John Crowley – författare

"Crowley crafts images and scenes that are exceptionally vivid. A joy to revisit" - Goodreads Reviewer"This is a marvellous book. Well written, well researched and based on the most intriguing historical facts" - Amazon ReviewerIn the 1970s, an historian named Pierce Moffett moves to the New England countryside to write a book about Ægypt, driven by an idea he dare not believe: that wondrous and magical powers once governed the universe; that the physical laws of this universe once changed and may yet change again. The notion is not his alone. Something waits at the locked estate of Fellowes Kraft - author of romances about Will Shakespeare and Giordano Bruno and Dr. John Dee - something for which Pierce and those near him have long sought without knowing it: a key, perhaps, to Ægypt...

In the drowsy tranquility of Little Belaire, the Truthful Speakers lead lives of peaceful self-sufficiency ignoring the depopulated wilderness beyond their narrow borders. It is a society untouched by pain or violence and the self-destroying 'Angels' of the past are barely remembered. But when Rush That Speaks leaves his home on a pilgrimage of self-enlightenment, he finds a landscape haunted by myths and memories. The overgrown ruins reflect a world outside that is stranger than his people ever dreamed ...

A master literary stylist, John Crowley has carried readers to diverse and remarkable places in his award-winning, critically acclaimed novels -- from his classic fable, Little, Big, to his New York Times Notable Book, The Translator. Now, for the first time, all of his short fiction has been collected in one volume, demonstrating the scope, the vision, and the wonder of one of America's greatest storytellers. Courage and achievement are celebrated and questioned, paradoxes examined, and human frailty appreciated in fifteen tales, at once lyrical and provocative, ranging fromthe fantastic to the achingly real. Be it a tale of an expulsion from Eden, a journey through time, the dreams of a failed writer, ora dead woman's ambiguous legacy, each story in Novelties & Souvenirs is a glorious reading experience, offering delights to be savored ...and remembered.

For many generations the Just have been at war with the Protectors. In their strange world, supported by a huge pillar poised in the vast and mysterious Deep, ritual bloodshed and sorcery have obsessed the inhabitants since the beginning of time.Half human, half machine, sexless and hairless, the Visitor from the skies enters the world on a mission unknown even to himself. Is he a peacemaker between the warrior clans, an observer, or, with his phenomenal qualities, a warrior himself, the likes of which this planet has never seen before? Only time can tell, and time is something that his makers have not allowed for ...

Since the third edition of this handbook, significant advances have transformed the field of oncology. Most cancer types now offer multiple treatment options, with immunotherapies and targeted therapies becoming the standard of care. Master protocols, which allow the addition of new treatment arms without requiring new protocols, have gained popularity—not only to expedite the approval process for new therapies but also to ensure that patients receive the most beneficial treatments tailored to their individual needs. This revised edition features contributions from leading cancer trial statisticians, providing expert insights into modern oncology trial design and methodology. The handbook is structured into five key parts:Part 1: Cancer prevention and screening trial designs, including risk prediction models and prevention trialsPart 2: Early-phase trial designs, covering dose-finding studies, selection designs, and multi-strata trialsPart 3: Late-stage trial designs, including approaches for IO therapies, cure-rate models, targeted agents, and considerations for pediatric oncology trialsPart 4: Trial conduct and operations, addressing best practices for Data Monitoring Committees (DMCs), SWOG/CRAB calculators, pragmatic trials, and clinical trial innovationPart 5: Beyond primary endpoints, exploring surrogate endpoints, microbiome research, patient-reported outcomes (PROs), and tree-based partitioning methodsThis updated edition provides a comprehensive resource for researchers, clinicians, and statisticians involved in the evolving landscape of oncology clinical trials.

