John S. Axford – författare

This book contains the Proceedings of the Sixth Jenner Glycobiology and Medicine Symposium, held 14-17 September, 2002, in Seillac, France. This book highlights the latest developments in glycoimmunology, including glycosylation-dependent bacterial and viral infections, lectin and proteoglycan-dependent interactions in leukocyte homing processes to lymphoid tissues and inflamed tissues, congenital defects in glycosylation of glycoproteins and glycolipids, and the role of carbohydrates in tumour development and neuropathology, including Creutzfeldt-Jakob disease.

7th Jenner Glycobiology and Medicine Symposium Sunday5-W Wednesday 8 September 2004 John S. Axford StGeorge's, University of London, UK The potential for glycobiology to improve the practice of medicine has been well recognised, which is why biannual meetings concerning the association have been taking place for the last 14 years. The science of glycobiology has matured rapidly, and with it the far reaching clinical implications are becoming understood. The next decade is going to see this ?nal frontier of science conquered. The impact this understanding of glycobiology will have upon our practice of medicine is going to be exciting. The 7th Jenner Glycobiology and Medicine Symposium was designed tore?ecttheseadvances.Allthemajorclinicalareaswereinvolved,withcontributions from pivotal players in science and medicine. As with our previous meetings, junior scientists were involved as we recognise that at the end of the next decade they will be in the driving seat. This introduction serves as a taster to whet your appetite. From embryogenesis to pathogenesis, glycosylation plays a pivotal role.Complex and hybrid N-glyans and O-fucose glycans are critical in oocyte devel- ment and function. This area must surely be a fertile ground for glycosylation research.

Over the past decade significant advances in technology have opened up the field of glycobiology. In particular, improved methods for carbohydrate analysis have led to important biochemical observations demonstrating that sugars play crucial roles in human physiology. It is clear that many diseases are associated with characteristic changes in glycosylation and furthermore, the possibility of modulating glycan processing to treat disease is beginning to be realised. This volume summarises some of the important recent developments in "glycobiology and medicine. " We highlighted some of the numerous areas in which there are glycosylation dependant pathological mechanisms causing common diseases. The next decade will undoubtedly see novel diagnostic and therapeutic techniques originating from these observations. This will significantly enhance our ability to combat infection and diseases such as bacterial and viral infections, some cancers, glycolipid storage disorders, systemic autoimmune disease and disorders that involve cytokine related inflammatory mechanisms. These topics were discussed at the 6th Jenner Glycobiology and Medicine meeting.This meeting received a European Commission Education grant (No. HPCF-2002-00250). CONTENTS Glycosylation Dependent Bacterial Infections 1. A Sweet Coating-How Bacteria Deal with Sugars ...3 Anthony P. Corfield, Rebecca Wiggins, Cathryn Edwards, Neil Myerscough, Bryan F. Warren, Peter Soothill, Michael R. Millar, and Patrick Horner 2. The Glycosylation of Airway Mucins in Cystic Fibrosis and Its Relationship with Lung Infection by Pseudomonas aeruginosa ...17 . Philippe Roussel and Genevieve Lamblin 3. Structural Basis for Bacterial Adhesion in the Urinary Tract...33 . . Jenny Berglund and Stefan D.

Glycoimmunology, the studyofthe oligosaccharide components ofglycoconjugates as an integral component ofthe immune system, has opened up a rapidly evolving field. It draws from a broad spectrum of technologies, ranging from classical synthetic organic chemistry, to molecular biology and beyond. The structural microheterogenity ofoligosac- charides found on glycoproteins and glycolipids is immense and reflects the enormous inherent structural diversity of these carbohydrate side chains and their ability to encode information. In this respect glycoimmunology represents an exciting and significant oppor- tunity for both biotechnology and pharmaceutical research. This book summarizes the proceedings of the Third Jenner International Glycoim- munology meeting, held at IL Ciocco Tuscany in October 1994, which was co-ordinated underthe auspicesofEUROCARB, the EuropeanCommunityConcertedAction forArthritis and Carbohydrate Research. This meeting brought together leading academic and commer- cial researchers at the forefront ofglycosylation and immunology, with the aimofreviewing and focusing on applied and basic research relating to glycoimmunology and its clinical implications.

Lyme Borreliosis is a worldwide infectious disease causing a multisystem illness with considerable morbidity, particularly in North America and Europe. The causative agent is the spirochaete Borrelia burgdorferi, which is usually transmitted by the ixodid tick from animal reservoirs. This book is formed by contributions from the Second European Symposium on Lyme Borreliosis, held at St George's Hospital Medical School, London in 1993, which reviewed the current state of knowledge of the condition with regard to clinical manifestations, diagnosis, treatment, ecology, epidemiology, biology and immunopathogenesis. In this book, important data is reviewed concerning the clinical manifestations of Lyme Borreliosis. It seems that strain variation of the spirochaete is the main cause of regional differences seen in the clinical presentation of patients. One striking example of this, is the relatively high incidence of Lyme arthritis in the USA and apparent rarity of this manifestion in some areas of Europe. These important studies open the way for exciting new research that focuses on the immunological and molecular mechanisms that result in disease. A full insight into the ecology of Borrelia burgdorferi is essential to a balanced understanding of the disease and a number of excellent reviews on this subject are included. Significant advances with regard to the biology of Borrelia burgdorjeri and the immunopathogenic mechanisms that result in disease have been made, enabling the role of the Band T lymphocytes in disease to be established and the development of sophisticated phenotyping methods, improved diagnostic tests and effective vaccines.

The Jenner International Glycoimmunology Meetings have charted the rapid devel­ opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti­ inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re­ cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco­ immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu­ nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for the 5th.

Lyme Borreliosis is a worldwide infectious disease causing a multisystem illness with considerable morbidity, particularly in North America and Europe. The causative agent is the spirochaete Borrelia burgdorferi, which is usually transmitted by the ixodid tick from animal reservoirs. This book is formed by contributions from the Second European Symposium on Lyme Borreliosis, held at St George''s Hospital Medical School, London in 1993, which reviewed the current state of knowledge of the condition with regard to clinical manifestations, diagnosis, treatment, ecology, epidemiology, biology and immunopathogenesis. In this book, important data is reviewed concerning the clinical manifestations of Lyme Borreliosis. It seems that strain variation of the spirochaete is the main cause of regional differences seen in the clinical presentation of patients. One striking example of this, is the relatively high incidence of Lyme arthritis in the USA and apparent rarity of this manifestion in some areas of Europe. These important studies open the way for exciting new research that focuses on the immunological and molecular mechanisms that result in disease. A full insight into the ecology of Borrelia burgdorferi is essential to a balanced understanding of the disease and a number of excellent reviews on this subject are included. Significant advances with regard to the biology of Borrelia burgdorjeri and the immunopathogenic mechanisms that result in disease have been made, enabling the role of the Band T lymphocytes in disease to be established and the development of sophisticated phenotyping methods, improved diagnostic tests and effective vaccines.

The Jenner International Glycoimmunology Meetings have charted the rapid devel­ opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti­ inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re­ cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco­ immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu­ nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for the 5th.