topics are then systematically and comprehensively addressed: hybrid greedy pursuit algorithms for enhancing radar imaging quality; two-level block sparsity model for multi-channel radar signals; parametric sparse representation for radar imaging with model uncertainty; Poisson-disk sampling for high-resolution and wide-swath SAR imaging; when advanced sparse models meet coarsely quantized radar data; sparsity-aware micro-Doppler analysis for radar target classification; and distributed detection of sparse signals in radar networks via locally most powerful test. Finally, a concluding chapter summarises key points from the preceding chapters and offers concise perspectives.The book focuses on how to apply the CS-based models and algorithms to solve practical problems in radar, for the radar and signal processing research communities.
1 726 kr
Skickas inom 3-6 vardagar
Over the last ten years, the numbers of unmanned air vehicles (UAVs) or “drones” have changed from being just a few specialist systems, used for scientific data gathering and military purposes, to them proliferating in huge numbers. They are used across a broad range of different leisure, commercial and military activities. UAVs can be used for: movement of items in factories for manufacturing, passenger and freight transportation, can take various roles in the agriculture and forestry industries (dispensing seeds, watering and monitoring crops), remote sensing for the oil and gas industries, traffic flow monitoring, support of emergency services, hobbies, security, military and many other applications.The expansion in the use of unmanned air vehicles has come about due to the development of low cost, high performance stable platforms, employing equally low-cost communication and navigation systems supplemented by simple to use software and interfaces. Therefore, there is a need to be able to monitor the rapidly changing use of airspace, especially at low and normally neglected altitudes to ensure UAVs do not compromise safety or are used for malicious purposes. Radar is the only sensor able to perform this function on a 24-hour, all weather, wide-area basis.This book, concerned with radar surveillance of UAVs, has been compiled using contributions from the leading experts around the world to create a single body of knowledge on this important, yet still emerging, topic. It is aimed at advanced students and researchers with an interest in radar systems.
1 095 kr
Skickas inom 10-15 vardagar
This edited volume presents current research in biostatistics with emphasis on biopharmaceutical applications. Featuring contributions presented at the 2017 ICSA Applied Statistics Symposium held in Chicago, IL on June 25 to 28, 2017, this book explores timely topics that have a high potential impact on statistical methodology and future research in biostatistics and biopharmaceuticals. The theme of this conference was Statistics for a New Generation: Challenges and Opportunities, in recognition of the advent of a new generation of statisticians. The conference attracted statisticians working in academia, government, and industry; domestic and international statisticians. From the conference, the editors selected 28 high-quality presentations and invited the speakers to prepare full chapters for this book. These contributions are divided into four parts: Part I Biostatistical Methodology, Part II Statistical Genetics and Bioinformatics, Part III Regulatory Statistics, and Part IV Biopharmaceutical Research and Applications.Featuring contributions on topics such as statistics in genetics, bioinformatics, biostatistical methodology, and statistical computing, this book is beneficial to researchers, academics, practitioners and policy makers in biostatistics and biopharmaceuticals.
1 095 kr
Skickas inom 10-15 vardagar
This edited volume presents current research in biostatistics with emphasis on biopharmaceutical applications. Featuring contributions presented at the 2017 ICSA Applied Statistics Symposium held in Chicago, IL on June 25 to 28, 2017, this book explores timely topics that have a high potential impact on statistical methodology and future research in biostatistics and biopharmaceuticals. The theme of this conference was Statistics for a New Generation: Challenges and Opportunities, in recognition of the advent of a new generation of statisticians. The conference attracted statisticians working in academia, government, and industry; domestic and international statisticians. From the conference, the editors selected 28 high-quality presentations and invited the speakers to prepare full chapters for this book. These contributions are divided into four parts: Part I Biostatistical Methodology, Part II Statistical Genetics and Bioinformatics, Part III Regulatory Statistics, and Part IV Biopharmaceutical Research and Applications.Featuring contributions on topics such as statistics in genetics, bioinformatics, biostatistical methodology, and statistical computing, this book is beneficial to researchers, academics, practitioners and policy makers in biostatistics and biopharmaceuticals.