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents.Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs.Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials.Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added.Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

This book provides seven studies that address major issues such as the human rights and human security nexus, gender aspects of human security, ethical and environmental challenges, human security as a basic element for a policy framework, the human security agenda developed by the Human Security Network, and debates on human security within the United Nations. Building on its variety of themes, the book takes account of the complexity and scope of the concept of human security, and proposes thereby to refresh and enrich discussionContributors are internationally renowned experts in the different subfields of human securityOffers an overview of current trends and insights on what is at stake if the international community is to maintain the momentum created a few years ago when the concept of human security emergedDesigned to help both newcomers and experts in the field of human securityReaders will find inspiration in the new developments of a concept that aims to shape practical action to meet the needs of the most vulnerable

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents.Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs.Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials.Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added.Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Edgewood is many houses, all put inside each other, or across each other. It's filled with and surrounded by mystery and enchantment: the further in you go, the bigger it gets. Smoky Barnable, who has fallen in love with Daily Alice Drinkwater, comes to Edgewood, her family home, where he finds himself drawn into a world of magical strangeness.Crowley's work has a special alchemy - mixing the world we know with an imagined world which seems more true and real. Winner of the WORLD FANTASY AWARD, LITTLE, BIG is eloquent, sensual, funny and unforgettable, a true Fantasy Masterwork.Winner of the WORLD FANTASY AWARD FOR BEST NOVEL, 1982.

Praise for John Crowley:"Like a magus, John Crowley shares his secrets generously, allowing us to believe that his book is revealing the true and glorious nature of the world and the reader's own place within it."—Village Voice"[Crowley] transforms the lead of daily life into seriously dazzling artistic gold."—NewsdayOften de-scribed as an alchemical allegory, John Crowley instead decided this is "the first science fiction novel." After all "it's fiction; it's about the possibilities of a science; and it's a novel." No matter what else it might be, it's definitely "one of the great outlandish stories in Western literature." With eight appropriately weird and fascinating black and white woodcuts by Theo Fadel.John Crowley was born in Presque Isle, Maine, in 1942. He moved to New York City after college in Indiana to make movies, and did find work in docu-mentary films, an occupation he still pursues. He has published many novels including the Ae-gypt quartet and Little, Big. He teaches creative writing at Yale University. In 1992 he received the Award in Literature from the American Academy and Institute of Arts and Letters. He finds it more gratifying that almost all his work is still in print.Theo Fadel has a BA in Archeology (Bryn Mawr) and a Master of Architecture from Co-lumbia University. Currently her studio is in Easthampton, and she's been in Massachusetts less than a hundred years. This is the first book she has illustrated.

The Atlas of the Irish Revolution is a landmark publication that presents scholarship on the revolutionary period in a uniquely accessible manner. Featuring over 200 original maps and 300 images, the Atlas includes 120 contributions by leading scholars from a range of disciplines. They offer multiple perspectives on the pivotal years from the 1912 Home Rule crisis to the end of the Irish Civil War in 1923. Using extensive original data (much of it generated from newly-released archival material), researchers have mapped social and demographic change, political and cultural activity, state and non-state violence and economic impacts. The maps also portray underlying trends in the decades before the revolution and capture key aspects of the revolutionary aftermath. They show that while the Irish revolution was a 'national' event, it contained important local and regional variations that were vital to its outcomes. The representation of island-wide trends stand alongside street-level, parish, county and provincial studies that uncover the multi-faceted dynamics at play.The Atlas also captures the international dimensions of a revolution that occurred amidst the First World War and its tumultuous aftermath.Revolutionary events in Ireland received global attention because they profoundly challenged the British imperial project. Key revolutionaries operated transnationally before, during and after the conflict, while the Irish diaspora provided crucial support networks. The often neglected roles of women and workers are illuminated, while commentators consider the legacies of the revolution, including collective memories, cultural representations and historical interpretations. The Atlas of the Irish Revolution brings history to life for general readers and students, as well as academics. It represents a ground-breaking contribution to the historical geography of these compelling years of conflict, continuity and change.

