Hardeep Singh Tuli – författare

The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.

This book explores potential cellular drug targets for cancer therapy. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment.

This book explores potential cellular drug targets for cancer therapy. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment.

The applications of nanoparticulate drug delivery have gained significant attention in cancer diagnosis and treatment. Owing to their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine spans multitudes of drug-delivery systems that include high tumor-targeting ability, sensitivity toward tumor microenvironments, and improved efficacy. Various nanocarriers have been developed and approved for anti-tumor drug targeting. These nanocarriers, such as liposomes, micelles, nanotubes, dendrimers, and peptides, offer several advantages including high selectivity, multifunctionality, specificity, biocompatibility, and precise control of drug release. This book provides complete information about each aspect of nanomaterials and nanotherapeutics, including synthesis, analysis, disease diagnosis, mechanistic insight, targeted drug delivery, and clinical implications in a concise and informative way. It presents simple and reader-friendly representations of the mechanisms of action of nanomaterials on cellular targets and highlights the challenges in targeted drug delivery with ongoing chemotherapeutic drugs.

Humankind has used a variety of spices to flavor food for centuries. However, the chemistry and potential health benefits of these herbs have become clearer only rather recently. Numerous studies performed during the past decades have revealed several advantageous properties of bioactive constituents of various spices, including their anticancer effects. This edited collection summarizes diverse types of anticancer activities of compounds derived from some well-known spices, describing the anticancer mechanisms behind their action and highlighting molecular targets and cellular signaling pathways. It acquaints the reader with the potential anticancer activities of agents contained in laurel, oregano, thyme, rosemary, basil, dill, parsley, and several other common spices. These molecular entities could probably be considered as lead structures for further design of more efficient anticancer drugs in the future.

Gut microbiota plays a crucial role in preventing cancer by influencing the immune system, regulating inflammation, and producing beneficial metabolites. This book is a comprehensive guide to understanding the role of gut microbiota in human health. It presents the latest research on gut microbiota, from the characterization of different microbial species to their functions in food conversion and cancer prevention. It sheds light on the diverse composition of gut microbiota, identified through DNA sequencing technology, and how it is influenced by various factors such as diet, genetics, and lifestyle. It highlights promising research on how gut microbiota can be manipulated to prevent health disorders. It is a must-read for anyone interested in understanding the complex and dynamic relationship between gut microbiota and human health.

This book offers a comprehensive exploration of how biopolymers—natural and bioengineered macromolecules—are revolutionizing wound care by mimicking the extracellular matrix, modulating immune responses, and enabling targeted delivery of therapeutic agents. Drawing on insights from leading experts, it examines key materials such as chitosan, alginate, collagen, and hyaluronic acid, highlighting their roles in advanced wound dressings, bioactive scaffolds, and drug delivery systems. Readers will gain a deep understanding of the biological mechanisms behind impaired healing, the biomimetic properties of biopolymers, and the cutting-edge technologies bridging laboratory research with clinical application. Designed as both an inspiring guide and a vital reference, this book is valuable for all readers who are interested in understanding wound management.

This edited book offers a comprehensive exploration of urological cancers, focusing on the pathophysiology and the promising role of phytochemicals in therapeutic interventions. It provides an in-depth understanding of the molecular characterization, risk factors, and progression of these cancers, alongside cutting-edge diagnostic methods.The chapters explore key topics such as the tumor microenvironment, recent advances in detection, and the mechanistic insights of anticancer phytochemicals. The book bridges ancient remedies with contemporary pharmacological developments, emphasizing alternative therapies and the challenges in drug discovery. It also delves into the role of long non-coding RNA biology, targeted nanoformulations, and the current state of clinical trials, offering a holistic view of the field.This volume is an invaluable resource for researchers, clinical oncologists, and students in the field of urological cancer biology. It offers a concise yet comprehensive guide to the latest advancements and challenges in the field, making it an essential read for those involved in precision medicine and drug development.

This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.