John Holton – författare

Case Studies in Infectious Disease presents 40 case studies featuring the most important human infectious diseases worldwide. Fully revised and updated in this second edition, the book describes the natural history of infection from point of entry of the pathogen through to clinical management of the resulting disease or condition. A further 8 case studies have been provided online as supplementary material, and these can be downloaded by students. Five core sets of questions are posed in each case, with the answers covering the nature of the infectious agent, route(s) of spread and of infection, pathogenesis of disease, host response to infection, clinical manifestations, diagnosis, treatment and prevention. This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms and diseases, fully integrating microbiology and immunology throughout.KEY FEATURES High-resolution photos accompany each case, from the causative agents of disease to the clinical manifestations of the infection. Exquisite artwork helps to illustrate important concepts throughout the book. Eight new cases added to this new edition, extending coverage of important infectious diseases of worldwide significance. A standardized set of core questions allows students to compare directly differences between microbes such as their structure, clinical manifestations, host response, pathogenesis and availability of vaccines. Questions and answers available online, test the reader’s understanding of each case study.The book provides essential case-based learning for undergraduate and graduate microbiology students, while medical students and trainee physicians will also find the up-to-date information on 48 globally important infectious diseases outlined in a clear, digestible form, invaluable during undergraduate studies and in future clinical practice.

Case Studies in Infectious Disease presents 40 case studies featuring the most important human infectious diseases worldwide. Fully revised and updated in this second edition, the book describes the natural history of infection from point of entry of the pathogen through to clinical management of the resulting disease or condition. A further 8 case studies have been provided online as supplementary material, and these can be downloaded by students. Five core sets of questions are posed in each case, with the answers covering the nature of the infectious agent, route(s) of spread and of infection, pathogenesis of disease, host response to infection, clinical manifestations, diagnosis, treatment and prevention. This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms and diseases, fully integrating microbiology and immunology throughout.KEY FEATURES High-resolution photos accompany each case, from the causative agents of disease to the clinical manifestations of the infection. Exquisite artwork helps to illustrate important concepts throughout the book. Eight new cases added to this new edition, extending coverage of important infectious diseases of worldwide significance. A standardized set of core questions allows students to compare directly differences between microbes such as their structure, clinical manifestations, host response, pathogenesis and availability of vaccines. Questions and answers available online, test the reader’s understanding of each case study.The book provides essential case-based learning for undergraduate and graduate microbiology students, while medical students and trainee physicians will also find the up-to-date information on 48 globally important infectious diseases outlined in a clear, digestible form, invaluable during undergraduate studies and in future clinical practice.

Case Studies in Infection Control has 25 cases, each focusing on an infectious disease, which illustrate the critical aspects of infection control and prevention. Scenarios in the cases are real events from both community and hospital situations, and written by experts. Although brief comments are included in relation to the organism, diagnosis, and treatment the main emphasis is on the case, its epidemiology, and how the situation should be managed from the perspective of infection control and prevention. Each case also has multiple choice questions and answers as well as listing international guidelines and references. All the cases will be an invaluable learning tool for anyone studying or practicing infection control.

What happened to Alexander the Great’s empire when he died, and to the generals and companions that had conquered that empire with him? How did they begin to develop their own power and positions after his death?Alexander’s Successors and the Creation of Hellenistic Kingship reconstructs how the development of royal ideologies led to five powerful new kingships after Alexander’s death. It reveals how ideological performances and ongoing competition among the post-Alexander elite created the reality of the long-lasting institution of Hellenistic kingship, which would last for generations and even centuries as the model for autocratic power in the ancient world. A parallel study, Royal Traditions and the Consolidation of Power by Alexander’s Successors, then examines the innovative new traditions of royal ideology that were developed in the consolidation of the new Hellenistic kingships.Ranging from the early regencies and civil wars after Alexander’s death to the formation of multiple independent kingdoms and beyond, the generation of Alexander’s successors (323-276 BC) is comprehensively investigated. With a comparative perspective and detailed studies of diverse evidence, this is the first dedicated study of the beginnings of Hellenistic kingship and the first to put these beginnings in an international context.

What happened to Alexander the Great’s empire when he died? How did his generals and companions, who had once conquered that empire with him, shape the political landscape after his death? John Holton reconstructs how the development of royal ideologies by Alexander’s Successors led to the emergence of five powerful new kingships across the former Macedonian empire. He demonstrates the creation of Hellenistic kingship as a unified phenomenon and shows how ideas of superior status were articulated in the earliest post-Alexander years, including through monumental display and heroic imagery. He also explores the power of symbolism in the form of the royal diadem and the drama of staged royal accessions, plus the value of concepts like 'spear-won land' in the shared ideological environment of this period.Ranging from the early regencies and civil wars after Alexander’s death to the formation of multiple independent kingdoms and beyond, Holton reveals how the competitive and performative development of royal ideology in the generation of Alexander’s Successors (323–276 BC) created the reality of the long-lasting institution of Hellenistic kingship, which would stand for centuries, as the model for autocratic power in the ancient world. With a comparative perspective and detailed studies of diverse evidence, this is the first dedicated study of the beginnings of Hellenistic kingship at the hands of Alexander’s Successors that puts these beginnings into an international context and draws the main actors into a joint analysis.

In the wake of Alexander the Great's death, his ambitious Successors sought to solidify their positions as kings and establish a framework of new royal traditions. John Holton delves into the interconnected strategies employed by Antigonus, Demetrius, Ptolemy, Seleucus, Lysimachus and Cassander, as well as their heirs, as they consolidated their royal power between 323 and 276 BC. Through a wide-ranging examination of royal ideology and its formative impact, a set of studies explores the significance of discursive power in the new kings’ toolkits, the wide spectrum of god–king relations that were developed to project royal status, the innovative development of father–son joint kingship as a successional mechanism, and the symbolic means for supporting the translation of power to a second generation of kings.Set against the backdrop of a rapidly evolving political landscape in the early Hellenistic world, this volume offers invaluable insights into the transition from Alexander’s single empire to a multipolar world of competing royal dynasties. This period was in turn foundational for the longer-term institution of Hellenistic kingship, which played a pivotal role in in the history of ancient Greece and the near east. By bringing the Successors into a single discussion, with a comparative perspective and detailed studies of diverse evidence, Holton provides a fuller picture of the origins of Hellenistic royal practice.

Examining the period of political consolidation after Alexander the Great’s death, John Holton reconstructs how the successors used new frameworks of royal ideology to create long-term kingships. There is a particular focus on the deeper manoeuvres within the inter-generational impact raging from the influence of religion and family relations, to succession-planning and royal funerals. In this innovative book, Holton expertly reveals how powerful elites either succeeded or failed in creating lasting dynastic power. From the chaos of a collapsing empire to the solidification of a new model for autocratic power, the consolidation of the institution of Hellenistic kingship across the generation of Alexander’s successors (323-276 BC) is comprehensively investigated. With a comparative perspective and detailed studies of diverse evidence, this is the first dedicated study of the consolidation of Hellenistic kingship and the first to put these beginnings in an international context.