Gisela Dallenbach-Hellweg - Böcker

The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology,tumor virology,and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in op- mizing clinical management and prognosis. A new chapter on immunohistochemistry has been added,which includes refined detection methods,e. g. ,the overexpression of INK4a p16 as a molecular marker in the early differential diagnosis of premalignant - sions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cel- lar and nuclear deregulation at the molecular level. All chapters have been revised to - clude the newest advances and relevant experiences in how to interpret and manage cervical disease; they are supported by the addition of 35 new microphotographic ill- trations. The tumor nomenclature is adapted to the latest edition of the WHO classi- cation; the morphology code of the international classification of diseases for oncology (ICD-O) has been added.We have also updated the list of references by adding recent relevant publications. Again,the staff of Springer-Verlag deserve our thanks for their patience and skill in preparing the manuscript and in reproducing the microphotographs. Heidelberg,February 2005 Gisela Dallenbach-Hellweg, Magnus von Knebel Doeberitz, and Marcus J. Trunk Heading2 Preface to the First Edition During the past decade our understanding of the histopathology of the cervix uteri has changed greatly.

This new edition differs from the preceding ones in that there has been extensive revision of most chapters. Recent advances in research gained by immunohistochemical, molecular biological, and cytogenetic methods are included, as far as they are applicable for daily diagnostic work. The chapter on neoplasms, in particular, has been greatly expanded in accordance with the new WHO International Histological Classification of genital tract tumors, covering all pertinent differential diagnostic aspects. The chapter on malignant lymphomas and hematopoetic neoplasms involving the endometrium is a new contribution to this edition (F. D. , Ulm). We have revised the chapter on gestational diseases, incorpor- ing recent advances in the differential diagnosis of gestational trophoblastic tumors. New discoveries and experiences in correlating structure and function in infertility and in h- mone replacement therapy of peri- and postmenopausal patients are also included. Many new microphotographs have been added to illustrate the advances in tumor research and in immunohistochemical detection methods. We have updated the list of references including recent relevant publications. To the correspondents and consultants who have contributed valuable observations and suggestions, bringing thereby to our attention omissions in the second edition, we acknowledge our cordial thanks. We thank Dr. Wolfram Klapper, Director of the L- phom Register of the University of Kiel, for case material for making the micropho- graphic illustrations of lymphomas. The staff of Springer-Verlag has earned our gratitude for their skill in preparing this new edition.

The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology,tumor virology,and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in op- mizing clinical management and prognosis. A new chapter on immunohistochemistry has been added,which includes refined detection methods,e. g. ,the overexpression of INK4a p16 as a molecular marker in the early differential diagnosis of premalignant - sions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cel- lar and nuclear deregulation at the molecular level. All chapters have been revised to - clude the newest advances and relevant experiences in how to interpret and manage cervical disease; they are supported by the addition of 35 new microphotographic ill- trations. The tumor nomenclature is adapted to the latest edition of the WHO classi- cation; the morphology code of the international classification of diseases for oncology (ICD-O) has been added.We have also updated the list of references by adding recent relevant publications. Again,the staff of Springer-Verlag deserve our thanks for their patience and skill in preparing the manuscript and in reproducing the microphotographs. Heidelberg,February 2005 Gisela Dallenbach-Hellweg, Magnus von Knebel Doeberitz, and Marcus J. Trunk Heading2 Preface to the First Edition During the past decade our understanding of the histopathology of the cervix uteri has changed greatly.

Reevaluation of tumor classification, differential diagnosisand differential therapy based on modern knowledge. Revisionof all chapters to incorporate new facts based on recentdiscoveries.

Der Atlas gibt einen umfassenden Uberblick uber den diagnostischen Aussagewert der Phasenkontrastmikroskopie fur die gynakologische Sprechstundenzytologie am Frischpraparat. Nach einer Einfuhrung in die Anwendungsbereiche der gynakologischen Vitalzytologie verhelfen technische Erlauterungen zur prazisen Handhabung der Methode und des Phasenkontrastmikroskops. Der anschliessende Textteil vermittelt eine straff gegliederte Zusammenfassung der wesentlichen Erkennungsmerkmale der Einzelzellen und des Gesamtzellbildes unter physiologischer hormoneller Stimulation und deren endogen oder iatrogen ausgelosten Abweichungen, unter bakterieller Besiedelung und im Laufe der Karzinogenese. Es folgen Beschreibungen von Nebenbefunden, sekundaren Zellveranderungen und Artefakten. In gleicher Reihenfolge sind im angeschlossenen Bildteil 143 meist grossformatige Mikroskopaufnahmen typischer Zellen und Zellverbande dargestellt. This atlas provides a comprehensive overview of the diagnostic value of phase-contrast microscopy in the cytologic examination of smears taken in the gynecological practice. The range of applications and methods are fully described.The text summarizes distinguishing factors of single cell and the overall clinical picture. The atlas section contains large-format photomicrographs of cells and cell clusters.

Although the purpose and scope of this monograph remain unchanged, I have been obliged to revise and rewrite many sections to keep pace with the recent growth in knowledge of endometrial pathology and physiology. New knowledge emanates from every quarter, engendered by improved meth­ ods of study in virtually every subspecialty, by exemplary cooperation between disciplines, and especially by the exchange of ideas internationally. On the other hand, the catalogue of diseases is everchanging. Some, once common, become rare or even disappear. Others suddenly appear, unique and previously unknown. Increased longevity, modern ways of living and new methods of treat­ ment have modified or augmented the clinical and diagnostic problems confront­ ing us. Accordingly, therapy with hormones and intrauterine contraception re­ ceive special attention, commensurate with the importance afforded them today. Under the precept "nil nocere," the almost unlimited uses for these agents warrant that their effects be carefully monitored by precise morphological stud­ ies, a prerequisite that succeeds only when clinician and pathologist cooperate closely. The sections on procedures for obtaining endometrial tissue, on steroid receptors, on functional disturbances, and on spontaneous abortion have been changed or expanded to incorporate new facts from recent discoveries that now appear significant. Only time, however, will prove their true value. Much of historical interest in the text has been left intact, for "who wants to read into the future, must consult the past" (Andre Malraux).