This new volume in the award-winning Atlas Series presents fresh perspectives on, and a nuanced understanding of, the history of the Irish Civil War (1922-3). The centenary of the Civil War has prompted wide-ranging research into that tumultuous and complex period in Irish history. Featuring contributions from over ninety leading scholars from a range of disciplines, this book provides new insights into the conflict's regional, national and international dimensions. It includes the first-ever listing of Civil War fatalities and original explorations of issues including propaganda, gender, trauma, culture, labour, land and class. Produced in partnership with the National Library of Ireland with support from the Department of Tourism, Culture, Arts, Gaeltacht, Sport and Media, the Atlas of the Irish Civil War: New perspectives is richly illustrated with over 400 photographs, archival documents and a series of newly created original maps. From the research team that produced the widely acclaimed Atlas of the Irish Revolution, this volume represents a major and accessible contribution to the historiography of a conflict that has cast a long shadow over Irish life.

The Iveragh Peninsula, often referred to as the 'Ring of Kerry', is one of Ireland's most dramatic and beautiful landscapes. This cultural atlas, comprising over fifty individual chapters and case studies, provides the reader with a broad range of perspectives on the peninsula and the human interactions with it since prehistoric times to the present day. Although not a conventional atlas, it contains many historic and newly commissioned maps. It also combines many different approaches towards understanding the distinctive character - both physical and human - of this unique landscape.The opening chapters explore the physical and environmental setting of the peninsula. Subsequent chapters deal with its development over the millennia and the influences that have shaped it. All aspects of Iveragh's past and present are considered, using the evidence of disciplines such as archaeology, art-history, cartography, folklore, geography, geology, history, mythology and zoology. The range of topics that arise from this approach is tremendously wide, and occasionally surprising.Given its status as a peninsula projecting into the Atlantic, the history and culture of the Iveragh Peninsula have been moulded by external influences as well as by regional and national ones.Its story is multi-layered, involving the imprint of mythological as well as historic settlers and invaders. The peninsula has witnessed significant periods of transition, perhaps none more so than in the present era. This book seeks to deepen and illuminate our understanding of its landscape, history and heritage.

The Great Famine is possibly the most pivotal event/experience in modern Irish history. Its global reach and implications cannot be underestimated. In terms of mortality, it is now widely accepted that over a million people perished between the years 1845-1852 and at least one million and a quarter fled the country, the great majority to North America, some to Australia and a significant minority ((0.3 million) to British cities. Ireland had been afflicted by famine before the events of the 1840s; however the Great Famine is marked by both its absolute scale and its longevity. It is also better remembered because it was the most recent and best documented famine. This atlas comprising over fifty individual chapters and case studies will provide readers with a broad range of perspectives and relevant insights into this tragic event. The atlas begins by acknowledging the impossibility of adequately representing the Great Famine or any major world famine.Yet by exploring a number of themes from a reconstruction of pre-Famine Ireland onwards to an exploration of present-day modes of remembering; by the use of over 150 highly original computer generated parish maps of population decline, social transformation and other key themes between the census years 1841 and 1851: and through the use of poetry, contemporary paintings and accounts, illustrations and modern photography, what this atlas seeks to a achieve is a greater understanding of the event and its impact and legacy. This atlas seeks to try and bear witness to the thousands and thousands of people who died and are buried in mass Famine pits or in fields and ditches, with little or nothing to remind us of their going. The centrality of the Famine workhouse as a place of destitution is also examined in depth. Likewise the atlas seeks to represent and understand the conditions and experiences of the many thousands who emigrated from Ireland in those desperate years. Included are case studies of famine emigrants in cities such as Liverpool, Glasgow, New York and Toronto.A central concern of the atlas is to seek to understand why a famine of this scale should occur in a nineteenth-century European country, albeit a country which was subject to imperial rule. In addition, it seeks to reveal in detail the working-out and varying consequences of the Famine across the island. To this end, apart from presenting an overall island-wide picture, Famine experiences and patterns will be presented separately for the four provinces. These provincial explorations will be accompanied by intimate case studies of conditions in particular localities across the provinces. The atlas also seeks to situate the Great Irish Famine in the context of a number of world famines. To achieve these goals and understandings, the atlas includes contributions from a wide range of scholars who are experts in their fields - from the arts, folklore, geography, history, archaeology, Irish and English languages and literatures.

