Gurmit Singh – författare

This book is intended for candidates preparing for postgraduate medical examinations such as the MRCP, helping them to identify the features evident in the radiological image shown and to formulate a differential diagnosis and know aspects of the necessary management.

Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer. Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies. The book provides an overview of molecular factors that offer targets and avenues for therapeutic strategies.

Most of the morbidity and mortality associated with malignant disease arise from metastases rather than primary tumors. Patients with advanced breast or prostate cancers usually develop bone metastases; at the time of death the skeleton often bears the bulk of their tumor burden. This book covers the latest advances in understanding the molecular mechanisms underlying the pathophysiology of bone metastasis that are now driving the development of new therapeutic strategies, as exemplified by the successful use of bisphosphonates for metastatic bone disease. It covers everything from growth factors and proteases to the role of photodynamic therapy to the use of hormones.

A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.

For the MRCP Part 2 exam, candidates need to be able to interpret radiological images of commonly encountered conditions. They also increasingly need to be able to answer other questions about the condition shown in the image, for example treatment and prognosis. This book has been designed to meet that need.It is divided into five sections: chest, abdomen, nervous system, cardiovascular system and musculoskeletal system. Each condition described is illustrated by one or two high quality radiological images and then provides a concise but holistic view of the condition, with all the important aspects of disease that the candidate will be expected to know. This information is supplemented by a short series of example exam questions.

This volume will introduce new terminology to the field of oncology, subdividing it into oncokinetics—the mechanics of the tumor cells as they arise and spread throughout the body—and oncodynamics—the impact of abnormal cues generated by tumors on the physiological functioning of the body. The volume will outline the importance of oncodynamics from both a cancer patient’s and a caregiver’s perspectives, stressing its significant impact on cancer patient functionality and the opportunity that cancer researchers will have to develop cross-disciplinary interactions and predict potential consequences of tumors and/or treatment.

This volume will introduce new terminology to the field of oncology, subdividing it into oncokinetics—the mechanics of the tumor cells as they arise and spread throughout the body—and oncodynamics—the impact of abnormal cues generated by tumors on the physiological functioning of the body.