Hans-Joachim Hübschmann – författare

An essential guide to the proven automated sample preparation processWhile the measurement step in sample preparation is automated, the sample handling step is manual and all too often open to risk and errors. The manual process is of concern for accessing data quality as well as producing limited reproducibility and comparability.Handbook of Automated Sample Preparation for CG-MS and LC-MS explores the advantages of implementing automated sample preparation during the handling phase for CG-MS and LC-MS. The author, a noted expert on the topic, includes information on the proven workflows that can be put in place for many routine and regulated analytical methods.This book offers a guide to automated workflows for both on-line and off-line sample preparation. This process has proven to deliver consistent and comparable data quality, increased sample amounts, and improved cost efficiency. In addition, the process follows Standard Operation Procedures that are essential for audited laboratories. This important book: Provides the information and tools needed for the implementation of instrumental sample preparation workflowsOffers proven and detailed examples that can be adapted in analytical laboratoriesShows how automated sample preparation can reduce cost per sample, increase sample amounts, and produce faster resultsIncludes illustrative examples from various fields such as chemistry to food safety and pharmaceuticalsWritten for personnel in analytical industry, pharmaceutical, and medical laboratories, Handbook of Automated Sample Preparation for CG-MS and LC-MS offers the much-needed tools for implementing the automated sample preparation for analytical laboratories.

Essential handbook for all analytical scientists and laboratories using GC-MS, covering both the fundamental and practical aspects of this analytical technique From essentials to applications, Handbook of GC-MS:Fundamentals and Applications is a comprehensive reference and training compendium on the popular and evolving technique of GC-MS (gas chromatography/mass spectrometry), guiding readers through the most used sample preparation methods for GC-MS and method development, with many practical indications supporting the design of optimized analyses, and providing practical approaches to data processing, compound identification, and quantification. The text details both a solid background and principles of operation, as well as a broad range of current real-life examples taken from laboratories in environmental, food, pharmaceutical, and forensic analysis. It also features a glossary of more than 300 terms, and a comprehensive substance index that facilitates finding a specific application. This timely Fourth Edition covers the latest developments in automated sample preparation techniques and instrumentation, also with the focus on Green Analytical Chemistry. This comprehensive handbook presents GC-MS applications in various fields, with coverage of the well-known QuEChERS pesticide extraction, solid phase extraction and solid phase microextraction, static and dynamic headspace analysis, liquid/liquid extraction, outgassing, and thermal desorption, including pyrolysis. Single and triple quadrupole, Orbitrap, time-of-flight, magnetic sector, ion mobility and isotope ratio MS are discussed with their advantages and limitations. Sample topics covered in Handbook of GC-MS: Fundamentals and Applications include: Sample inlet systems for hot needle, liquid band injection with large volume and LC-GC application, carrier gas saving, choice of columns, septa and injection port linersOptimization of the GC method with carrier gas flow, effect of oven temperature ramp rates, fast GC, and multi-dimensional gas chromatographyIonization processes, electron and chemical ionization, resolution power in mass spectrometry, reading and interpreting mass spectraExtraction of mass spectra, manual spectrum subtraction, deconvolution of mass spectra, retention index, and library search of mass spectraTypical mass spectra of common analyte groups like pesticides, persistent organic pollutants, drugs; explosives; and of frequently occurring impuritiesQuantification using external and internal standards and standard addition methods. Determination of the limits of detection and quantitation.Applications covering food, water, flavor and fragrance, metabolomics, forensic and material analysisThe Handbook of GC-MS: Fundamentals and Applications is an essential reference for the daily GC-MS practice and application of new methods. It serves as an excellent introduction for newcomers as well as an educational resource about this analytical technique. Analytical chemists, chromatographers, environmental chemists, food chemists, and pharmaceutical chemists will find it of high practical use.