Jorge Quiroz – författare

This book examines statistical techniques that are critically important to Chemistry, Manufacturing, and Control (CMC) activities. Statistical methods are presented with a focus on applications unique to the CMC in the pharmaceutical industry.  The target audience consists of statisticians and other scientists who are responsible for performing statistical analyses within a CMC environment. Basic statistical concepts are addressed in Chapter 2 followed by applications to specific topics related to development and manufacturing. The mathematical level assumes an elementary understanding of statistical methods.  The ability to use Excel or statistical packages such as Minitab, JMP, SAS, or R will provide more value to the reader.The motivation for this book came from an American Association of Pharmaceutical Scientists (AAPS) short course on statistical methods applied to CMC applications presented by four of the authors.  One of the course participants asked us for a good reference book, and the only book recommended was written over 20 years ago by Chow and Liu (1995).  We agreed that a more recent book would serve a need in our industry.  Since we began this project, an edited book has been published on the same topic by Zhang (2016).  The chapters in Zhang discuss statistical methods for CMC as well as drug discovery and nonclinical development.  We believe our book complements Zhang by providing more detailed statistical analyses and examples.

This book examines statistical techniques that are critically important to Chemistry, Manufacturing, and Control (CMC) activities. Statistical methods are presented with a focus on applications unique to the CMC in the pharmaceutical industry.  The target audience consists of statisticians and other scientists who are responsible for performing statistical analyses within a CMC environment. Basic statistical concepts are addressed in Chapter 2 followed by applications to specific topics related to development and manufacturing. The mathematical level assumes an elementary understanding of statistical methods.  The ability to use Excel or statistical packages such as Minitab, JMP, SAS, or R will provide more value to the reader.The motivation for this book came from an American Association of Pharmaceutical Scientists (AAPS) short course on statistical methods applied to CMC applications presented by four of the authors.  One of the course participants asked us for a good reference book, and the only book recommended was written over 20 years ago by Chow and Liu (1995).  We agreed that a more recent book would serve a need in our industry.  Since we began this project, an edited book has been published on the same topic by Zhang (2016).  The chapters in Zhang discuss statistical methods for CMC as well as drug discovery and nonclinical development.  We believe our book complements Zhang by providing more detailed statistical analyses and examples.

La ciencia indica que la única forma de contener el cambio climático es alcanzando la carbono neutralidad global antes del año 2050. Para ello, Chile desarrolló un plan concreto y ambicioso, cuyas etapas iniciales se están comenzando a cumplir. Este riguroso estudio de los economistas Felipe Givovich, Jorge Quiroz y Klaus Schmidt-Hebbel viene a complementar la estrategia del país, analizando en particular el rol que puede cumplir el gas natural en la transición energética hacia la carbono neutralidad de Chile. La principal conclusión del libro es que el uso más intensivo de gas en los sectores eléctrico, industrial y transporte permite cumplir un 73% de la reducción de emisiones de gases de efecto invernadero que Chile ha comprometido en el marco del Acuerdo de Paris para el año 2030. Esta sustitución no tiene asociada un costo fiscal."Las empresas de gas natural tienen la oportunidad única de estar a la vanguardia del desarrollo carbono neutral del país, y no tengo dudas que este libro de Felipe Givovich, Jorge Quiroz y Klaus Schmidt-Hebbel es un gran aporte para avanzar en esa dirección". Juan Carlos Jobet, biministro de Energía y Minería."El estudio realizado por Felipe Givovich, Jorge Quiroz y Klaus Schmidt-Hebbel, cuyos resultados se presentan en este libro, es particularmente oportuno. Los autores identifican y evalúan rutas concretas de acción sobre la base de un riguroso análisis económico, opinión técnica y revisión de casos".Carlos Cortés Simon, presidente ejecutivo.Gustavo Schettini, presidente del directorio.Asociación de Gas Natural.