Jacques Robert – författare

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Originally published in French as Le territoire européen: des racines aux enjeux globaux, this book reflects the enormous changes that Europe has seen in the past half century. In a period of immense upheaval, the continent has experienced increased integration, largely through the development of the European Union, heightened urbanization and a changing rural landscape, while economic and commercial activities have impressed their stamp on the whole scene.In this book, Jacques Robert deploys the experience amassed throughout his 35 years’ experience as adviser to European institutions in the field of territorial and regional development. The chapter on cities explains the emergence of the European urban hierarchy and the driving forces and inertia behind its evolution, while a following chapter looks at the changing role of rural areas. This material provides a historic overview of relevant policies and a discussion of future challenges. The third chapter discusses evolving paradigms of regional economic development and their impact on European regions. Next, there is a chapter on the historical roots and current processes within territorial integration. The book concludes with an examination of Europe’s place in the world at large, focussing particularly on globalization effects, climate change and new energy paradigms, which will present real challenges for decades to come.The book is unique in its combination of in-depth analysis of the evolution of European territorial policies and paradigms, but also in its geographically comprehensive approach integrating the experience of both Western and Eastern Europe. It will be of interest to academics and professionals within territorial development and spatial planning.

Originally published in French as Le territoire européen: des racines aux enjeux globaux, this book reflects the enormous changes that Europe has seen in the past half century. In a period of immense upheaval, the continent has experienced increased integration, largely through the development of the European Union, heightened urbanization and a changing rural landscape, while economic and commercial activities have impressed their stamp on the whole scene.In this book, Jacques Robert deploys the experience amassed throughout his 35 years’ experience as adviser to European institutions in the field of territorial and regional development. The chapter on cities explains the emergence of the European urban hierarchy and the driving forces and inertia behind its evolution, while a following chapter looks at the changing role of rural areas. This material provides a historic overview of relevant policies and a discussion of future challenges. The third chapter discusses evolving paradigms of regional economic development and their impact on European regions. Next, there is a chapter on the historical roots and current processes within territorial integration. The book concludes with an examination of Europe’s place in the world at large, focussing particularly on globalization effects, climate change and new energy paradigms, which will present real challenges for decades to come.The book is unique in its combination of in-depth analysis of the evolution of European territorial policies and paradigms, but also in its geographically comprehensive approach integrating the experience of both Western and Eastern Europe. It will be of interest to academics and professionals within territorial development and spatial planning.

Textbook of Cell Signalling in Cancer

This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis.This comprehensive reference text is based on the master’s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.