Howard Friel – författare

A Paradigm Shift to Prevent and Treat Alzheimer's Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer's disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years.

These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth.

This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model.

A Paradigm Shift to Prevent and Treat Alzheimer's Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers.

Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer's disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer's disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols

A compelling exposé of the highly problematic scholarship of Bjørn Lomborg, the world’s leading global warming skepticIn this major assessment of leading climate-change skeptic Bjørn Lomborg, Howard Friel meticulously deconstructs the Danish statistician’s claim that global warming is “no catastrophe” by exposing the systematic misrepresentations and partial accounting that are at the core of climate skepticism. His detailed analysis serves not only as a guide to reading the global warming skeptics, but also as a model for assessing the state of climate science. With attention to the complexities of climate-related phenomena across a range of areas—from Arctic sea ice to the Antarctic ice sheet—The Lomborg Deception also offers readers an enlightening review of some of today’s most urgent climate concerns.Friel’s book is the first to respond directly to Lomborg’s controversial research as published in The Skeptical Environmentalist (2001) and Cool It: The Skeptical Environmentalist’s Guide to Global Warming (2007). His close reading of Lomborg’s textual claims and supporting footnotes reveals a lengthy list of findings that will rock climate skeptics and their allies in the government and news media, demonstrating that the published peer-reviewed climate science, as assessed mainly by the U.N.’s Intergovernmental Panel on Climate Change, has had it mostly right—even if somewhat conservatively right—all along. Friel’s able defense of Al Gore’s An Inconvenient Truth against Lomborg’s repeated attacks is by itself worth an attentive reading.