James MacKillop – författare

A comprehensive review of research examining intermediary mechanisms to understand the link between genetic variation and addiction liability.

Although there is scientific consensus that genetic factors play a substantial role in an individual''s vulnerability to drug or alcohol addiction, specific genetic variables linked to risk or resilience remain elusive. Understanding how genetic factors contribute to addiction may require focusing on intermediary mechanisms, or intermediate phenotypes, that connect genetic variation and risk for addiction. This book offers a comprehensive review of this mechanistic-centered approach and the most promising intermediate phenotypes identified in empirical research.

The contributors first consider the most established findings in the field, including variability in drug metabolism, brain electrophysiological profiles, and subjective reactions to direct drug effects; they go on to review highly promising areas such as expectancies, attentional processing, and behavioral economic variables; and finally, they investigate more exploratory approaches, including the differential susceptibility hypothesis and epigenetic modifications. Taken together, the chapters offer a macro-level testing of the hypothesis that these alternative, mechanistic phenotypes can advance the understanding of genetic influences on addiction. The book will be of interest to researchers and practitioners in a range of disciplines, including behavioral genetics, psychology, pharmacology, neuroscience, and sociology.

ContributorsJohn Acker, Steven R.H. Beach, Gene H. Brody, Angela D. Bryan, Megan J. Chenoweth, Danielle M. Dick, Eske D. Derks, Mary-Anne Enoch, Meg Gerrard, Frederick X. Gibbons, Thomas E. Gladwin, Mark S. Goldman, Marcus Heilig, Kent E. Hutchison, Hollis C. Karoly, Steven M. Kogan, Man Kit Lei, Susan Luczak, James MacKillop, Renee E. Magnan, Leah M. Mayo, Marcus R. Munafò, Daria Orlowska, Abraham A. Palmer, Danielle Pandika, Clarissa C. Parker, Robert A. Philibert, Lara A. Ray, Richard R. Reich, Ronald L. Simons, Courtney J. Stevens, Rachel E. Thayer, Rachel F. Tyndale, Tamara L. Wall, Reinout W. Wiers, Michael Windle, Harriet de Wit

“Much of our scientific effort in tackling the multifactorial nature of addiction has taken place within individual disciplines. However, it has become increasingly clear that the complexity of addiction requires an integrated approach. This Handbook is timely and exceptional, intelligently combining the latest research approaches and applying them to understanding and tackling the prodigious public health burden of addiction. An authoritative resource, it establishes a comprehensive framework that will guide the field in the next era of addiction research.”

John F. Kelly, PhD, President Elect, Society of Addiction Psychology, American Psychological Association; Associate Professor in Psychiatry, Harvard Medical School; Director, Addiction Recovery Management Service, Massachusetts General Hospital

The Wiley-Blackwell Handbook of Addiction Psychopharmacology presents a comprehensive guide to contemporary research approaches to the study of drug addiction in adults. With a focus on empirically relevant research methods and nuanced methodologies, it provides practical tools to enable strong psychopharmacological practices. Contributions from experts in diverse domains offer reviews of the most current experimental methodologies, make recommendations for “best practices,” and identify future directions for the field. Topics covered include core methods for assessing drug effects, distal and proximal determinants of drug use, and insights from cognitive neuroscience.

Compiled by a team of widely published researchers in substance addiction, The Wiley-Blackwell Handbook of Addiction Psychopharmacology is an authoritative, state-of-the-art collection of modern research approaches to the scientific study of drug addiction. Its multidisciplinary approach makes it a comprehensive and invaluable resource for all those in this field.

“Much of our scientific effort in tackling the multifactorial nature of addiction has taken place within individual disciplines. However, it has become increasingly clear that the complexity of addiction requires an integrated approach. This Handbook is timely and exceptional, intelligently combining the latest research approaches and applying them to understanding and tackling the prodigious public health burden of addiction. An authoritative resource, it establishes a comprehensive framework that will guide the field in the next era of addiction research.”

John F. Kelly, PhD, President Elect, Society of Addiction Psychology, American Psychological Association; Associate Professor in Psychiatry, Harvard Medical School; Director, Addiction Recovery Management Service, Massachusetts General Hospital

The Wiley-Blackwell Handbook of Addiction Psychopharmacology presents a comprehensive guide to contemporary research approaches to the study of drug addiction in adults. With a focus on empirically relevant research methods and nuanced methodologies, it provides practical tools to enable strong psychopharmacological practices. Contributions from experts in diverse domains offer reviews of the most current experimental methodologies, make recommendations for “best practices,” and identify future directions for the field. Topics covered include core methods for assessing drug effects, distal and proximal determinants of drug use, and insights from cognitive neuroscience.

Compiled by a team of widely published researchers in substance addiction, The Wiley-Blackwell Handbook of Addiction Psychopharmacology is an authoritative, state-of-the-art collection of modern research approaches to the scientific study of drug addiction. Its multidisciplinary approach makes it a comprehensive and invaluable resource for all those in this field.

Integrating Psychological and Pharmacological Treatments for Addictive Disorders distills the complex literature on addiction, offering a curated toolbox of integrated pharmacological and psychotherapeutic treatments in chapters authored by leading experts. Introductory chapters on the epidemiology, etiology, and fundamentals of addiction treatment provide a concise overview of the state of the field. Subsequent chapters then focus on the treatment of specific substance use disorders and on gambling disorder. Finally, a chapter on the treatment of addiction in primary care addresses the opportunities for clinical care in non-specialist outpatient settings. Physicians, psychologists, social workers, and other mental health professionals will come away from the book with an essential understanding of evidence-based practice in treating addiction and the scientific foundations of those approaches.

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Integrating Psychological and Pharmacological Treatments for Addictive Disorders distills the complex literature on addiction, offering a curated toolbox of integrated pharmacological and psychotherapeutic treatments in chapters authored by leading experts. Introductory chapters on the epidemiology, etiology, and fundamentals of addiction treatment provide a concise overview of the state of the field. Subsequent chapters then focus on the treatment of specific substance use disorders and on gambling disorder. Finally, a chapter on the treatment of addiction in primary care addresses the opportunities for clinical care in non-specialist outpatient settings. Physicians, psychologists, social workers, and other mental health professionals will come away from the book with an essential understanding of evidence-based practice in treating addiction and the scientific foundations of those approaches.

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