Hywel Williams - Böcker

Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion.See what’s new in the Fourth Edition: Fully updates and expands the contents Coverage of agonists and antagonists of neuro-transmitters Information on the design of stable peptide-like drugs The human genome and its impact on drug discovery and development Advances in therapy and pharmacokinetics Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.

Through his foreign conquests and internal reforms, Charlemagne is a defining figure of both Western Europe and the Middle Ages. Crowned king of the Franks in 768, he expanded their kingdoms into an empire that incorporated much of western and central Europe, recreating a single Christian imperium in the heartlands of the old Western Roman empire for the first time since the decline and fall of that polity in the late fifth century AD. After his imperial coronation Charlemagne was seen as a rival, in power and majesty, of the Byzantine Emperor in Constantinople. Charlemagne's empire, and the cultural golden age that is associated with it, encouraged the formation of a common European identity. In this magisterial new study, Hywel Williams explores every facet of the rule and legacy of one of the most remarkable rulers in European history. Emperor of the West is a major contribution to early medieval history, and is essential reading for anyone interested in the wider history of Europe.

The currents of History run deep and often unseen beneath the everyday ripple of events. But now and again the current rises to the surface, and the events of a single day shed an exceptional light on the meaning of the past. Such events are the subject of Days that Changed the World. Some of the 50 days described here mark the end of an era; others the start of something new. Many are the dates of bloody battles or murders; others of momentous decisions or breathtaking discoveries. All are remembered as powerful symbols of their time. Our story begins almost 2500 years ago on 28 September 480 before the Christian Era, when the Athenian navy destroyed the Persian invasion fleet in the Bay of Salamis. Had the Persians won we might never have heard the names of Plato, Aristotle or Alexander, nor recognize the word democracy. Charting 50 such defining moments, concluding with 11 September 2001 and the destruction of New York's Twin Towers, Days that Changed the World is a unique and fascinating way to portray the story of world history.These 50 history-making days include: The Battle of the Salamis; The Assassination of Julius Caesar; The Crucifixion of Jesus Christ; The Dedication of Constantinople; The Death of Muhammad; The Coronation of Charlemagne; The Death of Genghis Khan; The Fall of Constantinople; The Defeat of the Spanish Armada; The Defenestration of Prague; The Fall of the Bastille; The Battle of Waterloo; Parliament Passing the Emancipation Act; The Battle of Sedan; The Boxer Rebellion; The First Day of the Somme; The Japanese Attack on Pearl Harbour; The Bombing of Hiroshima; Martin Luther King's 'I have a Dream'; The Breaching of the Berlin Wall; Nelson Mandela's Release from Prison; Nine Eleven.

Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion.See what’s new in the Fourth Edition: Fully updates and expands the contents Coverage of agonists and antagonists of neuro-transmitters Information on the design of stable peptide-like drugs The human genome and its impact on drug discovery and development Advances in therapy and pharmacokinetics Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.

The currents of History run deep and often unseen beneath the everyday ripple of events. But now and again the current rises to the surface, and the events of a single day shed an exceptional light on the meaning of the past.Such events are the subject of Days that Changed the World. Some of the 50 days described here mark the end of an era; others the start of something new. Many are the dates of bloody battles or murders; others of momentous decisions or breathtaking discoveries. All are remembered as powerful symbols of their time.Our story begins almost 2500 years ago on 28 September 480 before the Christian Era, when the Athenian navy destroyed the Persian invasion fleet in the Bay of Salamis. Had the Persians won we might never have heard the names of Plato, Aristotle or Alexander, nor recognize the word democracy. Charting 50 such defining moments, concluding with Nelson Mandela's release from prison in 1990 and 9/11 a decade after, Days that Changed the World is a unique and fascinating way to portray the story of world history.Repackaged into a neat and striking format, with a brand new cover and an entirely narrative approach, it is bound to be anyone interested in History's favourite encyclopaedia.

'Let each know that for each the body, the mind and the soul have been freed to fulfil themselves.' These powerful words, spoken by Nelson Mandela in his inaugural address as the new president of South Africa, are taken from just one of the forty important and thought-provoking speeches in this collection. Ranging from 1945 to the present day, they provide an important insight into the modern world. Inspirational speeches by Winston Churchill, Mikhail Gorbachev, Martin Luther King, Barack Obama and many others are supplemented with biographies of each speaker, as well an exploration of their words' significance and an historical account of the consequences of their oratory. This is a history of the recent and contemporary world told through the speeches that shaped it.