JF Holland – författare

This book gathers the educational lectures and the texts of the main presenta­ tions given at the 4th International Congress on Anticancer Chemotherapy which took place in February 1993 in Paris and was attended by 5 000 oncologists from all continents, physicians, students and nurses. This book aspires to give update of the most scientific and clinical aspects of modern oncology. It aims also at showing the prospects that are opened by the rapid progress of cancer biology. The editors are grateful to the authors whose scholarship de­ fines the quality of the book. Educational lectures The pathogenesis of human cancer metastasis I] Fidler Cancer is a collection of malignancies with each cancer of each organ consist­ ing of numerous subsets. This biologic and clinical heterogeneity is probably due to the different etiologies, origins, and selection pressures. Despite this heterogeneity, all malignant neoplasms have a uniform characteristic : the ability to invade host tissues and produce metastases. Clinical observations of cancer patients and studies with experimental rodent tumors have revealed that cer­ tain tumors produce metastasis to specific organs independent of vascular anat­ omy, rate of blood flow, and number of tumor cells delivered to each organ. The distribution and fate of hematogeneously disseminated, radiolabelled tumor cells in experimental rodent systems amply demonstrate that tumor cells reach the microvasculature of many organs.

This book gathers the educational lectures and the texts of the main presenta­ tions given at the 4th International Congress on Anticancer Chemotherapy which took place in February 1993 in Paris and was attended by 5 000 oncologists from all continents, physicians, students and nurses. This book aspires to give update of the most scientific and clinical aspects of modern oncology. It aims also at showing the prospects that are opened by the rapid progress of cancer biology. The editors are grateful to the authors whose scholarship de­ fines the quality of the book. Educational lectures The pathogenesis of human cancer metastasis I] Fidler Cancer is a collection of malignancies with each cancer of each organ consist­ ing of numerous subsets. This biologic and clinical heterogeneity is probably due to the different etiologies, origins, and selection pressures. Despite this heterogeneity, all malignant neoplasms have a uniform characteristic : the ability to invade host tissues and produce metastases. Clinical observations of cancer patients and studies with experimental rodent tumors have revealed that cer­ tain tumors produce metastasis to specific organs independent of vascular anat­ omy, rate of blood flow, and number of tumor cells delivered to each organ. The distribution and fate of hematogeneously disseminated, radiolabelled tumor cells in experimental rodent systems amply demonstrate that tumor cells reach the microvasculature of many organs.

The International Union Against Can- knowledge of what to do or how to do it; cer convened a Conference on the to identify the nature of, and reason for, Chemotherapy of Choriocarcinoma in the successful chemotherapeutic results in Baguio City, Philippines to focus atten- trophoblastic neoplasia (whether this be tion on the therapy of neoplasms of the specificity of drugs, the nature of the trophoblast. allogenic graft or characteristics of the Cures of cancer are of concern to every specific cells); and to determine the cau- man. The oldest therapy of cancer likely ses for failures (whether it be advanced consisted of herbs, potions and incanta- and long-standing disease, inappropriate tions. Cures may first have been achieved dosage regimens, or inherent resistance of in the murky annals of early civilization the tumors treated). If this first chemo- with local chemical cautery. The first therapeutically curable cancer can serve successes of surgery are lost in antiquity as a model for the chemotherapy of other and probably were amputations.Radia- autochthonous tumors, the therapeutic tion therapy was first used for cure in the principles may be useful for extrapolation early years of the 20th century. Curabil- to other tumors. Such unique maracteris- ityof the first cancer with drugs is a recent tics as the temnique of dosing and the phenomenon: choriocarcinoma in 1956.