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The entire width and depth of Vascular Medicine/Angiology are covered in a robust and comprehensive way by this textbook, based on the most recent and advanced available evidence. All topics are covered in a holistic way, including sound research background, state of the art clinical practice and carefully selected clinical paradigms. The chapters are written in a clear didactic style that facilitates learning and stimulates critical thinking and analysis, turning the reader in an active player of a masterly designed and interactive educational process. The VAS European Book on Angiology/Vascular Medicine follows the specialistic approach involving the different areas of Angiology/Vascular Medicine (synonymous in Europe) with multidisciplinary contributes, as the soundest path to solve the complex challenges faced in modern Medicine. A game changing work that facilitates the close and constructive collaboration of the expertise involved in this rapidly evolving field, in which authors adopt a patient centred care, typical of personalized medicine, with a thorough analysis of clinical and quality of life outcomes. Built as a dynamic element of the broader educational process in the field produced by VAS-European Independent Foundation in Angiology/Vascular Medicine, this textbook provides qualified synthesis for specialists in the area of Vascular Medicine but will also appeal to graduate and postgraduate students, early career researchers and clinicians alike, who are toiling in the fields of Vascular Medicine, including Lymphology, Phlebology, Microcirculation, Thrombosis, vascular Risk Factors, Preventive Medicine, extending to Vascular Surgery, Dermatology, Cardiology and vascular Neurology.The Book supports, with a European view, all the field of the Educational Actions on Vascular Medicine/Angiology and represents the suggested referee for the European Angiology/Vascular Medicine Courses, Masters and European Exams, including CESMA-UEMS diploma. This second edition of the Book is totally updated and renovated, including new chapters and authors. It maintains the same improved and enlarged effort to represent the highest European collaboration, open to international contributions. It strengthens Vascular Medicine, a core specialty for patients and the population, which is strongly linked to the reality and needs of a changing society.Chapter “104” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.