Giuliano Mariani – författare

Nuclear Oncology: Pathophysiology and Clinical Applications is a comprehensive textbook covering the increasing role of radionuclide-based technologies in the management of oncologic patients, with disease-oriented chapters giving a detailed overview of current indications and developments. Topics covered include instrumentation, physics, radiobiology, radioguided surgery, and radionuclide therapy, which is discussed with useful separate topics describing the importance of organ function assessment after cancer therapies in the heart, lung, kidney and the gastro-intestinal tract. Additionally, significant aspects of cancer biology and molecular imaging are discussed, as well as appropriate tracers for both single- and positron-emitting radionuclides. Individual chapters in the book focus on the most common cancers occurring in adults and children, detailing radionuclide procedures within an integrated framework identifying the information required for effective treatment of specific tumors. These clinical chapters provide a description of the epidemiology, etiology, histologic and pathophysiologic classification, prognosis, treatment, and most common outcome for each type of cancer.

With contributions from a group of internationally-distinguished practitioners, Nuclear Oncology: Pathophysiology and Clinical Applications serves as a valuable compendium of knowledge for nuclear medicine physicians and radiologists and other clinicians involved in the care and management of cancer patients.

The main goal of the second edition of this book is to update the content on the rapidly growing field of lymphoscintigraphy, a radionuclide-based imaging procedure that provides information on the functional status of the lymphatic system. Although the technique was originally introduced to identify the cause of peripheral edema (i.e., blockage of the venous or lymphatic circulation), more recent and widespread applications include radioguided biopsy of the sentinel lymph node in patients with solid cancers. This procedure is crucial for the adequate planning of oncologic surgery in a growing number of cancers, most notably breast cancer, cutaneous melanoma, head and neck cancers, penile cancer, and cervical cancer.

The book focuses on the latest advances in lymphoscintigraphy techniques, including both novel tracers recently approved for clinical use (especially in the field of sentinel lymph node mapping) and the expanding role of hybrid imaging with SPECT/CT – and in sentinel node detection using hybrid tracers (radiolabeled and fluorescent) for dual-signature guidance. Each chapter addresses the clinical application of lymphoscintigraphy in different anatomic areas or disease conditions. After an introductory section concerning the pathophysiology of the specific site/disease, the clinical relevance and impact of lymphoscintigraphy is demonstrated by a collection of richly illustrated teaching cases describing the lymphoscintigraphic patterns most commonly observed, as well as anatomic variants and technical pitfalls. Emphasis is placed on tomographic multimodality imaging.

The book gathers contributions by experts in nuclear oncology, who have revised their chapters by updating the didactic material and adding clinical cases. Regarding sentinel lymph node biopsy in particular, a major distinction of this text is the incorporation of the staging guidelines of the American Joint Committee on Cancer (8th edition) into the didactic material.

The aim of the second edition of this book is to update the first (published in 2013) by reflecting the changes in this rapidly evolving field. Particular attention is paid to the latest advances in the radionuclide imaging of infection and inflammation, including the expanding role of hybrid imaging with [18F]FDG PET/CT SPECT/CT, without neglecting new radiotracers proposed for the imaging of infection/inflammation.

Written by respected experts in the field, the book will be an invaluable tool for residents in nuclear medicine, as well as for other specialists.

This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo.

Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of updated cases that define and expand the didactic material in the clinical application chapters. Thoroughly updated and revised, the third edition incorporates new clinical evidence validating the use of radionuclides for diagnosis and therapy in oncology, new radiotracers, and the growing integration of imaging modalities into different types of hybrid imaging.

With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Third Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.

This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo.       

Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of cases that define and expand the didactic material in the  clinical application chapters. Thoroughly updated and revised, the second edition incorporates advances in imaging and therapy and features the  current staging guidelines of the American Joint Committee on Cancer. 

With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Second Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.

Building on the traditional concept of nuclear medicine, this textbook presents cutting-edge concepts of hybrid imaging and discusses the close interactions between nuclear medicine and other clinical specialties, in order to achieve the best possible outcomes for patients.

Today the diagnostic applications of nuclear medicine are no longer stand-alone procedures, separate from other diagnostic imaging modalities. This is especially true for hybrid imaging guided interventional radiology or surgical procedures. Accordingly, today’s nuclear medicine specialists are actually specialists in multimodality imaging (in addition to their expertise in the diagnostic and therapeutic uses of radionuclides).

PROVV

Questo libro nasce da una sentita esigenza didattica relativa in primo luogo all’insegnamento della Medicina Nucleare, che è materia di almeno quattro corsi integrati ("Radiofarmaci", "Strumentazione in Medicina Nucleare", "Tecniche di Medicina Nucleare", e "Terapia con Tecniche di Medicina Nucleare") distribuiti nell’arco di due anni del Corso di Laurea in "Tecniche di Radiologia Medica per Immagini e Radioterapia" (TSRM). Infatti, non esiste un testo Italiano dedicato specificamente a questo Corso di Laurea, e il libro rappresenterebbe quindi un riferimento comune per tutti gli studenti in ogni Ateneo italiano sede del Corso di Laurea. Inoltre, il libro è concepito anche come fonte di aggiornamento e di adeguamento della cultura professionale dei TSRM già laureati alla continua evoluzione di tecniche e tipiche della Medicina Nucleare (incluso l’imaging "ibrido" in generale) in questo periodo di importante trasformazione della disciplina. Infine, anche gli Specializzandi in Medicina Nucleare (come pure quelli in Radiodiagnostica, in Radioterapia, e in Oncologia Medica) possono trovare in questo libro utili fonti di formazione e di aggiornamento su differenti aspetti di pratica della Medicina Nucleare e sulla interazione di questa Specialità con altre Specialità. Il libro è articolato in capitoli che seguono una sequenza logica orientata alla comprensione (secondo parametri di chiarezza e di applicabilità) dei fenomeni fisici alla base della Medicina Nucleare, del funzionamento degli strumenti di misura della radioattività e degli strumenti di formazione dell’immagine medico-nucleare, della produzione e controllo di qualità di radiofarmaci specifici per ogni applicazione, degli eventi biologici e fisiopatologici che determinano la biodistribuzione in vivo di tali radiofarmaci, delle indicazioni cliniche alle varie applicazioni medico-nucleari (sia diagnostiche che terapeutiche), delle tecniche di esecuzione, acquisizione edelaborazione delle varie applicazioni diagnostiche, e infine della normativa e della pratica più attuali in tema di radioprotezione del paziente, degli operatori, e dell’ambiente.