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3 produkter
3 produkter
Del 217 - Advances in Anatomy, Embryology and Cell Biology
Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
Häftad, Engelska, 2015
1 104 kr
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This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
1 652 kr
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70 years after the discovery of secretory neurons, internationally leading experts gathered to discuss the latest developments in neuropeptide research and endocrinology, concentrating on the molecular, cellular, supracellular and systemic aspects. A variety of neuropeptidergic systems are considered under comparative and evolutionary aspects.
Functional Morphology of Neuroendocrine Systems
Evolutionary and Environmental Aspects
Häftad, Engelska, 2011
1 066 kr
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An international symposium titled "Functional Morphology of Neuroendocrine Systems: Evolutionary and Environmental Aspects" was held on the occasion of the 60th birthday of Professor Andreas Oksche, head of the Department of Anatomy and Cytobiology, Justus Liebig University, Giessen, FRG. This volume containing the texts of the plenary lectures and the abstracts of poster contributions presented at the symposium on July 30-August 1, 1986 in Giessen, reflects the rapid expansion of the field of neuroendocrinology. New insights into the interactions between neurons acting as endocrine cells and conventional neurons have been gained by the use of newly developed neurobiological techniques (e. g. , immuno- cytochemistry, tracing of neuronal connections by means of anterograde and retrograde axonal transport of identified molec- ules, electrophysiological recordings in vivo and in vitro). The findings of the past few years have extended the fundamental concept of neurosecretion introduced by Ernst and Berta Scharrer in close cooperation with Wolfgang Bargmann.An important landmark was the discovery that neurons containing classical neurosecretory products not only project to neurohemal release organs but also establish hypothalamic and extrahypothalamic neuro-neuronal contacts. In some of these neurons monoamine transmitters are known to co-exist with opioid and other neuro- peptides. Different types of transmitters may even be co-localized in the same dense core vesicles. The use of extremely sensitive techniques which allow the detection of minute quantities of messenger substances has provided evidence that several of these substances have been well preserved in the course of evolution.