H. Draper - Böcker

Advances in Nutritional Research was conceived by the Public and Professional Information Committee of the American Institute of Nutrition as a service to the membership of the Institute and to others engaged in research and teaching in the nutritional sciences. This publication, which will consist of a series of annual volumes, is in­ tended to serve primarily as a source of authoritative information on the status of research on topics of active current investigation. In addition, it will contain reviews on subjects of research that have been characterized by progressive, if unspectacular, developments over a period of years. The coverage will extend to basic research in human, animal, and microbial nutrition, nutritional biochemis­ try, clinical nutrition, nutritional toxicology and pathology, and related specialties. The editors hope that this series will assist investigators to keep abreast of new developments in the broad field of nutritional research. It should be 'of particular value to graduate students and to investigators who wish to acquire a grasp of the current state of knowledge in fields other than their own. If the response of authors of the chapters in this first volume and the quality of their contributions are indicative, this hope will be realized. H. H. Draper Chairman, Board of Editors vii Contents Chapter 1 Role of Vitamin K in the Synthesis of Clotting Factors. . . 1 1. W. Suttie 1. Historical Background ..................................... .

This volume continues the theme established in Volume 1 of providing a con­ spectus of the current state of knowledge on topics of active nutritional re­ search. It is the aim of the editors, through this series, to assist investigators in keeping abreast of developments in fields other than their own and to provide a source of reference materials for use in graduate teaching. In addition, general reviews will be published occasionally on fields of less active current research interest which have not been reviewed recently elsewhere. The quality of the contributions to Volumes 1 and 2, and of the manuscripts scheduled for publication in future volumes, gives assurance that Advances in Nutritional Research will be an asset to those engaged in research and teaching in the broad field of the nutritional sciences. vii Contents Chapter 1. Regulation of Energy Metabolism in Ruminants ...... 1 Ransom Leland Baldwin and Nathan Elbert Smith 1. Introduction ............................................. .

Volume 5 of Advances in Nutritional Research reflects a strong current interest in the relationship between nutrition and disease. The impact of disease on nutritional status is described for hepatic encephalopathy and cancer and for several ailments of hospitalized children. The impact of nutrition on disease is illustrated using the examples of retinol in tumorigenesis, vitamins A and E in inflammatory lung disease, fatty acids in atherogenesis and obesity, and folate in megaloblastic anemia. The contents will be of particular interest to clinicians and to students of nutritional biochemistry. vii Contents Chapter 1. Nutritional Management of Hepatic Encephalopathy ... Robert H. Bower and Josef E. Fischer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Nature of Hepatic Encephalopathy. . . . . . . . . . . . . . . . . . . . . . . . 2 2.1. The Ammonia Concept . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2. The Amino Acid Neurotransmitter Concept. . . . . . . . . . . . . . . 3 3. Nutritional Support in Hepatic Insufficiency. . . . . . . . . . . . . . . . . . . . 6 3. 1. Therapeutic Implications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.2. Therapeutic Options. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 4. Experiments in Animals. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 5. Experience with Patients in Hepatic Encephalopathy . . . . . . . . . . . . . 7 5.1. Acute Hepatic Encephalopathy . . . . . . . . . . . . . . . . . . . . . . . . . 7 5.2. Chronic Hepatic Encephalopathy........................ 9 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Chapter2. Cellular Retinol-and Retinoic Acid-Binding Proteins... 13 Frank Chytil and David E. Ong 1 . Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . . . . . . . . 2. Cellular Retinol-and Retinoic Acid-Binding Proteins . . . . . . . . . . 13 . 2.1. Detection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 . . . . . . . . . . . . 2.2. Characteristics . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 . . . . . . . . . . . 3. Binding Proteins in Cultured Cells . . . . . . . . . . . . . . . . . . . . 19 . . . . . . . 4. Binding Proteins in Tumors. . . . . . . . . . . . . . . . . . . . . . . . 23 . . . . . . . . . 4.1. Binding Proteins in Experimental Tumors . . . . . . . . . . . . . 23 . . . 4.2. Binding Proteins in Human Tumors . . . . . . . . . . . . . . . . 23 . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 . . . . . . . . . . . . . . ix x Contents Chapter 3. Nutrition and 3-Methylindole-lnduced Lung Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 . . . . . . . . . . . . . .