John Goodchild – författare

For four decades Professional Investor and its predecessor, Investment Analyst, the journal of The Institute of Investment Management and Research, has been publishing sound investment advice on topical issues from leading experts in the field. The articles in this collection cover financial subjects ranging from the first introduction computers to mathematical techniques into finance, through the oil crisis years, to the valuation of brands, intellectual property and goodwill. Each article provides a fascinating insight both into the subject concerned and into contemporary thinking at the time of writing. All the articles have been selected for their significance to the financial world today. These fascinating articles are as relevant today as when first written.The Institute of Investment management and Research (IIMR) is the professional Examining body for investment analysts and fund managers in the UK. It provides the 'Threshold Competence' examination for fund managers and analysts, in addition to a six paper Associate examination.The Institute was founded in 1955 as the Society of Investment Analysts and changed its name in 1992. It was a founding member of EFFAS and has close links with AIMR in the US.Professional Investor is the journal of the IIMR and is published ten times a year.

The field of oligonucleotide therapeutics research is ripe with the prospect of new discoveries. In Therapeutic Oligonucleotides: Methods and Protocols, a selection of established and emerging methods for the application of oligonucleotides as therapeutics are presented, all providing the tools needed to inspire great changes in the field. Divided into twenty-one chapters, this detailed volume meticulously describes vital protocols for optimizing and improving cell uptake, such as photochemical internalization, modified cell penetrating peptides, antibody conjugates, and nanoparticles. Other chapters address quantitation of RNA therapeutics in cells, assaying gene knockdown, selecting the best target site and synthesis of various modified oligonucleotides. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Therapeutic Oligonucleotides: Methods and Protocols serves as a timely resource for both professionals and novices pursuing research in this exciting and pioneering field.

The field of oligonucleotide therapeutics research is ripe with the prospect of new discoveries. In Therapeutic Oligonucleotides: Methods and Protocols, a selection of established and emerging methods for the application of oligonucleotides as therapeutics are presented, all providing the tools needed to inspire great changes in the field. Divided into twenty-one chapters, this detailed volume meticulously describes vital protocols for optimizing and improving cell uptake, such as photochemical internalization, modified cell penetrating peptides, antibody conjugates, and nanoparticles. Other chapters address quantitation of RNA therapeutics in cells, assaying gene knockdown, selecting the best target site and synthesis of various modified oligonucleotides. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Therapeutic Oligonucleotides: Methods and Protocols serves as a timely resource for both professionals and novices pursuing research in this exciting and pioneering field.