Jon Palfreman – författare

'An excellent grasp on the science...but it is as a human story that the book is most compelling...' TLSSeven million people worldwide suffer from Parkinson's, with more men having the disease than women. Yet it remains an enigma, with doctors, researchers and patients hunting for a cure. In Brain Storms the award-winning journalist and veteran TV producer, Jon Palfreman, tells their stories, stories that take on a particular urgency since he himself has been diagnosed with the illness.Palfreman chronicles how scientists have laboured to crack the mystery of what was once called the 'shaking palsy', from the earliest clinical descriptions to the cutting edge of molecular neuroscience. He charts the victories and setbacks of a massive international effort to get the better of the disease, referred to as one of the best windows into the brain itself.Brain Storms is also a profoundly personal investigation into Palfreman's own struggles and those of others living with Parkinson's. The race is on to stop or reverse conditions like Parkinson's and Alzheimer's. Brain Storms is the long-overdue, riveting detective story of that race, and a passionate, insightful account of the lives of those affected.

In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale… It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down… it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks