H.R. Kaback – författare

In recent years it has become evident that transport processes across membranes play a crucial role in many metabolic systems. The activities of these transport processes often determine the physiology of the organisms.This book presents a state of the art review on the analysis of a wide variety of transport systems from bacteria and eukaryotic cells. A selection has been made of those systems that have been studied at the molecular level with special emphasis paid to the energetic and other biophysical properties. The different classes of transport systems are presented in the following: primary transport, secondary transport, phosphotransferase systems, channels and porines and macromolecular transport. Within each class of transporters several systems are presented by the leading experts in the field, which has resulted in a very broad overview of transport processes in biological cells. In this way the differences in the mechanisms used for translocation become evident while on the other hand features common to the different transport systems are revealed.

This book is a compilation of formal presentations made during a three-day invitational conference at Battelle Research Center in Seattle, Washington. The purpose of organizing and publishing the proceedings of the conference is to provide a comprehensive survey of present knowledge on the determinants of membrane structure, the molec­ ular specificity of membrane function, and the dynamic properties of membranes. Each presentation was followed by discussions which, be­ cause of their informal and spontaneous character, have not been in­ cluded in this publication. Molecular studies of biological membrane phenomena have progressed over the past decade to the point where it is now realistic to expect future resolution of the physico-chemical processes or forces governing the organization, function, and dynamic properties of membranes. Drs. Radda, Kaback, and Schwyzer, each presenting a different approach to the biochemical and biophysical study of membranes, devoted four to six weeks as Battelle Visiting Fellows to developing the format and the roster of participants of the conference. The scientific "cluster" concept for planning the conference is reflected in the breadth of topics presented in this publication.