Henry J. Kaminski - Böcker

Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment.  Mirroring the first book, this two-volume edition is divided into two parts.  Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders.  Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes.  Neuromuscular Disorders in Clinical Practice, Second Edition is intended to serve as a comprehensive text for both novice and experienced practitioners.  General neurologists as well as specialists in neuromuscular medicine andtrainees in neuromuscular medicine, clinical neurophysiology and electromyography should find this book inclusive, comprehensive, practical and highly clinically focused.  Additionally, specialists in physical medicine and rehabilitation, rheumatology, neurosurgery, and orthopedics will find the book of great value in their practice.

Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment.

Basic and clinical investigators have contributed reports to this volume in which they explore new findings in myasthenia gravis and related diseases, exploring topics in basic science, translational research, and clinical science, including advances in therapies and treatment strategies. Topics covered include the following: structure and function of the neuromuscular junction; communication between nerve and muscle; structure and function of the acetylcholine receptor; neuromuscular junction pathology; autoimmunity and signaling; immunology of autoimmune disorders involving the neuron and presynaptic nerve terminal; autoimmune pathogenesis of myasthenia gravis; clinical treatments including thymectomy; myasthenia gravis due to muscle-specific kinase antibodies.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Advances in the study and understanding of myasthenia gravis have led to the need for the publication of this important new edition. The goal of Myasthenia Gravis and Related Disorders, Second Edition is identical to the first -- to provide the clinician and the scientist with a common resource for understanding this complex disorder. This new edition begins with discussions of neuromuscular junction structure and function and follows with updated chapters covering a wide range of topics, such as the acetylcholine receptor, clinical presentation, diagnostic evaluation, and treatment. Importantly, new supplemental chapters have been added; these discuss rigorous clinical assessments of patients for research trials and the epidemiology and genetics of myasthenia gravis. The discussion of the most challenging aspects of myasthenia gravis, its impact on patients’ psychological make-up, has been expanded as well. Myasthenia Gravis and Related Disorders, Second Edition retains the “personal approach” of the authors regarding treatment and is a valuable resource for meeting the many and varied needs of patients with myasthenia gravis.

Advances in the study and understanding of myasthenia gravis have led to the need for the publication of this important new edition. The goal of Myasthenia Gravis and Related Disorders, Second Edition is identical to the first -- to provide the clinician and the scientist with a common resource for understanding this complex disorder. This new edition begins with discussions of neuromuscular junction structure and function and follows with updated chapters covering a wide range of topics, such as the acetylcholine receptor, clinical presentation, diagnostic evaluation, and treatment. Importantly, new supplemental chapters have been added; these discuss rigorous clinical assessments of patients for research trials and the epidemiology and genetics of myasthenia gravis. The discussion of the most challenging aspects of myasthenia gravis, its impact on patients’ psychological make-up, has been expanded as well. Myasthenia Gravis and Related Disorders, Second Edition retains the “personal approach” of the authors regarding treatment and is a valuable resource for meeting the many and varied needs of patients with myasthenia gravis.

The overarching goal of this new edition is identical to the first and second -- to provide the clinician and the scientist with a common resource for understanding the profound achievements in the clinical, translational, and basic sciences of neuromuscular transmission disorders.

Myasthenia gravis treatment has seen remarkable progress, with FDA approval of a first-in-class drug targeting autoimmunity. Additionally, more than 20 therapies are currently in development, ranging from pre-clinical stages to Phase 3 trials.This new and expanded edition explores these new therapies and other new developments in MG. The book retains its comprehensive review of MG, covering clinical presentation, laboratory and electrophysiological diagnosis, and treatment. These chapters offer neurologists and neuromuscular experts the latest insights into state-of-the-art patient care. The text then delves into focused chapters on epidemiology, genetics, and cancer-associated MG, broadening the appeal to scientists exploring the autoimmune drivers linked to tumors and the genetic underpinnings of MG pathophysiology.Chapters on related disorders are included due to their clinical and pathological similarities to MG. These sections provide valuable insights into antibody-mediated diseases that mirror MG in their clinical manifestations. Finally, the book concludes with chapters on clinical trial design, biomarker development, and the psychological impact of MG on patients. These chapters are essential not only for academic clinical investigators but also for professionals in the pharmaceutical industry, from research scientists to clinical trial developers.Myasthenia Gravis and Related Disorders, 4th Edition is the definitive resource for researchers and clinicians in this rapidly evolving field.