Praise for the Aegypt sequence: "With Little, Big, Crowley established himself as America's greatest living writer of fantasy. Aegypt confirms that he is one of our finest living writers, period." -Michael Dirda "A dizzying experience, achieved with unerring security of technique." -The New York Times Book Review "A master of language, plot, and characterization." -Harold Bloom "The further in you go, the bigger it gets." -James Hynes "The writing here is intricate and thoughtful, allusive and ironic...Aegypt bears many resemblances, incidental and substantive, to Thomas Pynchon's wonderful 1966 novel The Crying of Lot 49." -USA Today "An original moralist of the same giddy heights occupied by Thomas Mann and Robertson Davies." -San Francisco Chronicle This is the fourth novel-and much-anticipated conclusion-of John Crowley's astonishing and lauded Aegypt sequence: a dense, lyrical meditation on history, alchemy, and memory.Spanning three centuries, and weaving together the stories of Renaissance magician John Dee, philosopher Giordano Bruno, and present-day itinerant historian and writer Pierce Moffitt, the Aegypt sequence is as richly significant as Lawrence Durrell's Alexandria Quartet or Anthony Powell's Dance to the Music of Time. Crowley, a master prose stylist, explores transformations physical, magical, alchemical, and personal in this epic, distinctly American novel where the past, present, and future reflect each other. "It is a work of great erudition and deep humanity that is as beautifully composed as any novel in my experience." -Washington Post Book World "An unpredictable, free-flowing, sui generis novel." -Los Angeles Times "With Endless Things and the completion of the Aegypt cycle, Crowley has constructed one of the finest, most welcoming tales contemporary fiction has to offer us." -Book Forum "Crowley's peculiar kind of fantasy: a conscious substitute for the magic in which you don't quite believe any more." -London Review of Books "A beautiful palimpsest as complex, mysterious and unreliable as human memory."-Seattle Times "This year, while millions of Harry Potter fans celebrated and mourned the end of their favorite series, a much smaller but no less devoted group of readers marked another literary milestone: the publication of the last book in John Crowley's Aegypt Cycle." -Matt Ruff "Crowley's eloquent and captivating conclusion to his Aegypt tetralogy finds scholar Pierce Moffet still searching for the mythical Aegypt, an alternate reality of magic and marvels that have been encoded in our own world's myths, legends and superstitions. Pierce first intuited the realm's existence from the work of cult novelist Fellowes Kraft. Using Kraft's unfinished final novel as his Baedeker, Pierce travels to Europe, where he spies tantalizing traces of Aegypt's mysteries in the Gnostic teachings of the Rosicrucians, the mysticism of John Dee, the progressive thoughts of heretical priest Giordano Bruno and the "chemical wedding" of two 17th-century monarchs in Prague. Like Pierce's travels, the final destination for this modern fantasy epic is almost incidental to its telling.With astonishing dexterity, Crowley (Lord Byron's Novel) parallels multiple story lines spread across centuries and unobtrusively deploys recurring symbols and motifs to convey a sense of organic wholeness. Even as Pierce's quest ends on a fulfilling personal note, this marvelous tale comes full circle to reinforce its timeless themes of transformation, re-creation and immortality." -Publishers Weekly Locus Award finalist John Crowley was born in the appropriately liminal town of Presque Isle, Maine. His most recent novel is Four Freedoms. He teaches creative writing at Yale University. In 1992 he received the Award in Literature from the American Academy and Institute of Arts and Letters. He finds it more gratifying that almost all of his work is still in print.

This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.