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Protein NMR Spectroscopy, Second Edition combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution.
Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments.
Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.
The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field.
Provides an understanding of the theoretical principles important for biological NMR spectroscopy Demonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experiments Allows for the capability of designing effective experimental protocols for investigations of protein structures and dynamics Includes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods938 kr
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For most of the post-war period, alcohol problems had been viewed primarily as individual problems. During the 1970s and 1980s, research highlighted the importance of larger socio-economic factors in shaping drinking levels, patterns and problems. However, it largely ignored a paramount force which shaped this larger socio-economic environment: the modern multinational corporation.
The aim of this book, originally published in 1985, was to demonstrate, on the basis of historical analysis, that transnational corporate structures and marketing strategies exercised a powerful impact on the availability and consumption of alcoholic beverages in both developed and developing marketing economies. While the authors did not want to suggest a single causal relationship between corporate strategies and the consumption of alcoholic beverages, the implications of their work were of the greatest significance to public health throughout the world. The book was an indispensable work for those interested in public health, alcoholism, and multinational business at the time. Today it can be read in its historical context.
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For most of the post-war period, alcohol problems had been viewed primarily as individual problems. During the 1970s and 1980s, research highlighted the importance of larger socio-economic factors in shaping drinking levels, patterns and problems. However, it largely ignored a paramount force which shaped this larger socio-economic environment: the modern multinational corporation.
The aim of this book, originally published in 1985, was to demonstrate, on the basis of historical analysis, that transnational corporate structures and marketing strategies exercised a powerful impact on the availability and consumption of alcoholic beverages in both developed and developing marketing economies. While the authors did not want to suggest a single causal relationship between corporate strategies and the consumption of alcoholic beverages, the implications of their work were of the greatest significance to public health throughout the world. The book was an indispensable work for those interested in public health, alcoholism, and multinational business at the time. Today it can be read in its historical context.
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