John Buckingham – författare

This first supplement to the new Edition of the Dictionary of Organic Compounds (DOC), published in nine volumes in 1995, extends the literature coverage of the dictionary to mid-1996. It includes over 2,500 entries, some of which are major updates to entries which appeared in volumes 1-9, while the majority are new entries based on the DOC team's ongoing review of the current literature. Some of these cover newly synthesized molecules of research interest, while others refer to known compounds which have come into prominence, for example as synthetic reagents in new methodoligies. The supplement contains its own name, molecular formula and CAS registry number indexes. For any library of research group where organic chemistry or related disciplines are studied or researched, DOC is the prime literature source summarising the current state of knowledge in this important discipline, year-by-year and fully up-to-date. This book should be of interest to chemists, biochemists, biologists and pharmacologists working within academic, industrial or government organisations.

This book includes over 2,500 entries of organic compounds, some of which cover recently synthesized molecules of research interest, while others refer to known compounds which have come into prominence. It is an invaluable resource for Organic and Pharmaceutical chemists.

This Dictionary draws and checks the structure diagrams to ensure their accuracy and consistency, and presents the data within entries of natural products in a logical manner which reconciles as far as possible inconsistencies and inaccuracies in the literature.

Containing fully authenticated data on virtually all known natural products, the "Dictionary of Natural Products", main work, published in 1993 was the end result of over 12 years compilation and editing by a large team of contributors. The resulting Dictionary contains 100,000 natural products and their derivatives organized into approximately 35,000 entries. Volume 9 of the Dictionary contains the result of a thorough review of the natural product literature for the year 1992-3, the results of which are presented as a mixture of new entries and updated entries containing modified information. The following categories of natural products are covered: amino acids, peptides and protiens; carbohydrates; nucleosides and nucleotides; lipids; antibiotics; alkaloids; steroids and terpenoids; flavonoids; lignans; lichen acids; coumarins; polyacetylenes; polypyrroles; semiochemicals and other miscellaneous aliphatic compounds; and all other classes of miscellaneous metabolites. A particular feature of the Dictionary is the care which has been taken to draw and check the structure diagrams to ensure their accuracy and consistency, and to present the data within entries in a logical manner which reconciles as far as possible inconsistencies and inaccuracies in the literature, as determined by the subject editors. Careful attention has also been taken with nomenclature to ensure user-friendly access to all of the data. All of the contents are fully indexed by name, molecular formula, Chemical Abstracts Service (CAS) Registry Number and species from which isolated. An additional unique feature is the type of compound classification scheme which has been evolved for this Dictionary to list all natural products under one or more headings, bringing closely related compounds together under one index heading. Extensive references, labelled to show their content, are listed for each entry, allowing rapid location of data of a particular type, e.g. spectroscopic information. The "Dictionary of Natural Products" is a reference source on natural products, with Volume 9 (the second supplementary volume) a useful addition to keep the Dictionary up-to-date.

In the Fifties, a tremendous conceptual breakthrough was about to take place in science, revolutionising the way we think about the molecules of life. The story ranged across laboratories throughout Europe in which the protagonists built molecular models that promised to unlock the natural world's secrets. When the breakthrough finally occurred, some of the participants became widely honoured, while others were unjustly neglected and died in obscurity. This all happened in the 1850s, not the 1950s.By the mid-nineteenth century, chemists had established that many natural products were made of just three elements - carbon, oxygen and hydrogen. How could this be true? How could such extraordinarily complicated substances, even man himself, be made of nothing but charcoal and air? The molecules were the fundamental substances of organic chemistry, the building blocks not only of the DNA unravelled a century later, but of the mass of natural products and synthetic substances that were to dominate the modern world.

Written by the team that brought you the prestigious Dictionary of Natural Products (DNP), the Natural Products Desk Reference provides a concise overview of the key structural types of natural products and their interrelationship. A structurally diverse group, ranging from simple aliphatic carbon chains to high molecular weight proteins, natural products can usually be classified into one or more groups. The text describes these major types, including flavonoids, carbohydrates, terpenoids, polyketides, and lipids, and it illustrates them with accurate chemical structures, demonstrating the biosynthetic relationships between groups. Provides details of specialist natural products journals and journals in biochemistry, biology, medicinal chemistry, organic chemistry, pharmacy, pharmacology, and toxicology that may contain important information on natural productsIncludes types of names that can be used for natural products, comprising functional parent names, trivial names, systematic names, semisystematic names, and semitrivial namesCovers stereochemistry topics specific to natural productsPresents an overview of the natural world and its classification, focusing on organisms that are the richest sources of natural productsDetails known types of natural product skeletons with their numbering, or where there are skeletal variations within the group, an illustration is given of a representative example compoundDiscusses carbohydrate nomenclature impacts on stereochemistry, and on the nomenclature of compounds other than mainstream carbohydratesReviews general precautions for handling chemicals in a laboratory environment, highlighting hazards resulting from the acute toxicological and pharmacological properties of some classes of natural products and hazards associated with the use o

