Jörg P. Müller – författare

This second edition volume expands on the previous edition with discussions on the latest advancements in protein tyrosine phosphatases (PTP) research used to investigate these essential enzymes and new inhibitors. The new techniques covered in the chapters of this book include studying enzymes in vitro, in cells, and in animal models through proteomics, genomics, and structural biology. Furthermore, new advances in pharmacology and drug design have contributed to the developing novel therapeutics that target PTPs.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Protein Tyrosine Phosphatases: Methods and Protocols, Second Edition is a valuable resource for both experienced and novel researchers in this field, and will lead to discoveries and accelerated progress in the field of PTP, signal transduction, and drug development.

This second edition volume expands on the previous edition with discussions on the latest advancements in protein tyrosine phosphatases (PTP) research used to investigate these essential enzymes and new inhibitors. The new techniques covered in the chapters of this book include studying enzymes in vitro, in cells, and in animal models through proteomics, genomics, and structural biology. Furthermore, new advances in pharmacology and drug design have contributed to the developing novel therapeutics that target PTPs.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Protein Tyrosine Phosphatases: Methods and Protocols, Second Edition is a valuable resource for both experienced and novel researchers in this field, and will lead to discoveries and accelerated progress in the field of PTP, signal transduction, and drug development.

This book constitutes revised selected papers from the 13th International Workshop on Engineering Multi-Agent Systems, EMAS 2025, which took place in Detroit, USA, during May 19–20, 2025.The 13 full papers in this book were carefully reviewed and selected from a total of 16 submissions. The book also contains one paper on the community roadmap for EMAS. The contributions focus on topics such as agent-oriented software engineering, programming multi-agent systems, declarative agent languages and technologies, artificial intelligence, and machine learning.

This book constitutes the proceedings of the 12th German Conference on Multiagent System Technologies, MATES 2014, held in Stuttgart, Germany, in September 2014. The 9 full papers and 7 short papers included in this volume were carefully reviewed and selected from 31 submissions. The book also contains 2 invited talks. The papers are organized in topical sections named: mechanisms, negotiation, and game theory; multiagent planning, learning, and control; and multiagent systems engineering, modeling and simulation.

The work on Autonomic Road Transport Support (ARTS) presented here aims at meeting the challenge of engineering autonomic behavior in Intelligent Transportation Systems (ITS) by fusing research from the disciplines of traffic engineering and autonomic computing. Ideas and techniques from leading edge artificial intelligence research have been adapted for ITS over the last 30 years. Examples include adaptive control embedded in real time traffic control systems, heuristic algorithms (e.g. in SAT-NAV systems), image processing and computer vision (e.g. in automated surveillance interpretation). Autonomic computing which is inspired from the biological example of the body’s autonomic nervous system is a more recent development. It allows for a more efficient management of heterogeneous distributed computing systems. In the area of computing, autonomic systems are endowed with a number of properties that are generally referred to as self-X properties, including self-configuration, self-healing, self-optimization, self-protection and more generally self-management. Some isolated examples of autonomic properties such as self-adaptation have found their way into ITS technology and have already proved beneficial.   This edited volume provides a comprehensive introduction to Autonomic Road Transport Support (ARTS) and describes the development of ARTS systems. It starts out with the visions, opportunities and challenges, then presents the foundations of ARTS and the platforms and methods used and it closes with experiences from real-world applications and prototypes of emerging applications. This makes it suitable for researchers and practitioners in the fields of autonomic computing, traffic and transport management and engineering, AI, and software engineering. Graduate students will benefit from state-of-the-art description, the study of novel methods and the case studies provided.

This book constitutes the proceedings of the 13th German Conference on Multiagent System Technologies, MATES 2015, held in Cottbus, Germany, in September 2015.The 11 full papers papers presented together with 2 short papers, 1 invited paper and 4 extended abstracts of doctoral papers in this volume were carefully reviewed and selected from 27 submissions. The papers are organized in topical sections on MAS engineering, modeling, and simulation; smart things working together; and innovative and emerging applications of MAS.

This book constitutes revised, selected, and invited papers from the 4th International Workshop on Engineering Multi-Agent Systems, EMAS 2016, held in Singapore, in May 2016, in conjunction with AAMAS. The 10 full papers presented in this volume were carefully reviewed and selected from 14 submissions. The book also contains 2 invited papers; extended versions of AAMAS 2016 demonstration abstracts. EMAS deals with MAS software engineering processes, methodologies and techniques; Programming languages for MAS; Formal methods and declarative technologies for the specification, validation and verification of MAS; and development tools.