Heinz Redl – författare

This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells.

These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks.

The first Wiggers-Bernard Conference on shock, sepsis and organ failure, named after two outstanding scientists in shock research and experimental medicine, took an interdisciplinary approach to addressing three questions: whether multi-organ failure is a sequence of organ failures or a systematic disease; whether cellular events in trauma and sepsis are due to suppression, activation or both; and whether LPS or sepsis are necessary as mediators of organ failure. The topics discussed included humoral and cellular activation mechanisms, immuno-suppression, metabolic responses, and the source and action of endotoxin (including the release of cytokines, oxygen radicals and proteinases).

The second Wiggers Bernard conference took an interdisciplinary approach and addressed three topics with a view to gaining increased understanding of the development of the multi-organ failure syndrome. These were, gut as a source of organ failure; metabolic aspects of the liver in sepsis; and endothelium as a target in sepsis. Eighteen contributors addressed these questions from a number of directions, including operational mechanisms, metabolic response, source and action of endotoxin and endotoxin-derived mediators. This book of proceedings on internal medicine, infectious diseases and emergency medicine is intended for the use of specialists and clinicians in these fields as well as for anaesthetists and surgeons.

The Third Wiggers Bemard Conference took an interdisciplinary approach to examining the role of cytokines in the development of sepsis and multiple organ failure. Sixteen intemational experts examine the role of cytokines in Gram-positive and Gram-negative bacteremia and inflammatory processes such as lung inflammation. The contributions explore all aspects of two growth factors, interleukin I and interieukin VI, as far as these molecules trigger the pathological process. The intense discussions which followed each talk are also printed in the volume.

This first volume in the series Update and Future Trends in Fibrin Sealing presents various subjects in the field of wound healing on both a theoretical and clinical basis. Fibrin sealant plays an important role in the first stages of wound healing. Among the issues discussed is the relationship between biomaterials and other substances.

Die pathophysiologischen Veranderungen nach einer Lungenkontusion, die lokal in der Lunge selbst, aber auch systemisch, d.h. im gesamten Korper ablaufen, sind deshalb von besonderem Interesse, da die Lungenkontusion die Bedrohlichkeit eines Verletzungsmusters quoad vitam immer verstarkt, die Komplikationsdichte vermehrt und fur eine besondere Vulnerabilitat sorgt. Diese Arbeit bietet eine Darstellung der pathophysiologischen Grundmechanismen der Lungenkontusion. Eine ausfuhrliche historische Aufarbeitung der Lungenkontusionsforschung und eine umfassende Darstellung aller bekannten experimentellen Modelle zur Lungenkontusion erganzen die Ergebnisse.

At the Sixth Wiggers Bernard Conference, a group of scientists from various fields discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. This meeting was dedicated to the presentation and discussion of positive and negative findings related to the use of NOS inhibitors, the issue of specific and non-specific inhibitors and the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field. With appropriate dosing and timing the use of NOS inhibitors seems to be beneficial at least in severe sepsis situations, but some inhibitors and overdosing can be potentially dangerous.

At the Sixth Wiggers Bernard Conference, a group of scientists from various fields discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. This meeting was dedicated to the presentation and discussion of positive and negative findings related to the use of NOS inhibitors, the issue of specific and non-specific inhibitors and the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field. With appropriate dosing and timing the use of NOS inhibitors seems to be beneficial at least in severe sepsis situations, but some inhibitors and overdosing can be potentially dangerous.

A report on new findings involving the brain in traumatic and septic shock, and after brain injury. Adopting an experimental and clinical approach to treatment, the book presents specific results obtained from the encephalogram and from histopathological study with regard to the immunohistochemistry of toxic lipid peroxidant products. It also includes the latest results of clinical and experimental pathophysiology in inflammatory processes after traumatic brain injury and the therapeutic effects of hypertonic fluid therapy.

In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.