Joaquim M.S. Cabral - Böcker

Engineering Strategies for Regenerative Medicine considers how engineering strategies can be applied to accelerate advances in regenerative medicine. The book provides relevant and up-to-date content on key topics, including the interdisciplinary integration of different aspects of stem cell biology and technology, diverse technologies, and their applications. By providing massive amounts of data on each individual, recent scientific advances are rapidly accelerating medicine. Cellular, molecular and genetic parameters from biological samples combined with clinical information can now provide valuable data to scientists, clinicians and ultimately patients, leading to the development of precision medicine.

Equally noteworthy are the contributions of stem cell biology, bioengineering and tissue engineering that unravel the mechanisms of disease, regeneration and development.

Considers how engineering strategies can accelerate novel advances in regenerative medicine Takes an interdisciplinary approach, integrating different aspects of research, technology and application Provides up-to-date coverage on this rapidly developing area of medicine Presents insights from an experienced and cross-disciplinary group of researchers and practitioners with close links to industry

An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art and the future of these fields. Key selling features:Describes various bioreactors or stem cell culturing systemsReviews methods for stem cell expansion and differentiation for neural, cardiac, hemopoietic, mesenchymal, hepatic and other tissues cell typesDistinguishes different types of bioreactors intended for different operational scales of tissue engineering and cellular therapiesIncludes contributions from an international team of leaders in stem cell research

Bioreaction engineering is fundamental to the optimization of biotechnological processes and the production of biochemicals by enzymes, microbial, plant and animal cells and higher organisms.A reference text for postgraduate students and researchers in biochemical engineering and bioreactor design, Multiphase Bioreactor Design describes the fundamentals of bioreactors and their increasingly complex varieties. It highlights new methodologies for the analysis of multiphase bioreactors, namely hydrodynamics, image analysis and modeling. Specific chapters also provide information on the interactions between kinetic and transport phenomena, biocatalyst stability and cell physiology in non-conventional media such as organic solvents and pressurized gas phases.

Bioreactors for Health and Sustainability describes the basic concepts of chemical and biochemical kinetics, chemical reaction engineering, reactors design, ideal reactors, homogeneous and heterogeneous reactors. The book brings together in a single source the most significant types of reactors that use molecular (enzymes) and cells biocatalysts for biological applications, which range from enzyme reactors, microbial reactors, plant cell culture and reactors, photobioreactors, cell reactors, reactors for stem cell culture, reactors for tissue and organ engineering, microbioreactors, reactors for cellular agriculture products, to bioreactors for waste-water treatment. It elaborates on bioreactors from molecular level enzymes, to microbial, plant, animal and human cells and tissue and organs, and provides sustainable applications in industrial, environmental and health sectors. As such the book bridges the gap between the Engineering Sciences and Technology and Health Sciences areas. Bioreactors for Health and Sustainability brings a novel contribution to biotechnology that is based on the upstream of a biological process, which makes it of broad interest for professionals, researchers, and students in biological/biochemical engineering and bioengineering.Provides basic concepts of biological kinetics and bioreaction engineeringIncludes non-traditional topics in biochemical and biological engineeringAddresses cellular agricultural engineering

Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product.

The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders.

Presents the first 'Flowchart' of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc. Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book