Del 12274 - Lecture Notes in Computer Science
Knowledge Science, Engineering and Management
13th International Conference, KSEM 2020, Hangzhou, China, August 28–30, 2020, Proceedings, Part I
Häftad, Engelska, 2020
535 kr
Skickas inom 10-15 vardagar
This two-volume set of LNAI 12274 and LNAI 12275 constitutes the refereed proceedings of the 13th International Conference on Knowledge Science, Engineering and Management, KSEM 2020, held in Hangzhou, China, in August 2020.*The 58 revised full papers and 27 short papers were carefully reviewed and selected from 291 submissions.
Del 12275 - Lecture Notes in Computer Science
Knowledge Science, Engineering and Management
13th International Conference, KSEM 2020, Hangzhou, China, August 28–30, 2020, Proceedings, Part II
Häftad, Engelska, 2020
535 kr
Skickas inom 10-15 vardagar
This two-volume set of LNAI 12274 and LNAI 12275 constitutes the refereed proceedings of the 13th International Conference on Knowledge Science, Engineering and Management, KSEM 2020, held in Hangzhou, China, in August 2020.*The 58 revised full papers and 27 short papers were carefully reviewed and selected from 291 submissions.
535 kr
Skickas inom 10-15 vardagar
This book initially delves into its fundamentals to initiate the exploration of online incentive mechanisms in wireless communications.
551 kr
Skickas inom 10-15 vardagar
This book provides a detailed study on sources of encrypted network traffic, methods and techniques for analyzing, classifying and detecting the encrypted traffic.
517 kr
Skickas inom 5-8 vardagar
Signals and systems enjoy wide application in industry and daily life, and understanding basic concepts of the subject area is of importance to undergraduates majoring in engineering. With rigorous mathematical deduction, this introductory text book is helpful for students who study communications engineering, electrical and electronic engineering, and control engineering. Additionally, supplementary materials are provided for self-learners.
Del 8178 - Lecture Notes in Computer Science
Behavior and Social Computing
International Workshop on Behavior and Social Informatics, BSI 2013, Gold Coast, Australia, April 14-17, and International Workshop on Behavior and Social Informatics and Computing, BSIC 2013, Beijing, China, August 3-9, 2013, Revised Selected Papers
Häftad, Engelska, 2013
551 kr
Skickas inom 10-15 vardagar
This book constitutes the thoroughly refereed proceedings of the International Workshops on Behavior and Social Informatics and Computing, BSIC 2013, held as collocated event of IJCAI 2013, in Beijing, China in August 2013 and the International Workshop on Behavior and Social Informatics, BSI 2013, held as satellite workshop of PAKDD 2013, in Gold Coast, Australia, in April 2013. The 23 papers presented were carefully reviewed and selected from 58 submissions. The papers study a wide range of techniques and methods for behavior/social-oriented analyses including behavioral and social interaction and network, behavioral/social patterns, behavioral/social impacts, the formation of behavioral/social-oriented groups and collective intelligence and behavioral/social intelligence emergence.
Del 486 - IFIP Advances in Information and Communication Technology
Intelligent Information Processing VIII
9th IFIP TC 12 International Conference, IIP 2016, Melbourne, VIC, Australia, November 18-21, 2016, Proceedings
Inbunden, Engelska, 2016
551 kr
Skickas inom 10-15 vardagar
This book constitutes the refereed proceedings of the 9th IFIP TC 12 International Conference on Intelligent Information Processing, IIP 2016, held in Melbourne, VIC, Australia, in October 2016. The 24 full papers and 3 short papers presented were carefully reviewed and selected from more than 40 submissions. They are organized in topical sections on machine learning, data mining, deep learning, social computing, semantic web and text processing, image understanding, and brain-machine collaboration.
1 639 kr
Skickas inom 10-15 vardagar
It provides an approachable strategy for researchers and engineers to implement differential privacy in real world applications.Early chapters are focused on two major directions, differentially private data publishing and differentially private data analysis.
