John Bernard - Böcker

'The mind unlearns with difficulty what has long been impressed upon it. ' Seneca Reductionism, is, without question, the most successful analytical approach available to the experimental scientist. With the advent of techniques for cloning and sequencing DNA, and the development of a variety of molecular probes for localizing macromolecules in cells and tissues, the biologist now has available the most powerful reductionist tools ever invented. The application of these new technologies has led to a veritable explosion of facts regarding the types and organization of nucleotide sequences present in the genomes of eukaryotes. These data offer a level of precision and predictability which is unparalleled in biology. Recombinant DNA techniques were initially developed to gather information about the structure and organization of the DNA sequences within a genome. The power and potential of these techniques, however, extend far beyond simple data collection of this kind. In an attempt to use the new technology as a basis for analyzing development and evolution, attention was first focused on the topic of gene regulation, an approach that had proven so successful in prokaryotes. It is now clear that this has not been an adequate approach. Lewin (1984) has quoted Brenner as stating 'at the beginning it was said that the answer to the understanding of development was going to come from a knowledge of the molecular mechanisms of gene control. I doubt whether anyone believes this any more.

Machiavelli (1469-1527) is the seminal figure in early modern intellectual history for those living, or wishing to live, in a functional democracy. What Machiavelli is primarily about, and what makes him indispensable to those of us living in and struggling to preserve democracy in America, is the sum of individual and collective qualities required of a citizen, or what he termed virtu: a host of traits ranging from manliness to boldness, ingenuity, excellence, self-esteem, and even stoic resignation. In a narrative spanning Machiavelli's life and work as one of the world's most fascinating philosophers, Bernard illuminates for the modern reader just how relevant his insights are to our own evolving debate on the appropriate relations between religion and politics, church and state.Besides offering a detailed sketch of Machiavelli as a chancellor in the Italian Soderini Republic (1498-1512), this book examines the man's political philosophy, particularly his complex view of republics and principalities, in The Prince, the Discourses, and the Florentine Histories. It also establishes the importance of Machiavelli's writing as it evolved during his exile, especially in the reflexive passages of his plays Mandragola and Clizia. The book concludes with the potential uses of Machiavellism in 21st-century mass democracies, as well as presenting ways in which his legacy lives on in our own activities as citizens in a democracy.