Jialiang Li - Böcker

Using real data sets throughout, Survival Analysis in Medicine and Genetics introduces the latest methods for analyzing high-dimensional survival data. It provides thorough coverage of recent statistical developments in the medical and genetics fields. The text mainly addresses special concerns of the survival model. After covering the fundamentals, it discusses interval censoring, nonparametric and semiparametric hazard regression, multivariate survival data analysis, the sub-distribution method for competing risks data, the cure rate model, and Bayesian inference methods. The authors then focus on time-dependent diagnostic medicine and high-dimensional genetic data analysis. Many of the methods are illustrated with clinical examples.Emphasizing the applications of survival analysis techniques in genetics, this book presents a statistical framework for burgeoning research in this area and offers a set of established approaches for statistical analysis. It reveals a new way of looking at how predictors are associated with censored survival time and extracts novel statistical genetic methods for censored survival time outcome from the vast amount of research results in genomics.

Change point analysis is a crucial statistical technique for detecting structural breaks within datasets, applicable in diverse fields such as finance and weather forecasting. The authors of this book aim to consolidate recent advancements and broaden the scope beyond traditional time series applications to include biostatistics, longitudinal data analysis, high-dimensional data, and network analysis.The book introduces foundational concepts with practical data examples from literature, alongside discussions of related machine learning topics. Subsequent chapters focus on mathematical tools for single- and multiple-change point detection along with statistical inference issues, which provide rigorous proofs to enhance understanding but assume readers have foundational knowledge in graduate-level probability and statistics. The book also expands the discussion into threshold regression frameworks linked to subgroup identification in modern statistical learning and apply change point analysis to functional data and dynamic networks—areas not comprehensively covered elsewhere.Key Features:Comprehensive Coverage of Diverse Applications: This book expands the scope of change point analysis to include biostatistics, longitudinal data, high-dimensional data, and network analysis. This broad applicability makes it a valuable resource for researchers and students across various disciplinesIntegration of Theory and Practice: The book balances rigorous mathematical theory with practical applications by providing extensive computational examples using R. Each chapter features real-world data illustrations and discussions of relevant machine learning topics, ensuring that readers can see the relevance of theoretical concepts in applied settingsAccessibility for Students: The content is designed with graduate-level students in mind, providing clear explanations and structured guidance through complex mathematical tools. Rigorous proofs are included to facilitate understanding without overwhelming readers with overly advanced theories early onThe book incorporates computational results using R, showcasing various packages tailored for specific methods or problem domains while providing references for further exploration. By offering a selection of widely adopted methodologies relevant in scientific research as well as business contexts, this text aims to equip junior researchers with essential tools needed for their work in change point analysis.