Encouraged by the medicinal success of quinine, early 19th century scientists hoped strychnine, another plant alkaloid with remarkable properties, might also become a new weapon against disease. Physicians tried for over a century, despite growing evidence to the contrary, to treat everything from paralysis to constipation with it. But strychnine proved only to be disappointingly deadly-relegating its fate almost entirely to animal control, the dangerous adulteration of foods, and criminal exploits.The NOTORIOUS and TRUE story of how a POISONOUS alkaloid...Bitter Nemesis: The Intimate History of Strychnine presents a scholarly and compelling history of this fascinating chemical substance from its discovery to present times. A renowned editor for the Dictionary of Natural Products, Dr. John Buckingham fuses his eclectic interests into an extraordinary mix of original research spanning the realms of history, medicine, literature, chemistry, and forensics....Changed the course of HISTORY!Uncovering details and logistics from the earliest experiments performed in an era when proper scientific trials for testing new drugs were still in their infancy, the author explores strychnine's trial-and-error contributions to scientific, medical, and forensic developments. He also investigates historical milestones and the perception of strychnine in popular culture-including criminal notoriety, accidental misuse, and new claims of strychnine's benefits that extend through to the present day.Juxtaposing the real trials, mistrials, and persistent curiosity associated with one of history's most notorious pharmaceutical failures, Bitter Nemesis offers rare insight into the anarchic, yet inspired landscape, practices, and legacy of 19th century science.

Encouraged by the medicinal success of quinine, early 19th century scientists hoped strychnine, another plant alkaloid with remarkable properties, might also become a new weapon against disease. Physicians tried for over a century, despite growing evidence to the contrary, to treat everything from paralysis to constipation with it. But strychnine proved only to be disappointingly deadly-relegating its fate almost entirely to animal control, the dangerous adulteration of foods, and criminal exploits.The NOTORIOUS and TRUE story of how a POISONOUS alkaloid...Bitter Nemesis: The Intimate History of Strychnine presents a scholarly and compelling history of this fascinating chemical substance from its discovery to present times. A renowned editor for the Dictionary of Natural Products, Dr. John Buckingham fuses his eclectic interests into an extraordinary mix of original research spanning the realms of history, medicine, literature, chemistry, and forensics....Changed the course of HISTORY!Uncovering details and logistics from the earliest experiments performed in an era when proper scientific trials for testing new drugs were still in their infancy, the author explores strychnine's trial-and-error contributions to scientific, medical, and forensic developments. He also investigates historical milestones and the perception of strychnine in popular culture-including criminal notoriety, accidental misuse, and new claims of strychnine's benefits that extend through to the present day.Juxtaposing the real trials, mistrials, and persistent curiosity associated with one of history's most notorious pharmaceutical failures, Bitter Nemesis offers rare insight into the anarchic, yet inspired landscape, practices, and legacy of 19th century science.

Written by the team that brought you the prestigious Dictionary of Natural Products (DNP), the Natural Products Desk Reference provides a concise overview of the key structural types of natural products and their interrelationship. A structurally diverse group, ranging from simple aliphatic carbon chains to high molecular weight proteins, natural products can usually be classified into one or more groups. The text describes these major types, including flavonoids, carbohydrates, terpenoids, polyketides, and lipids, and it illustrates them with accurate chemical structures, demonstrating the biosynthetic relationships between groups. Provides details of specialist natural products journals and journals in biochemistry, biology, medicinal chemistry, organic chemistry, pharmacy, pharmacology, and toxicology that may contain important information on natural products Includes types of names that can be used for natural products, comprising functional parent names, trivial names, systematic names, semisystematic names, and semitrivial names Covers stereochemistry topics specific to natural products Presents an overview of the natural world and its classification, focusing on organisms that are the richest sources of natural products Details known types of natural product skeletons with their numbering, or where there are skeletal variations within the group, an illustration is given of a representative example compound Discusses carbohydrate nomenclature impacts on stereochemistry, and on the nomenclature of compounds other than mainstream carbohydrates Reviews general precautions for handling chemicals in a laboratory environment, highlighting hazards resulting from the acute toxicological and pharmacological properties of some classes of natural products and hazards associated with the use of organic solventsIn addition to being a companion resource to the DNP, the Natural Products Desk Reference provides you with a mass of other useful information which can sometimes be hard to track down. In compiling it, the authors have drawn on over 20 years of day-to-day experience in the description and classification of all types of natural product.