Hisato Kondoh – författare

Sox2: Biology and Role in Development and Disease offers a thorough discussion of the important role of Sox2 in cellular and developmental processes, aimed at facilitating greater understanding of how Sox2 functions across different disciplines. The book discusses the basic biology of Sox2 to help establish the critical foundational knowledge necessary for deeper molecular and functional analysis. The book also provides insight into how the Sox2 transcription factor plays a key role in pluripotency induction, maintenance, and development.

Helpful as a tool to organize new research projects, the book assists with preparing lessons, seminars, and thesis or research papers, thereby circumventing the need to spend hours searching through journal databases. A single source for the basic biology of Sox2, Sox2: Biology and Its Role in Development and Disease provides information on networks, gene regulation, and regulatory function in a number of cell types and tissues types.

This book provides a comprehensive overview of the molecular basis of developmental and stem cell regulation. It revisits some of the classical models of developmental biology and puts them in context with the findings of modern stem cell research and developmental biology. 

Biomedical research is embarking on a new era due to new tools, which are exemplified by stem cell technologies, single-cell transcriptome analysis, and live imaging at a single-cell resolution. Publications based on cutting-edge technologies do often not provide the readers with deep biological backgrounds. This causes the risk that precious data are reduced to highly specific descriptions without sufficient biological contexts.

Contemporary developmental biology on the other hand as written in many textbooks, is to a significant extent based on conceptions backdated many decades ago, and is not necessarily supported by recent findings. Yet, the prevailing classical notions tend to mislead modern biomedical researches.

This book not only presents current models for developmental processes but also reinterprets and re-evaluates classic observations, thus linking classical and modern worlds of developmental biology. Spanning from molecular mechanisms to highly embryological matters it provides a bridge between these different disciplines.

Written for advanced students of developmental and stem cell biology, researchers and teaching scholars, this book provides a new road map to modern developmental biology and stem cell biology.