Joel F. Liebman – författare

This book provides readers with examples of the synthesis and applications of large molecules and molecular assemblies designed for their unusual shapes or forms, or for some analytical or synthetic purpose. The chapters address the differing concepts of molecules and materials. Numerous references to original literature and to reviews are included. The topic of synthetic dendrimers is presented along with a novel descriptive system (fractal notation), with which complicated but regularly-shaped molecules may be described in a highly condensed fachion. The authors include individuals who have published extensively in the fields of the various chapters. The volume is appropriate as a primary text in a specials topics course in advanced organic or polymer chemistry, or as a supplementary text for these courses or for materials sciences courses. This book should be of interest to advanced graduates and graduate students in chemistry and related disciplines; and academic, industrial and government scientists in organic, inorganic, polymer and physical chemistry, biomedical and material sciences.

The past 15 years have seen tremendous progress in manganese chemistry, with the low cost of this metal making it an attractive choice as a functional group in organic syntheses. Surveying key compounds and reaction intermediates used in organic syntheses, this is the first volume in the Patai Series to focus on manganese in organic and organometallic chemistry. With contributions by leading experts, the book delivers the usual high quality of the Patai series. It also emphasizes novel applications in organic synthesis as well as technological trends in industrial, biomedical, and materials science.

The amide linkage is one of the most fundamental and widespread chemical bonds in nature, underlying the properties of a vast array of organic molecules, polymers, and materials, including peptides and proteins. Arthur Greenberg, Curt Breneman, and Joel Liebman’s peerless text provides comprehensive coverage of the experimental, structural, and computational findings that shed light on the chemical and physical properties of the amide linkage, as well as its emerging applications in materials and biotechnology.Chapters in The Amide Linkage highlight how this chemical bond factors in the design of enzyme inhibitors, cyclic peptides, antibacterial agents, and emerging nanotechnology applications. This one-of-a-kind study also: Discusses selected aspects of chemical reactions, structure, bonding, and energetics of the amide bond, including amide rotational barriers, stereochemistry, complexation, spectroscopy, and thermochemistryPresents specific applications to supramolecular and stereospecific synthesisDiscusses ke y aspects of peptide and protein chemistry–such as molecular recognition, conformation, and folding–in terms of the amide linkageIncludes chapters contributed by numerous eminent chemists and biochemistsOrganic, medicinal, polymer, and physical chemists, as well as biochemists and materials scientists, will find The Amide Linkage to be an invaluable addition to their professional libraries.

Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies.

The field of "Oxygen Activation" has attracted considerable interest recently, not only because it presents challenges in those fields of basic research that aim to understand the fundamental aspects of chemical and biological reactions that involve dioxygen, but also because of its wide range of practical implications in such diverse fields as medicine, synthesis of pharmaceuticals and other organic compounds, materials science, and atmospheric science. This is the second of two volumes that focus on the subject of oxygen activation, the first slanted toward chemistry and the second toward biological chemistry. We planned these volumes to be more general than many monographs of this sort, not as detailed summaries of the authors' own research but rather as general overviews of the field. Our choice of topics was strongly influenced by our syllabus for a course entitled "Oxygen Chemistry," which two of us have twice taught jointly at UCLA. Definition of important issues, horizons, and future prospects was an important goal, and, although totally comprehensive coverage was not possible, we believe that we have chosen a representative selection of research topics current to the field. We have targeted this work to a diverse audience ranging from professionals in fields from physics to medicine to beginning graduate students who are interested in rapidly acquiring the basics of this field.

The current volume consists of eight chapters which interweave various aspects of the structure, energetics and reactivity of organic free radicals, all combining pedagogical insights with current research. The first is by Walling in which a personalized overview is given by one of the modern pioneers of the discipline. In the next two chapters, Tsang, and Traeger and Kompe, present key thermochemical and kinetic quantities from the complementary vantage points of the studies of neutral and cationic species. The fourth chapter by Francisco and Montgomery discusses the armamentarium of modern theory as applied to species with unpaired electrons, while the next chapter by Goodman presents the theory, methodology and results from photoacoustic calorimetry, a novel and powerful experimental technique. Martinho Simoes and Minas da Piedade interrelate organometallic and free radical chemistry, while Greenberg and Liebman consider resonance energy and rearrangements as applied to small molecules and enzyme cofactors alike. The volume ends with the chapter by Tanko and Suleman, which describes the surprising and diverse solvent effects which modulate free radical chem- istry.This volume will make it apparent to entry-level graduate students and senior researchers alike that much is known and much remains to be done in both the qualitative understanding and quantitative insights of the chemistry of organic free radicals. Jose Artur Martinho Simoes Arthur Greenberg Joel F. Liebman vii Editorial Advisory Board WESTON T. BORDEN ALAN P.

