John K-J. Li - Böcker

The study of cardiovascular function is vital to contemporary biomedical research. However, integration between cellular and subcellular research and organ-level studies is often lacking, as is integration of clinical and basic investigation. This book examines cardiovascular system function from the perspectives of assessment and analysis, with a focus on evaluating function at different anatomical levels using a combination of analytical, experimental, and clinical measurements.

Comparative Cardiovascular Dynamics of Mammals offers never-before-published data on the structure and function of the circulatory systems of the different mammalian species. This text explores classic allometry, dimensional analysis, and modern hemodynamics to establish similarity principles that provide a necessary and important step in understanding the natural common design and functional features of the cardiovascular systems of different mammals.Fluid and blood vessel mechanics, pulse transmission characteristics, cardiac energetics and mechanics, as well as heart-arterial system interaction are included in this essential reference. The sensitivity of parameters and similarity of principles in the diagnosis of cardiovascular diseases are also addressed. This book also describes the natural processes involved in the functional development of the mammalian cardiovascular system.By using modern methods to present recent findings on the similarities and differences of the mammalian cardiovascular system, the author provides an easily understood approach to this dynamic field of study.

John Li applies powerful new developments in biorheological analysis, experimental validation, and clinical assessment to the fluid dynamics of arterial circulation, laying the foundation for effective experimental and clinical applications. Using quantitative methods extensively, Dr. Li illuminates the physiology and rheology of arteries, the fundamental theories and modeling of the arterial system, blood pressure and flow and their transmission in arteries, and the coupling and interaction of the arterial system and the heart. On the clinical level he examines the alteration of structure and function of arteries in such disease conditions as hypertension, myocardial ischemia, arterial and aortic valve stenoses, and aging. Innovative in its quantitative analysis, computer modeling, and practical clinical applications, The Arterial Circulation: Physical Principles and Clinical Applications will immediately become the standard reference in the field for all those investigating the structure and function of arteries, and how arterial circulation can be accurately and quantitatively assessed in clinical situations.

The objective of this book is to provide the researcher and clinician with the recent developments in the analysis and assessment of cardiovascular func­ tion. This book integrates the micro-level and organ-level function so that new infor­ mation may be assimilated into the cardiovascular system as a whole.

John Li applies powerful new developments in biorheological analysis, experimental validation, and clinical assessment to the fluid dynamics of arterial circulation, laying the foundation for effective experimental and clinical applications. Using quantitative methods extensively, Dr. Li illuminates the physiology and rheology of arteries, the fundamental theories and modeling of the arterial system, blood pressure and flow and their transmission in arteries, and the coupling and interaction of the arterial system and the heart. On the clinical level he examines the alteration of structure and function of arteries in such disease conditions as hypertension, myocardial ischemia, arterial and aortic valve stenoses, and aging. Innovative in its quantitative analysis, computer modeling, and practical clinical applications, The Arterial Circulation: Physical Principles and Clinical Applications will immediately become the standard reference in the field for all those investigating the structure and function of arteries, and how arterial circulation can be accurately and quantitatively assessed in clinical situations.

Recent advances in vascular biology and vascular engineering have led to the understanding and integration of the two fields. A feature that is fundamental to both is the dynamic aspects of the vascular system. Although the basic principles governing blood flow and the circulatory function are known, new approaches to examining the interaction of different parts of the vascular system have emerged. These include measurement techniques and quantitative methods with greater use of modern technology and computer modeling. An obvious need therefore exists for a book that deals specifically with the dynamics of the vascular system.This book begins with the historical discoveries of the features of the vascular system and its importance in the overall circulatory function. Modern aspects of vascular biology in terms of structure and function are then described, followed by the introduction of physical principles and basic fluid mechanics for quantitative analysis. The hemodynamics of large arteries, the optimal structure of vascular branching and the pulsatile energy transmission and modeling aspects are elaborated. These are extended to analyze the function of the venous system and the microcirculation. Finally, the integrated vascular system and its response and adaptation to diseased conditions, such as aging, stenosis, hypertension, myocardial ischemia, atheroslerosis and stroke are explained. The overall emphasis is on the dynamic nature of the vascular system.

The first edition of the book was written employing mathematical techniques to formulate the physical principles involved in the structural and functional correlates of the underlying physiology.This current and self-contained second edition updates many of the new findings since its first edition a decade ago. It also includes a new chapter on the "Interaction with the Heart". The dynamics of the arterial system, the venous system, the microcirculation and their interaction with the heart are quantitatively described in terms of their structures and functions. Clinical measurements, applications to the cardiovascular field and physiological mechanisms are clearly identified throughout the text. Most importantly, worked examples are provided, such that the readers can appreciate the application aspects of the underlying formulation.