Joachim Thiem – författare

Glycostructures play a pivotal and crucial role in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Within recent years tools have been developed to promote the understanding of their highly complex functions and the associated chemistry and chemical biology, however, many facts still remain undiscovered. These days the area is experiencing a “quantum jump”. Therefore the Editors in collaboration with six responsible Section Editors completely revised and updated the 1st edition to give up-to-date information on glycostructures, their chemistry and chemical biology, and present them in the form of a comprehensive and strictly systematic survey. The texts are furnished by more than 2500 figures, chemical structures and reaction schemes (including more than 12,000 individual chemical reactions), and more than 9,000 references.In concept and content this Major Reference Work received an essential improvement and expansion. Whereas chapter 1, 2, 3, 7, 8, and 9 are updated, expanded and rearranged versions of the 1st edition, many new subchapters are included in the chapters on monosaccharides, oligosaccharides and polysaccharides. The importance of the saccharide metabolism as well as the involvement of complex glycostructures in biologically and medically relevant processes are considered by addition of two large totally newly conceived chapters. Further, another novel chapter featuring key technologies and tools for functional glycobiology is incorporated. Responsible for this major update are the Section Editors who solicited a large number of highly reputed new authors to cover the changes in the content and to write the major supplements.

This book presents the state of the art in the synthesis very complex saccharide structures, written by leading scientist at the forefront of this rapidly growing field. Reflecting the particular significance in recent years of efficient and selective procedures employing enzymes for preparative purposes in the carbohydrate field, a major proportion of the articles focus on these biocatalytic methods. In addition, recent strategies for the construction of unusual carbohydrates structures employing novel and creative methodologies are highlighted. Further, particular emphasis is placed on very complex saccharide structures as well as on special solutions to problems that are particularly challenging.

The synthesis of very complex saccharide structures is one of the most challenging areas of modern glycoscience. This volume presents the state of the art of complex carbohydrate synthesis, written by leading scientists whose groups are making major contributions in the field. Reflecting the particular interest in inhibitors and modulators as well as in mimetics, an in-cepth treatment is given both of their selective syntheses and of their biological implications. In addition the concept of multivalent glycoconjugate recognition as well as supramolecular implications of amphiphilic carbohydrates are highlighted.

This book presents the state of the art in the synthesis very complex saccharide structures, written by leading scientists at the forefront of this rapidly growing field. Reflecting the particular significance in recent years of efficient and selective procedures employing enzymes for preparative purposes in the carbohydrate field, a major proportion of the articles focus on these biocatalytic methods. In addition, recent strategies for the construction of unusual carbohydrates structures employing novel and creative methodologies are highlighted. Further, particular emphasis is placed on very complex saccharide structures as well as on special solutions to problems that are particularly challenging.

Glycostructures play a highly diverse and crucial role in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them, but many facts still remain undiscovered. "All roads lead to carbohydrates ... we cannot do without them." (K.C. Nicolaou). Presently the field is experiencing a "quantum jump". Therefore the editors have drawn together in this three volume set plus an accompanying CD-ROM, the complete and up-to-date information on glycostructures, their chemistry and chemical biology, and present them in the form of a comprehensive and strictly systematic survey. The texts are furnished by 2.670 figures, chemical structures and reaction schemes (including more than 12.000 individual chemical reactions), and more than 9.000 references.

With contributions by numerous experts

With contributions by numerous experts