Del 10412 - Lecture Notes in Computer Science
Knowledge Science, Engineering and Management
10th International Conference, KSEM 2017, Melbourne, VIC, Australia, August 19-20, 2017, Proceedings
Häftad, Engelska, 2017
551 kr
Skickas inom 10-15 vardagar
?This book constitutes the refereed proceedings of the 10th International Conference on Knowledge Science, Engineering and Management, KSEM 2017, held in Melbourne, Australia, in August 2017. The 35 revised full papers and 12 short papers presented were carefully reviewed and selected from 134 submissions. knowledge management;
986 kr
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This book is comprised of the presentations delivered at the 25th ICSA Applied Statistics Symposium held at the Hyatt Regency Atlanta, on June 12-15, 2016. This symposium attracted more than 700 statisticians and data scientists working in academia, government, and industry from all over the world. The theme of this conference was the “Challenge of Big Data and Applications of Statistics,” in recognition of the advent of big data era, and the symposium offered opportunities for learning, receiving inspirations from old research ideas and for developing new ones, and for promoting further research collaborations in the data sciences. The invited contributions addressed rich topics closely related to big data analysis in the data sciences, reflecting recent advances and major challenges in statistics, business statistics, and biostatistics. Subsequently, the six editors selected 19 high-quality presentations and invited the speakers to prepare full chapters for this book, which showcases new methods in statistics and data sciences, emerging theories, and case applications from statistics, data science and interdisciplinary fields. The topics covered in the book are timely and have great impact on data sciences, identifying important directions for future research, promoting advanced statistical methods in big data science, and facilitating future collaborations across disciplines and between theory and practice.
Del 486 - IFIP Advances in Information and Communication Technology
Intelligent Information Processing VIII
9th IFIP TC 12 International Conference, IIP 2016, Melbourne, VIC, Australia, November 18-21, 2016, Proceedings
Häftad, Engelska, 2018
551 kr
Skickas inom 10-15 vardagar
This book constitutes the refereed proceedings of the 9th IFIP TC 12 International Conference on Intelligent Information Processing, IIP 2016, held in Melbourne, VIC, Australia, in October 2016.
Del 69 - Advances in Information Security
Differential Privacy and Applications
Häftad, Engelska, 2018
1 639 kr
Skickas inom 10-15 vardagar
It provides an approachable strategy for researchers and engineers to implement differential privacy in real world applications.Early chapters are focused on two major directions, differentially private data publishing and differentially private data analysis.
714 kr
Skickas inom 10-15 vardagar
The theme of this conference was the “Challenge of Big Data and Applications of Statistics,” in recognition of the advent of big data era, and the symposium offered opportunities for learning, receiving inspirations from old research ideas and for developing new ones, and for promoting further research collaborations in the data sciences.
Del 130 - Topics in Applied Physics
Progress in High-Efficient Solution Process Organic Photovoltaic Devices
Fundamentals, Materials, Devices and Fabrication
Inbunden, Engelska, 2015
1 592 kr
Skickas inom 10-15 vardagar
This book presents an important technique to process organic photovoltaic devices. The basics, materials aspects and manufacturing of photovoltaic devices with solution processing are explained. Solution processable organic solar cells - polymer or solution processable small molecules - have the potential to significantly reduce the costs for solar electricity and energy payback time due to the low material costs for the cells, low cost and fast fabrication processes (ambient, roll-to-roll), high material utilization etc. In addition, organic photovoltaics (OPV) also provides attractive properties like flexibility, colorful displays and transparency which could open new market opportunities. The material and device innovations lead to improved efficiency by 8% for organic photovoltaic solar cells, compared to 4% in 2005. Both academic and industry research have significant interest in the development of this technology. This book gives an overview of the booming technology, focusing on the solution process for organic solar cells and provides a state-of-the-art report of the latest developments. World class experts cover fundamental, materials, devices and manufacturing technology of OPV technology.