Gary A Silverman – författare
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2 produkter
2 produkter
Molecular And Cellular Aspects Of The Serpinopathies And Disorders In Serpin Activity
Inbunden, Engelska, 2007
3 390 kr
Tillfälligt slut
Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases.Massive thrombosis or bleeding, hereditary angioedema, Alzheimer's disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.
2 847 kr
Kommande
Neonatology is an expanding subspecialty with recent advances in treatment modalities and increased survival rates. With a better understanding of the pathogenesis of neonatal conditions, therapeutic and medical decisions are becoming more complex and require a multi-disciplinary approach. There are several handbooks of neonatology currently available but none of them offer a comprehensive guide to neonatal care. This handbook offers a unique, multi-disciplinary approach to most of the disease states encountered in the neonatal intensive care unit. It includes a special focus on prenatal care, delivery room management, transport, organ and system based neonatal disorders, a detailed approach to surgical problems in the neonatal intensive care unit and a guide to end-of-life care and ethical issues concerned.This handbook is edited and written by experts in each subspecialty, and will provide a unique, comprehensive and multi-disciplinary approach to the diagnosis and management of common neonatal problems with easy-to-follow organ system outline format.