The first book in the PATAI Series was published in 1964 and the Series will celebrate its 50th Anniversary in 2014. This "Golden Jubilee" is accompanied by the publication of the first volume on the chemistry of organogold.In the history of the PATAI Series there was, so far, no volume dedicated to gold alone. In 1999 we published a volume on The Chemistry of Gold and Silver Compounds. Since then a lot of new chemistry using gold has been developed and it is timely to focus a volume on methods and applications of organogold compounds in organic synthesis, reflecting the enormous progress which has been made in the use of gold compounds as reagents and catalysts.A second area of great importance covered in the book is the use of gold surfaces in the synthesis of peptides, proteins and other natural products. A whole range of applications in the area of biochemistry has resulted from these developments. A third area of interest is the synthesis and engineering of nanostructures, where organogold chemistry has opened the door for a wide range of methods and applications in the field of nanoscience and materials science. As with all new volumes, the chapters are first published online in Patai's Chemistry of Functional Groups. Once a volume is completed online, it is then published in print format. The printed book offers the traditional quality of the Patai Book Series, complete with an extensive index.

Nitrogen is unique among the non-carbon atoms in its ability to form single, double, and triple bonds with itself, giving rise to a wide range of organic-chemical groups containing several nitrogen atoms in different states and geometries. The present volume surveys the properties and chemical behaviour of all important nitrogen-rich organic-chemical groups, including azides, azimines, aziridines, diazo compounds, nitramines, nitrenes, nitrosamines, polyazine N-oxides, tetrazoles, triazanes, triazenes, and triazoles. A special focus lies on commercially important species which are used, e. g., as powerful explosives.PATAI's Chemistry of Functional Groups publishes comprehensive reviews on all aspects of specific functional groups. Each volume contains outstanding surveys on theoretical and computational aspects, NMR, MS, other spectroscopic methods and analytical chemistry, structural aspects, thermochemistry, photochemistry, synthetic approaches and strategies, synthetic uses and applications in chemical and pharmaceutical industries, biological, biochemical and environmental aspects. To date, almost 150 volumes have been published in the series.

The Chemistry of Nitrogen-rich Functional Groups, Volume 2 A series of advanced treatises founded by Professor Saul Patai and now under the general editorship of Professors Ilan Marek and Joel F. Liebman PATAI’s Chemistry of Functional Groups publishes comprehensive reviews on all aspects of specific functional groups. Each volume contains outstanding surveys on theoretical and computational aspects, NMR, MS, other spectroscopic methods and analytical chemistry, structural aspects, thermochemistry, photochemistry, synthetic approaches and strategies, synthetic uses and applications in chemical and pharmaceutical industries, biological, biochemical, and environmental aspects. To date, over 150 volumes have been published in the series. Recently Published Titles The Chemistry of Peroxides (Volume 2, 2 parts)The Chemistry of Organozinc Compounds (2 parts)The Chemistry of Anilines (2 parts)The Chemistry of Organomagnesium Compounds (2 parts)The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids (2 volumes, 4 parts)The Chemistry of Metal Enolates (2 parts)The Chemistry of Organocopper Compounds (2 parts)The Chemistry of Organomanganese CompoundsThe Chemistry of Organic Selenium and Tellurium Compounds (Volume 3, 2 parts)The Chemistry of Organic Selenium and Tellurium Compounds (Volume 4, 2 parts)The Chemistry of Organoiron CompoundsThe Chemistry of Metal PhenolatesThe Chemistry of Peroxides (Volume 3, 2 parts)The Chemistry of Organogold Compounds (2 parts)The Chemistry of Organoaluminum CompoundsThe Chemistry of Metal Enolates (Volume 2)The Chemistry of Metal Phenolates (Volume 2)The Chemistry of Hypervalent Halogen Compounds (2 parts)The Chemistry of Nitrogen-rich Functional GroupsThe Chemistry of Organoboron Compounds (2 parts)The Chemistry of Organocobalt CompoundsThe Chemistry of Organofluorine CompoundsPATAI Online PATAI’s Chemistry of Functional Groups is available in electronic format on Wiley Online Library.

The ultimate resource in organoboron chemistryProfessor Mark Gandelman and his colleagues delve deeply into the theory, structure, analysis, synthesis, and reactions of organoboron chemistry in The Chemistry of Organoboron Compounds. Organoborons are used heavily as highly efficient reagents in many reactions, including cross-coupling and radical reactions. The highly regarded authors have tied together organic-chemical and physico-chemical knowledge usually unavailable from a single source. The book focuses on the use of completely biodegradable "green" reagents, as opposed to environmentally hazardous heavy metal catalysts.The Chemistry of Organoboron Compounds delivers comprehensive and complete information on: The behavior of organoboron compoundsThe use of organoboron compounds in organic synthesisThe commercial applications of organoboron compoundsAs a volume in the celebrated Patai book series, The Chemistry of Organoboron Compounds includes all the features that readers of that series are used to enjoying, including a comprehensive index at the back of the book.

Strained Organic Molecule, Volume 38 considers the vast field of strained organic molecules. The book discusses energy and entropy; cyclopropane and cyclobutane; and unique strained groupings or building blocks. The text also describes the aesthetics, rearrangements, and topology of polycycles; kinetic and thermodynamic stability; and tetrahedral tetracoordinate carbon. The inverted tetrahedra, propellanes, buttaflanes, and paddlanes; planar methane and its derivatives; and five- and six-coordinaste carbon are also considered. Chemists will find the book invaluable.

Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies.

The title of this volume implies a progression of sorts from species of molecular size to a product described on the basis of continuum prop­ erties. The difference in approach from the standpoint of molecular be­ havior, on the one hand-more the forte of chemists-and from the standpoint of large-scale properties, on the other-more the province of chemical engineers and materials scientists-represents a severe cultural divide, but one with much potential for creative input from both sides. Chapter 1 of this volume attempts a broad survey of trends toward the synthesis of large, well-defined molecular systems with interesting physical, chemical, or material properties. Review articles with more de­ tailed treatments are emphasized. In Chapter 2, Newkome and Moore­ field summarize work on synthesis of /I cascade" molecules. Next, Denti, Campagna, and Balzani describe the synthesis of assemblies with con­ nected metal-containing chromophore units which transmit electrons or electronic energy in defined ways. In Chapter 4 Wuest describes the con­ struction of hydrogen-bonded organic networks, and in Chapter 5 Michl defines a molecular-level construction set. Finally, Jaszczak points out how nature's attempts over geological time spans are emulated by recent human synthetic activity in the fullerene arena, through the appearance of various morphologies of natural graphite. The book concludes with a method for describing fractal-like mole­ cules, and an index based on the method for appropriate compounds described in the text.

The current volume consists of eight chapters which interweave various aspects of the structure, energetics and reactivity of organic free radicals, all combining pedagogical insights with current research. The first is by Walling in which a personalized overview is given by one of the modern pioneers of the discipline. In the next two chapters, Tsang, and Traeger and Kompe, present key thermochemical and kinetic quantities from the complementary vantage points of the studies of neutral and cationic species. The fourth chapter by Francisco and Montgomery discusses the armamentarium of modern theory as applied to species with unpaired electrons, while the next chapter by Goodman presents the theory, methodology and results from photoacoustic calorimetry, a novel and powerful experimental technique. Martinho Simoes and Minas da Piedade interrelate organometallic and free radical chemistry, while Greenberg and Liebman consider resonance energy and rearrangements as applied to small molecules and enzyme cofactors alike. The volume ends with the chapter by Tanko and Suleman, which describes the surprising and diverse solvent effects which modulate free radical chem- istry.This volume will make it apparent to entry-level graduate students and senior researchers alike that much is known and much remains to be done in both the qualitative understanding and quantitative insights of the chemistry of organic free radicals. Jose Artur Martinho Simoes Arthur Greenberg Joel F. Liebman vii Editorial Advisory Board WESTON T. BORDEN ALAN P.

The title of this volume implies a progression of sorts from species of molecular size to a product described on the basis of continuum prop­ erties. The difference in approach from the standpoint of molecular be­ havior, on the one hand-more the forte of chemists-and from the standpoint of large-scale properties, on the other-more the province of chemical engineers and materials scientists-represents a severe cultural divide, but one with much potential for creative input from both sides. Chapter 1 of this volume attempts a broad survey of trends toward the synthesis of large, well-defined molecular systems with interesting physical, chemical, or material properties. Review articles with more de­ tailed treatments are emphasized. In Chapter 2, Newkome and Moore­ field summarize work on synthesis of /I cascade" molecules. Next, Denti, Campagna, and Balzani describe the synthesis of assemblies with con­ nected metal-containing chromophore units which transmit electrons or electronic energy in defined ways. In Chapter 4 Wuest describes the con­ struction of hydrogen-bonded organic networks, and in Chapter 5 Michl defines a molecular-level construction set. Finally, Jaszczak points out how nature''s attempts over geological time spans are emulated by recent human synthetic activity in the fullerene arena, through the appearance of various morphologies of natural graphite. The book concludes with a method for describing fractal-like mole­ cules, and an index based on the method for appropriate compounds described in the text.

The field of "Oxygen Activation" has attracted considerable interest recently, not only because it presents challenges in those fields of basic research that aim to understand the fundamental aspects of chemical and biological reactions that involve dioxygen, but also because of its wide range of practical implications in such diverse fields as medicine, synthesis of pharmaceuticals and other organic compounds, materials science, and atmospheric science. This is the second of two volumes that focus on the subject of oxygen activation, the first slanted toward chemistry and the second toward biological chemistry. We planned these volumes to be more general than many monographs of this sort, not as detailed summaries of the authors'' own research but rather as general overviews of the field. Our choice of topics was strongly influenced by our syllabus for a course entitled "Oxygen Chemistry," which two of us have twice taught jointly at UCLA. Definition of important issues, horizons, and future prospects was an important goal, and, although totally comprehensive coverage was not possible, we believe that we have chosen a representative selection of research topics current to the field. We have targeted this work to a diverse audience ranging from professionals in fields from physics to medicine to beginning graduate students who are interested in rapidly acquiring the basics of this field.